Opportunity Information: Apply for RFA DE 16 005
Apply for RFA DE 16 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biological and Physiological Effects of E cigarette Aerosol Mixtures (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Mar 5, 2015 and posted on Mar 5, 2015.
- Applicants must submit their applications by Jul 28, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Special district governments Independent school districts Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education County governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses For profit organizations other than small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Biological and Physiological Effects of E-cigarette Aerosol Mixtures (R21)" (Funding Opportunity Number RFA-DE-16-005) was a discretionary NIH research grant designed to fund early-stage, exploratory studies on how electronic cigarette (e-cigarette) aerosols affect the mouth and surrounding oral tissues. The core aim was to build foundational, evidence-based scientific knowledge about the biological and physiological impacts of e-cigarette aerosol mixtures, with a specific emphasis on oral health. By focusing on mechanisms and measurable effects in oral systems, the program sought to generate data that could ultimately inform public health guidance and health policy decisions related to e-cigarette use.
Scientifically, the FOA emphasized research on the effects of e-cigarette aerosol mixtures on cells, tissues, and organs within the oral cavity. It specifically called out oral and periodontal epithelia (the tissue linings involved in protecting the mouth and supporting tooth structures), gingiva (gum tissue), salivary glands (which are essential for lubrication, digestion, and antimicrobial defense), and tooth structures. A key part of the rationale is that e-cigarette aerosols are complex mixtures that can vary by device type, operating conditions, and liquid composition, and the oral cavity is a primary point of contact. The FOA encouraged studies that examine how exposure influences biological responses in these oral components, including potentially harmful or adaptive physiological changes.
In addition to direct tissue and organ effects, the announcement also highlighted the oral microbiome as an area of interest. This includes research exploring whether and how e-cigarette aerosol exposure alters the composition or function of microbial communities in the mouth. Because the oral microbiome plays a major role in dental caries, periodontal disease, mucosal health, inflammation, and even systemic health connections, understanding whether e-cigarette aerosols shift microbial balance or behavior was treated as an important scientific gap. In practical terms, this could involve measuring changes in microbial diversity, abundance of specific organisms, biofilm formation, microbial metabolism, or interactions between microbes and host tissues following exposure to aerosol mixtures.
From a funding and administrative standpoint, this was an R21 mechanism, which NIH commonly uses to support exploratory and developmental research projects that can produce proof-of-concept findings or open up new lines of inquiry. The opportunity listed an estimated total funding amount of $2,000,000, with an award ceiling of $150,000. It stated that cost sharing or matching was not required. The activity category was Health, and the CFDA number associated with the program was 93.121 (Oral Diseases and Disorders Research), aligning the FOA with oral health research priorities.
The eligible applicant pool was broad and included many types of U.S. and non-U.S. organizations. Eligible entities included federal, state, county, and local governments; public housing authorities; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits both with and without 501(c)(3) status (excluding higher education where specified); small businesses; and for-profit organizations (including those other than small businesses). The eligibility section also explicitly included a wide range of mission-driven and capacity-building institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based and community-based organizations, tribally affiliated organizations (including some categories beyond federally recognized governments), regional organizations, U.S. territories or possessions, and non-domestic entities (foreign organizations). This broad eligibility reflects NIH’s interest in drawing expertise from many scientific, clinical, and community contexts that can contribute to understanding oral health impacts.
In terms of timeline, the FOA was posted and created on March 5, 2015, with an original and current closing date of July 28, 2015, and an archive date of August 28, 2015. The sponsoring agency was the National Institutes of Health, and the announcement provided an NIH grants webpage link for full details. For technical issues accessing or linking to the full announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, the opportunity was structured to stimulate targeted, mechanistic research on how e-cigarette aerosol mixtures interact with oral tissues and the oral microbiome, generating core biological evidence that could support future, larger studies and contribute to evidence-based decisions in oral health and public policy.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Biological and Physiological Effects of E-cigarette Aerosol Mixtures (R21)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DE-16-005.
