Opportunity Information: Apply for RFA ES 13 010

  • The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Biogeochemical Interactions Affecting Bioavailability for in situ Remediation of Hazardous Substances (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.143 NIEHS Superfund Hazardous SubstancesBasic Research and Education.
  • This funding opportunity was created on Jul 24, 2013 and posted on Jul 24, 2013.
  • Applicants must submit their applications by Nov 1, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $150,000.00 in funding.
  • Eligible applicants include: Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The grant opportunity titled "Biogeochemical Interactions Affecting Bioavailability for in situ Remediation of Hazardous Substances (R01)" (Funding Opportunity Number RFA-ES-13-010) was issued by the National Institutes of Health through the NIEHS Superfund Hazardous Substances Basic Research and Education program (CFDA 93.143). It focuses on the reality that contaminants in soil, sediment, surface water, and groundwater do not behave in simple or predictable ways once released into the environment. Instead, they are continually influenced by intertwined biological, geological, and chemical processes. Those processes can change how contaminants move, how long they persist, how toxic they are, and most importantly, how available they are for uptake by people and ecological receptors. Because in situ remediation strategies treat contamination in place rather than excavating or removing it, the success of these approaches depends heavily on understanding these site-specific biogeochemical interactions.

The purpose of the FOA is to fund problem-solving research that digs into mechanisms: how the combination of microbes, mineral surfaces, redox conditions, organic matter, pH, nutrients, and other environmental factors can increase or decrease contaminant bioavailability during or after in situ remediation. The goal is not just to generate descriptive observations, but to produce mechanistic insights that can be used to optimize remediation performance and reduce exposure risk. In practical terms, the research supported under this announcement is meant to strengthen science-based decisions for site management, including how remedies are selected, how priorities are set across contaminated sites, and how to evaluate whether an in situ approach is truly reducing risk rather than simply transforming contaminants into different forms.

This is an R01 grant mechanism, meaning it is intended to support a defined research project with a clear set of aims and an emphasis on rigorous study design. The overall funding estimated for the announcement is $1,500,000, with an award ceiling of $150,000, and there is no cost sharing or matching requirement. The opportunity was posted and created on July 24, 2013, with an original and final application closing date of November 1, 2013, and it was archived on December 2, 2013. While the dates indicate it is a historical solicitation, the scope and framing are still useful as a reference point for the kinds of research questions NIEHS has considered high priority at the intersection of remediation science and exposure reduction.

Eligibility is oriented toward U.S.-based academic and related institutions. Public and state-controlled institutions of higher education and private institutions of higher education are eligible, along with a range of designated institution types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). Foreign institutions are not eligible, and foreign components of U.S. organizations are not allowed under this FOA.

The announcement underscores that understanding bioavailability in the context of in situ remediation is central to improving outcomes. Bioavailability is a bridge between contamination and actual risk, because it reflects what fraction of a chemical is accessible for biological uptake and harm, not merely what is present analytically in a sample. By funding mechanistic research on biogeochemical interactions, NIEHS aimed to support advances that could make in situ remedies more predictable, more effective, and better aligned with real-world risk reduction at hazardous waste sites. For full details, the FOA points applicants to the NIH guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-13-010.html and provides NIH Office of Extramural Research webmaster contacts for access or linking issues.

Frequently Asked Questions (FAQs)

What is the official title of this grant opportunity?

The opportunity is titled "Biogeochemical Interactions Affecting Bioavailability for in situ Remediation of Hazardous Substances (R01)."

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is RFA-ES-13-010.

Which federal agency and program issued this FOA?

This FOA was issued by the National Institutes of Health (NIH), through the National Institute of Environmental Health Sciences (NIEHS) Superfund Hazardous Substances Basic Research and Education program.

What is the CFDA number associated with this program?

The CFDA number listed for this opportunity is 93.143.

What is the main purpose of this FOA?

The purpose is to fund problem-solving, mechanistic research on how biogeochemical interactions affect contaminant bioavailability during or after in situ remediation of hazardous substances. The emphasis is on understanding mechanisms that can be used to optimize remediation performance and reduce exposure risk.

What kinds of environments or media does the FOA focus on?

The FOA highlights contaminants in soil, sediment, surface water, and groundwater, and how their behavior changes once they are released into the environment.

Why does this FOA emphasize biogeochemical interactions?

Because contaminants do not behave in simple or predictable ways in real environmental settings. Intertwined biological, geological, and chemical processes can alter contaminant movement, persistence, toxicity, and especially bioavailability, which is central to actual exposure and risk.

What is meant by "in situ remediation" in this FOA?

In situ remediation refers to strategies that treat contamination in place rather than excavating or removing contaminated materials. The FOA stresses that the success of in situ remedies depends heavily on site-specific biogeochemical conditions.

What does the FOA mean by "bioavailability," and why is it important?

Bioavailability is described as the bridge between contamination and actual risk. It refers to the fraction of a chemical that is accessible for uptake by people or ecological receptors and therefore capable of causing harm, as opposed to merely being detectable in an analytical sample.

What types of scientific factors does the FOA call out as influencing bioavailability?

The FOA specifically mentions the combination of microbes, mineral surfaces, redox conditions, organic matter, pH, nutrients, and other environmental factors as drivers that can increase or decrease contaminant bioavailability.

Is the FOA focused on descriptive studies or mechanistic studies?

The FOA prioritizes mechanistic insights rather than purely descriptive observations. The aim is to explain how and why biogeochemical conditions change bioavailability in ways that matter for remediation performance and exposure reduction.

How is the research expected to be used in practice?

According to the FOA, the research is intended to strengthen science-based decisions for hazardous site management, including selecting remedies, setting priorities across contaminated sites, and evaluating whether an in situ approach is actually reducing risk rather than simply transforming contaminants into different forms.

What grant mechanism does this FOA use?

This is an R01 funding mechanism, intended to support a defined research project with clear aims and an emphasis on rigorous study design.

What is the estimated total funding available under this announcement?

The estimated overall funding described for the announcement is $1,500,000.

What is the award ceiling for individual awards under this FOA?

The award ceiling is $150,000.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

When was the opportunity posted and created?

The FOA was posted and created on July 24, 2013.

What were the application due dates?

The original and final application closing date listed is November 1, 2013.

Is this FOA currently open for applications?

No. The FOA was archived on December 2, 2013, and the listed due dates are in 2013, indicating this is a historical solicitation.

Even if archived, what is the value of this FOA today?

The description notes that while the dates indicate it is historical, the scope and framing are still useful as a reference for the types of research questions NIEHS has considered high priority at the intersection of remediation science and exposure reduction.

Who is eligible to apply?

Eligibility is oriented toward U.S.-based academic and related institutions. Eligible entities include public and state-controlled institutions of higher education and private institutions of higher education.

Are minority-serving institutions included in the eligibility list?

Yes. The FOA lists several designated institution types as eligible, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other similar categories referenced in the announcement.

Are foreign institutions eligible to apply?

No. Foreign institutions are not eligible under this FOA.

Are foreign components of U.S. organizations allowed?

No. The FOA states that foreign components of U.S. organizations are not allowed.

Where can applicants find the full FOA text?

The FOA directs readers to the NIH Guide page: http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-13-010.html.

Who is listed for help with access or linking issues?

The FOA mentions NIH Office of Extramural Research webmaster contacts for access or linking issues.

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