Opportunity Information: Apply for PAR 15 285
Apply for PAR 15 285
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Bioengineering Research Partnership (BRP) Non or Minimally Invasive Methods to Measure Biochemical Substances during Neonatal and Perinatal Patient Care and Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jun 22, 2015 and posted on Jun 22, 2015.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education Public and State controlled institutions of higher education State governments Independent school districts Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Bioengineering Research Partnership (BRP) funding opportunity PAR-15-285 is an NIH R01 grant competition focused on advancing non- or minimally invasive ways to measure biochemical substances during neonatal and perinatal care and research. The core idea is to bring bioengineering and biomedical scientists together to create practical measurement technologies that reduce risk, discomfort, and blood loss in very small or medically fragile patients while still delivering clinically useful information. The announcement emphasizes approaches that can be used in real-world perinatal settings, where rapid decision-making, small sample volumes, and safe monitoring are especially important. It also explicitly encourages "lab-on-a-chip" style platforms aimed at rapid diagnostic or prognostic readouts, reflecting a strong interest in point-of-care or near-patient testing that can meaningfully support clinical care and research workflows.
This opportunity sits within NIH's broader mission areas related to child health and human development (CFDA 93.865: Child Health and Human Development Extramural Research), and it is categorized under health-related assistance. The funding instrument is a grant, specifically an R01, which generally supports substantial, hypothesis-driven or technology-development research projects that are mature enough to propose a clear plan, defined aims, and measurable milestones. The FOA is discretionary, does not require cost sharing or matching, and was originally posted June 22, 2015, with an application window that closed January 7, 2018 (archived February 7, 2018). Even though the specific FOA is archived, the description captures a continuing NIH priority area: better, safer measurement tools for neonatal and perinatal patient management and research.
In terms of who can apply, the eligibility list is broad and includes many types of U.S. organizations as well as certain non-U.S. entities. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government (state, county, city/township), as well as independent school districts and public housing authorities/Indian housing authorities. The FOA also clarifies additional eligible groups such as federally recognized and other tribal governments and organizations, historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based and community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign (non-U.S.) organizations. The breadth of eligibility aligns with the partnership concept and the reality that impactful neonatal/perinatal measurement technology often comes from cross-sector teams spanning engineering, clinical care, and product development.
The practical scope implied by the FOA is the development of methods and devices that can detect or quantify biochemical substances with minimal invasiveness, which can include strategies that avoid venipuncture, reduce blood draw volume, use alternative biofluids, or rely on surface/near-surface sensing approaches. The emphasis on rapid diagnostic or prognostic "lab-on-a-chip" methods signals interest in miniaturized, integrated systems that can process tiny samples quickly, potentially at the bedside, and deliver actionable results. In neonatal and perinatal contexts, these solutions are especially valuable because standard sampling can be challenging due to limited blood volume, high vulnerability to iatrogenic anemia, and the need to avoid adding stress or infection risk. A successful project under this FOA would therefore be expected to balance innovative bioengineering with a clear pathway toward clinical relevance, usability in care settings, and measurement performance appropriate for neonatal/perinatal decision-making.
For applicants seeking the original full announcement text and any detailed instructions that were active at the time, NIH provided an official link to the FOA on the NIH grants guide (http://grants.nih.gov/grants/guide/pa-files/PAR-15-285.html). Administrative questions about accessing or linking to the announcement were directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Bioengineering Research Partnership (BRP) PAR-15-285 (NIH R01) - FAQs
1) What is PAR-15-285 (Bioengineering Research Partnership, BRP)?
PAR-15-285 is an NIH Bioengineering Research Partnership (BRP) funding opportunity that used the R01 grant mechanism to support research focused on advancing non- or minimally invasive ways to measure biochemical substances during neonatal and perinatal care and research.
2) What is the main goal of this funding opportunity?
The central goal is to bring bioengineering and biomedical scientists together to create practical measurement technologies that reduce risk, discomfort, and blood loss in very small or medically fragile neonatal/perinatal patients while still providing clinically useful information.
3) What types of projects does the FOA emphasize?