Which agency sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
What type of grant mechanism is this?
This was an R21 mechanism, which NIH uses for exploratory and developmental research intended to generate early, proof-of-concept or foundational findings.
What was the main purpose of this FOA?
The core aim was to fund early-stage, exploratory studies that build foundational, evidence-based scientific knowledge about the biological and physiological effects of electronic cigarette (e-cigarette) aerosol mixtures, with a specific emphasis on oral health.
What kinds of research topics did the FOA emphasize?
The FOA emphasized research on how e-cigarette aerosol mixtures affect cells, tissues, and organs within the oral cavity, including mechanistic and measurable biological and physiological effects.
Which oral tissues and structures were specifically highlighted as areas of interest?
The announcement specifically called out:
- Oral and periodontal epithelia (tissue linings involved in protection and tooth-supporting structures)
- Gingiva (gum tissue)
- Salivary glands (important for lubrication, digestion, and antimicrobial defense)
- Tooth structures
Why did the FOA focus on the oral cavity?
The rationale described in the opportunity was that the oral cavity is a primary point of contact for e-cigarette aerosols, and those aerosols are complex mixtures that can vary by device type, operating conditions, and liquid composition.
Did the FOA include the oral microbiome as a research area?
Yes. The FOA highlighted the oral microbiome as an area of interest, including research on whether and how e-cigarette aerosol exposure may alter the composition or function of microbial communities in the mouth.
What kinds of oral microbiome outcomes were described as relevant?
Examples described in the opportunity included measuring changes in:
- Microbial diversity
- Abundance of specific organisms
- Biofilm formation
- Microbial metabolism
- Interactions between microbes and host tissues
What broader health relevance did the FOA connect to oral microbiome research?
The FOA noted that the oral microbiome plays a major role in dental caries, periodontal disease, mucosal health, inflammation, and potential systemic health connections, making it an important scientific gap to address in the context of e-cigarette aerosol exposure.
What was the activity category for this opportunity?
The activity category listed was Health.
What CFDA number was associated with this FOA?
The CFDA number associated with the program was 93.121, labeled Oral Diseases and Disorders Research.
How much total funding was estimated for this FOA?
The opportunity listed an estimated total funding amount of $2,000,000.
What was the award ceiling listed for individual awards?
The listed award ceiling was $150,000.
Was cost sharing or matching required?
No. The opportunity stated that cost sharing or matching was not required.
Who was eligible to apply?
The eligible applicant pool was broad and included many U.S. and non-U.S. organization types. Eligible entities included:
- Federal, state, county, and local governments
- Public housing authorities
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits with and without 501(c)(3) status (excluding higher education where specified)
- Small businesses
- For-profit organizations (including those other than small businesses)
- Non-domestic entities (foreign organizations)
Did the FOA explicitly include specific institution types like HBCUs or Tribal Colleges?
Yes. The eligibility language explicitly included a wide range of institutions and organizations, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Faith-based and community-based organizations
- Tribally affiliated organizations (including categories beyond federally recognized governments)
- Regional organizations
- U.S. territories or possessions
- Non-domestic entities (foreign organizations)
When was the FOA posted and created?
The FOA was posted and created on March 5, 2015.
What was the closing date for applications?
The original and current closing date listed was July 28, 2015.
When was the FOA archived?
The archive date was August 28, 2015.
Where could applicants find full details about the announcement?
The announcement indicated that full details were available via an NIH grants webpage link provided in the FOA.
Who was the contact for technical problems accessing or linking to the full announcement?
For technical issues accessing or linking to the full announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What was the larger goal of generating this evidence?
The opportunity described an intent to generate core biological evidence that could support future, larger studies and help inform public health guidance and health policy decisions related to e-cigarette use, particularly as it impacts oral health.
What does the FOA mean by "e-cigarette aerosol mixtures" being complex?
The FOA described aerosols as complex mixtures that can vary based on device type, operating conditions, and liquid composition, which was part of the reason mechanistic oral health studies were encouraged.
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