Opportunity Information: Apply for DARPA BAA 14 38

  • The Defense Advanced Research Projects Agency in the science and technology and other research and development sector is offering a public funding opportunity titled "Biological Technologies" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.910 Research and Technology Development.
  • This funding opportunity was created on May 1, 2014 and posted on May 1, 2014.
  • Applicants must submit their applications by Apr 30, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for DARPA BAA 14 38

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Opportunity Summary:

DARPA is offering a discretionary research grant opportunity through its Biological Technologies Office (BTO) under Broad Agency Announcement (BAA) 14-38. The core purpose is to fund high-risk, high-reward research that sits at the intersection of biology with engineering and the physical and computer sciences. The program is explicitly not looking for incremental, step-by-step improvements to existing methods. Instead, it is looking for unconventional ideas that challenge standard assumptions, could reset what is considered possible, and potentially open up entirely new technical directions or fields.

A major theme is transforming how the Department of Defense and the broader research community understand, measure, and engineer biological systems. DARPA emphasizes approaches that are creative and agile not only in the technology itself, but also in how teams are organized and how the work is executed. BTO also signals a strong interest in building new technical communities, including drawing innovation from outside traditional DoD contractor and performer networks. In practice, that means proposals can come from a wide range of organizations and disciplines, and multi-disciplinary teams are a natural fit given the biological-plus-engineering focus.

The topical scope is broad, but the announcement highlights several priority areas. One set of topics focuses on the health, readiness, and performance of military service members, including radical new methods to restore and maintain health and capability. Closely related is work that uses neuroscience, psychology, cognitive science, and adjacent fields to improve neurological health, resilience, and human performance, with an emphasis on novel mechanisms, new treatment concepts, or new ways to optimize aptitude under stress. Another emphasis is improving how humans interface with complex environments, including the physical and biological world, which can include advanced sensing, adaptive systems, human-machine teaming, or other interface concepts that enable better performance in demanding operational settings.

On the foundational science and engineering side, BTO is interested in uncovering the design rules that govern biological behavior and then turning that understanding into practical capabilities. This includes new tools and techniques for "forward engineering" biology, meaning the deliberate design and construction of biological systems such as cells, tissues, organs, or whole organisms. The intent is both to create new functional systems or products and to use engineered systems as a way to test hypotheses and reveal underlying biological mechanisms. Computational approaches are also a key pillar: proposals may leverage computer science, big data methods, and biology to extract knowledge from biological data at scale, along with new theories and computational models that explain collective behavior across levels of organization, from cells to individuals to ecosystems.

The opportunity also points to interest in population-level and ecosystem dynamics, especially identifying inflection points where systems shift abruptly. Understanding those thresholds could support maintaining stability, avoiding catastrophic outcomes, or creating strategic opportunities. In parallel, DARPA highlights non-human biology as an innovation source, including insights drawn from microbes, plants, marine life, and other organisms, particularly across populations and environments. Another distinctly cross-cutting topic is how social, environmental, and biological factors interact to contribute to violence and conflict or, conversely, deterrence and influence, reflecting an interest in complex systems where human behavior and biology intersect with environmental pressures.

Finally, the announcement calls for radical new countermeasure approaches for biological, chemical, and/or radiological threats, again with the same emphasis on disruptive rather than incremental advances. It also leaves room for other biological technology areas as long as they align with BTOs mission and fit the BAA scope, effectively inviting applicants to propose bold ideas that may not fit neatly into a predefined category.

Administratively, the funding opportunity number is DARPA BAA 14-38, titled "Biological Technologies," offered as a grant within the Science and Technology and other Research and Development activity category (CFDA 12.910). There is no cost-sharing or matching requirement. Eligibility is listed as unrestricted, meaning it is broadly open to applicant types, subject to any additional eligibility clarifications in the full announcement. The opportunity was posted May 1, 2014, with an original and current closing date of April 30, 2015, and an archive date of May 30, 2015. For access issues or questions about the announcement, the listed contact is the BAA Administrator at DARPA/BTO, 675 North Randolph Street, Arlington, VA 22203-2114.

FAQs: DARPA BTO Broad Agency Announcement (BAA) 14-38 - Biological Technologies

What is this grant opportunity?

This is a discretionary research grant opportunity from DARPA's Biological Technologies Office (BTO) under Broad Agency Announcement (BAA) 14-38, titled "Biological Technologies."

What is the main purpose of DARPA BTO BAA 14-38?