The FOA emphasizes approaches that can work in real-world perinatal settings, where rapid decision-making, small sample volumes, and safe monitoring are critical. It highlights technology that can be used in clinical workflows and research environments supporting neonatal and perinatal patient management.
4) What does "non- or minimally invasive measurement of biochemical substances" mean in this context?
It refers to methods and devices designed to detect or quantify biochemical substances while avoiding or reducing invasive sampling. Examples described by the scope include strategies that avoid venipuncture, reduce blood draw volume, use alternative biofluids, or rely on surface/near-surface sensing approaches.
5) Why is the neonatal/perinatal setting specifically highlighted?
Neonatal and perinatal patients can be especially vulnerable to blood loss and complications from standard sampling. The FOA notes the importance of minimizing iatrogenic anemia risk, reducing stress and discomfort, and limiting infection risk, while still enabling timely clinical decisions and effective monitoring.
6) Does the FOA encourage point-of-care or near-patient testing approaches?
Yes. The announcement explicitly encourages "lab-on-a-chip" style platforms aimed at rapid diagnostic or prognostic readouts, signaling strong interest in miniaturized systems that can deliver actionable results quickly, potentially at or near the bedside.
7) What is meant by "lab-on-a-chip" in the context of this opportunity?
Within the description provided, "lab-on-a-chip" refers to miniaturized, integrated platforms that can process very small samples rapidly and return diagnostic or prognostic information suitable for neonatal/perinatal decision-making and research workflows.
8) What funding mechanism does this opportunity use?
The funding instrument is a grant using the NIH R01 mechanism, which generally supports substantial research projects that are mature enough to present a clear plan, defined aims, and measurable milestones.
9) Is cost sharing or matching required?
No. The FOA is described as discretionary and does not require cost sharing or matching.
10) What NIH mission area or assistance listing is this associated with?
The opportunity sits within NIH mission areas related to child health and human development and is associated with CFDA 93.865: Child Health and Human Development Extramural Research. It is categorized under health-related assistance.
11) Is this FOA still open?
No. The application window closed on January 7, 2018, and the FOA was archived on February 7, 2018.
12) If the FOA is archived, why might it still be relevant?
Even though this specific FOA is archived, the description reflects a continuing NIH priority area: developing better, safer measurement tools for neonatal and perinatal patient management and research, particularly those that reduce invasiveness while remaining clinically useful.
13) Who was eligible to apply?
Eligibility was broad and included many U.S. organization types as well as certain non-U.S. entities. Eligible applicants included:
- Public and private institutions of higher education
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (including small businesses and other for-profit entities)
- State, county, and city/township governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Federally recognized tribal governments and other tribal governments
- Tribal organizations
- Historically Black colleges and universities (HBCUs)
- Hispanic-serving institutions
- Tribally controlled colleges and universities (TCCUs)
- Alaska Native and Native Hawaiian serving institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Faith-based and community-based organizations
- U.S. territories or possessions
- Regional organizations
- Eligible federal agencies
- Foreign (non-U.S.) organizations
14) Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA states that foreign (non-U.S.) organizations are included among eligible applicants.
15) Are small businesses or for-profit organizations allowed to apply?
Yes. For-profit organizations, including small businesses and other for-profit entities, are listed as eligible.
16) Does the FOA encourage partnerships or cross-sector teams?
Yes. The core concept is to bring bioengineering and biomedical scientists together, reflecting the partnership model and the cross-disciplinary nature of neonatal/perinatal measurement technology development.
17) What kinds of practical constraints should proposed technologies consider?
The FOA description highlights constraints common in perinatal settings: rapid decision-making needs, extremely small sample volumes, and the importance of safe, low-risk monitoring. Technologies are expected to be realistic for clinical settings and useful for care and research workflows.
18) What outcomes would a "successful" project be expected to balance?
Based on the description, a successful project would balance innovative bioengineering with a clear path toward clinical relevance, usability in care settings, and measurement performance appropriate for neonatal/perinatal decision-making.
19) Where can the original FOA text be found?
The original announcement was available on the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-15-285.html
20) Who was the listed contact for administrative questions about accessing or linking to the announcement?
Administrative questions about accessing or linking to the announcement were directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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