Opportunity Information: Apply for RFA DE 16 004
Apply for RFA DE 16 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biological and Physiological Effects of E cigarette Aerosol Mixtures (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Mar 5, 2015 and posted on Mar 5, 2015.
- Applicants must submit their applications by Jul 28, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts State governments City or township governments Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Biological and Physiological Effects of E cigarette Aerosol Mixtures (R01)" (Funding Opportunity Number RFA-DE-16-004) is a National Institutes of Health discretionary research grant designed to build a clearer scientific understanding of how electronic cigarette (e-cigarette) aerosols affect oral health. The central focus is on the biological and physiological impact of the complex aerosol mixtures generated by e-cigarettes when they come into contact with cells, tissues, and organs in the mouth. In practical terms, the FOA is looking to fund studies that examine how these inhaled and locally deposited aerosols influence the oral and periodontal epithelium, the gingiva, salivary glands, and even tooth-related tissues. A second major emphasis is the oral microbiome, with support for research that can explain how e-cigarette use may shift microbial communities in the mouth and what those shifts might mean for disease risk or oral system function.
The overarching goal is to produce foundational, evidence-based data that can inform health policy decisions. Because e-cigarettes can generate aerosols that vary widely depending on device design, heating conditions, and liquid composition, the FOA highlights the need to understand the effects of real-world aerosol mixtures rather than isolated single chemicals alone. The expectation is that results from projects funded under this announcement would help clarify mechanisms of harm or biological change, identify sensitive targets within oral tissues, and contribute to a stronger scientific basis for evaluating potential risks associated with e-cigarette exposure as it relates to oral and periodontal health.
This opportunity uses the NIH R01 grant mechanism, meaning it is intended for hypothesis-driven, investigator-initiated research projects of a scope and duration typical for R01 awards. The program sits within the NIH health research category and aligns with CFDA 93.121, Oral Diseases and Disorders Research. The total estimated funding listed for the announcement is $3,000,000, with an award ceiling of $250,000. No cost sharing or matching is required, which generally means applicants are not expected to contribute non-federal funds as a condition of the award.
Eligibility is broad and includes a wide range of organizational types. Eligible applicants include public and private institutions of higher education, public and state-controlled universities, private universities, nonprofit organizations (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), for-profit organizations (other than small businesses) as well as small businesses, and multiple levels of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities or Indian housing authorities. The eligibility language also explicitly includes a number of mission- and population-focused institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs). In addition, the FOA indicates eligibility for certain non-U.S. entities (foreign organizations), U.S. territories or possessions, regional organizations, eligible federal agencies, and faith-based or community-based organizations, along with tribal organizations and tribal governments in several categories.
Key dates included in the listing show it was posted and created on March 5, 2015, with an original and current closing date of July 28, 2015, and an archive date of August 28, 2015. The sponsoring agency is the National Institutes of Health, and the full announcement was made available through the NIH grants guide at the provided link. For technical access issues related to the electronic announcement, the contact point listed is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
1) What is the title of this grant opportunity?
The opportunity is titled "Biological and Physiological Effects of E-cigarette Aerosol Mixtures (R01)."
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DE-16-004.
3) Which federal agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
4) What type of grant mechanism does this opportunity use?
This opportunity uses the NIH R01 grant mechanism, which is intended for hypothesis-driven, investigator-initiated research projects of a scope and duration typical for R01 awards.
5) What is the main purpose of this FOA?
The central purpose is to build a clearer scientific understanding of how electronic cigarette (e-cigarette) aerosol mixtures affect oral health, focusing on biological and physiological impacts when these aerosols contact cells, tissues, and organs in the mouth.
6) What research areas or outcomes is the FOA trying to support?
The FOA seeks foundational, evidence-based data that can help clarify mechanisms of harm or biological change, identify sensitive targets within oral tissues, and strengthen the scientific basis for evaluating potential risks of e-cigarette exposure related to oral and periodontal health.
7) Why does the FOA emphasize "aerosol mixtures" instead of single chemicals?
Because e-cigarettes can produce aerosols that vary widely based on device design, heating conditions, and liquid composition, the FOA highlights the need to understand the effects of real-world aerosol mixtures rather than isolated single chemicals alone.
8) What oral tissues and systems are specifically mentioned as areas of interest?
The FOA specifically highlights the oral and periodontal epithelium, gingiva, salivary glands, and tooth-related tissues as relevant targets for study when evaluating the impact of inhaled and locally deposited e-cigarette aerosols.
9) Is the oral microbiome included in the scope of this funding opportunity?
Yes. A second major emphasis is the oral microbiome, including research that examines how e-cigarette use may shift microbial communities in the mouth and what those shifts might mean for disease risk or oral system function.
10) What is the broader goal of funding this research?
The FOA states an overarching goal of producing foundational evidence that can inform health policy decisions related to e-cigarette exposure and oral/periodontal health risks.
11) What is the CFDA number and program area associated with this FOA?
The FOA aligns with CFDA 93.121, Oral Diseases and Disorders Research.
12) What is the total estimated funding amount for the announcement?
The total estimated funding listed for the announcement is $3,000,000.
13) What is the award ceiling listed for this opportunity?
The award ceiling is $250,000.
14) Is cost sharing or matching required?
No. The listing states that no cost sharing or matching is required, meaning applicants are generally not expected to contribute non-federal funds as a condition of the award.
15) Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education (including public/state-controlled and private universities), nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government entities (state, county, city or township, special districts, independent school districts, and public housing authorities or Indian housing authorities).
16) Are mission- or population-focused institutions explicitly included as eligible applicants?
Yes. The eligibility language explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs).
17) Are tribal entities eligible to apply?
Yes. The eligibility language includes tribal organizations and tribal governments in several categories.
18) Are faith-based or community-based organizations eligible?
Yes. The FOA indicates eligibility for faith-based or community-based organizations.
19) Are non-U.S. entities allowed to apply?
Yes. The FOA indicates eligibility for certain non-U.S. entities (foreign organizations), as well as U.S. territories or possessions and regional organizations.
20) Are federal agencies eligible to apply?
Yes. The eligibility language includes eligible federal agencies.
21) When was this opportunity posted and created?
It was posted and created on March 5, 2015.
22) What is the closing date for this opportunity?
The original and current closing date listed is July 28, 2015.
23) Has this funding opportunity been archived?
Yes. The archive date listed is August 28, 2015.
24) Where was the full announcement made available?
The full announcement was made available through the NIH grants guide at the link referenced in the listing.
25) Who should be contacted for technical access issues related to the electronic announcement?
For technical access issues related to the electronic announcement, the listed contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
26) What kind of studies does this FOA appear to prioritize based on its description?
Based on the description, the FOA prioritizes studies that examine biological and physiological effects of e-cigarette aerosol mixtures on oral tissues (including periodontal structures and salivary glands) and studies investigating changes to the oral microbiome and the implications of those changes for oral disease risk or oral system function.
27) What exposure characteristics does the FOA highlight as important for study design?
The FOA highlights that aerosol composition can vary by device design, heating conditions, and liquid composition, and emphasizes understanding effects of real-world aerosol mixtures rather than only single, isolated constituents.
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