The purpose is to fund high-risk, high-reward research at the intersection of biology with engineering and the physical and computer sciences. The announcement emphasizes unconventional ideas that challenge standard assumptions and could open entirely new technical directions or fields.

What kind of work is DARPA explicitly NOT looking for?

The announcement explicitly states it is not seeking incremental, step-by-step improvements to existing methods. Proposals should aim for disruptive advances rather than straightforward extensions of current approaches.

What themes and research approach does the program emphasize?

DARPA emphasizes transforming how the Department of Defense and the broader research community understand, measure, and engineer biological systems. It also highlights creative and agile approaches not only in the technology, but in how teams are organized and how the work is executed.

Is DARPA interested in new or non-traditional performer communities?

Yes. The announcement signals strong interest in building new technical communities and drawing innovation from outside traditional DoD contractor and performer networks.

Who is eligible to apply?

Eligibility is listed as unrestricted, meaning it is broadly open to applicant types, subject to any additional eligibility clarifications in the full announcement.

Is cost sharing or matching required?

No. There is no cost-sharing or matching requirement stated for this opportunity.

What research areas are highlighted as priorities?

The topical scope is broad, but the announcement highlights priority areas including: service member health and performance; neuroscience, psychology, and cognitive science for neurological health and resilience; improved human interaction with complex environments; foundational design rules of biology and forward engineering of biological systems; computational and big-data approaches to biological understanding; population and ecosystem dynamics; non-human biology as an innovation source; interactions among social, environmental, and biological factors in violence/conflict or deterrence/influence; and radical countermeasures for biological, chemical, and/or radiological threats.

Does the announcement focus on military service member health and readiness?

Yes. A major set of topics includes radical new methods to restore and maintain the health, readiness, and performance of military service members.

Does this opportunity include neuroscience and human performance research?

Yes. It specifically mentions neuroscience, psychology, cognitive science, and related fields to improve neurological health, resilience, and human performance, emphasizing novel mechanisms, new treatment concepts, and new ways to optimize aptitude under stress.

What does "improving how humans interface with complex environments" mean in this announcement?

The announcement notes interest in improving human interaction with complex environments, including the physical and biological world. Examples given include advanced sensing, adaptive systems, human-machine teaming, and other interface concepts that enable better performance in demanding operational settings.

What does DARPA mean by uncovering "design rules" in biology?

This refers to discovering the governing principles behind biological behavior and then translating that understanding into practical capabilities.

What is meant by "forward engineering" of biology?

"Forward engineering" is described as the deliberate design and construction of biological systems such as cells, tissues, organs, or whole organisms. The intent includes creating new functional systems or products and using engineered systems to test hypotheses and reveal underlying biological mechanisms.

Are computational approaches encouraged?

Yes. The announcement highlights proposals that combine computer science, big-data methods, and biology to extract knowledge from biological data at scale, as well as new theories and computational models explaining collective behavior across levels of organization (from cells to individuals to ecosystems).

Does the scope include population-level or ecosystem dynamics?

Yes. It highlights interest in population-level and ecosystem dynamics, especially identifying inflection points where systems shift abruptly. Understanding such thresholds could support maintaining stability, avoiding catastrophic outcomes, or creating strategic opportunities.

Is non-human biology part of the innovation scope?

Yes. DARPA calls out non-human biology as a source of innovation, including insights from microbes, plants, marine life, and other organisms, particularly across populations and environments.

Does the announcement include research related to violence, conflict, deterrence, or influence?

Yes. It identifies a cross-cutting topic on how social, environmental, and biological factors interact in ways that contribute to violence and conflict or, conversely, deterrence and influence.

Are countermeasures for threats included?

Yes. The announcement calls for radical new countermeasure approaches for biological, chemical, and/or radiological threats, with the same emphasis on disruptive rather than incremental advances.

Can applicants propose ideas outside the listed topic areas?

Yes. The opportunity leaves room for other biological technology areas as long as they align with BTO's mission and fit within the BAA scope, effectively inviting bold ideas that may not fit neatly into predefined categories.

What is the funding opportunity number and title?

The funding opportunity number is DARPA BAA 14-38, and the title is "Biological Technologies."

What is the CFDA number and activity category?

The CFDA number is 12.910. The activity category is listed as Science and Technology and other Research and Development.

When was the opportunity posted and when did it close?

It was posted on May 1, 2014. The original and current closing date is listed as April 30, 2015. The archive date is May 30, 2015.

Who can be contacted for access issues or questions about the announcement?

The listed contact is the BAA Administrator at DARPA/BTO, 675 North Randolph Street, Arlington, VA 22203-2114.

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