Opportunity Information: Apply for PA 07 393
Apply for PA 07 393
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biology of Manual Therapies (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health.
- This funding opportunity was created on Dec 5, 2008 and posted on Jun 29, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) City or township governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Public and State controlled institutions of higher education State governments Independent school districts Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses.
- Foreign institutions are eligible to apply.
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Opportunity Summary:
The Biology of Manual Therapies (R01) opportunity (Funding Opportunity Number PA 07 393) is a National Institutes of Health discretionary grant program designed to move manual therapy research beyond clinical outcomes and into clear, testable biology. The central aim is to support high-quality basic science and mechanistic studies that explain how commonly used hands-on interventions such as spinal manipulation, mobilization, and massage therapy produce measurable effects in the body. The FOA explicitly highlights several biological domains of interest, including biomechanical effects (for example, forces, tissue deformation, joint mechanics, and resulting functional changes), immunological responses (such as inflammatory mediators or immune signaling), endocrinological consequences (hormonal or stress-response pathways), and neurophysiological mechanisms (including nervous system signaling, pain processing, reflex pathways, and central or peripheral nervous system modulation). In practical terms, NIH is looking for rigorous projects that can connect a defined manual therapy input to specific biological changes, helping establish plausible mechanisms of action rather than relying on broad or nonspecific explanations.
The funding mechanism is the NIH Research Project Grant (R01), which is typically used for substantial, hypothesis-driven research programs that can support a multi-year, well-developed line of investigation. This FOA runs in parallel with another announcement of the same scientific scope that uses the R21 mechanism (PAR 06 312), which generally supports earlier-stage or exploratory work. Applicants should interpret the R01 track as appropriate for projects with strong preliminary data, a clearly articulated research plan, and methods capable of producing definitive mechanistic evidence. NIH does not set a single fixed award size or project period under this announcement; instead, the budget and duration are expected to vary based on what the proposed science actually requires. Likewise, NIH does not promise a specific number of awards. The total amount awarded and the number of funded projects depend on the quality of applications received, their costs, and their proposed timelines.
Eligibility is broad and includes many types of domestic applicants: federally recognized Native American tribal governments and tribal organizations, state and local governments (including counties, cities/townships, special districts, and independent school districts), public and state-controlled universities, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, public housing authorities/Indian housing authorities, small businesses, and for-profit organizations (with the note that small businesses are explicitly listed, while other for-profits are also listed as eligible except small businesses, implying multiple for-profit pathways depending on organizational category). A notable feature is that foreign institutions are eligible to apply, which widens the pool to international research teams capable of conducting strong mechanistic studies. There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of receiving an award.
Administratively, the FOA was posted June 29, 2007, and indicates multiple receipt dates rather than a single deadline, directing applicants to the full announcement for the specific submission cycles. The opportunity was archived June 7, 2010, which matters for anyone looking to apply today because it suggests this particular FOA is no longer active in its original form; however, the scientific concept may continue under newer NIH notices or related NCCIH/NIH funding opportunities. The program is associated with CFDA numbers 93.213 (Research and Training in Complementary and Integrative Health) and 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health), reflecting NIH interest both in complementary/integrative health research and in technology-enabled approaches that improve health outcomes. For applicants needing technical help accessing the full announcement, the listed contact is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is primarily for access and linking issues rather than scientific questions.
Overall, this grant opportunity targets investigators who can bring strong experimental design, quantitative measurement, and biological expertise to manual therapy questions, with the goal of producing mechanistic evidence about how manual interventions influence body systems relevant to pain, function, and physiological regulation.
Frequently Asked Questions (FAQs): The Biology of Manual Therapies (R01) - PA 07 393
What is the purpose of the Biology of Manual Therapies (R01) funding opportunity?
This NIH discretionary grant opportunity is intended to move manual therapy research beyond clinical outcomes and into clear, testable biology. The focus is on high-quality basic science and mechanistic studies that can explain how hands-on interventions produce measurable biological effects in the body.
What kinds of manual therapies are relevant under this FOA?
The opportunity explicitly references commonly used hands-on interventions such as spinal manipulation, mobilization, and massage therapy. In general, the emphasis is on defined manual therapy inputs that can be linked to specific biological changes.
What does NIH mean by "mechanistic" research in this context?
In this FOA, mechanistic research means studies designed to connect a defined manual therapy intervention to specific, measurable biological changes. The goal is to establish plausible mechanisms of action with rigorous experimental design, rather than relying on broad, nonspecific, or purely descriptive explanations.
What biological domains or mechanisms are highlighted as areas of interest?
The FOA highlights several domains of interest, including:
- Biomechanical effects (for example, forces, tissue deformation, joint mechanics, and related functional changes)
- Immunological responses (such as inflammatory mediators or immune signaling)
- Endocrinological consequences (hormonal effects and stress-response pathways)
- Neurophysiological mechanisms (nervous system signaling, pain processing, reflex pathways, and central/peripheral nervous system modulation)
Is this opportunity focused on clinical outcomes or biological explanations?
The emphasis is on biological explanations and measurable mechanisms. While manual therapies are often studied through clinical outcomes, this FOA is aimed at projects that can produce definitive mechanistic evidence about how these interventions influence body systems.
What grant mechanism is used for this opportunity?
The funding mechanism is the NIH Research Project Grant (R01), which is typically used for substantial, hypothesis-driven research programs that support multi-year, well-developed lines of investigation.
How does this R01 opportunity relate to the R21 announcement mentioned?
This FOA runs in parallel with another announcement that uses the R21 mechanism (PAR 06 312) and shares the same general scientific scope. The R01 track is positioned for more substantial, well-developed projects, while the R21 is generally associated with earlier-stage or exploratory work.
What type of project is most appropriate for the R01 track described here?
Based on the FOA description, the R01 track is best suited for projects with strong preliminary data, a clearly articulated research plan, and methods capable of producing definitive mechanistic evidence about manual therapy inputs and biological effects.
Is there a fixed award amount or fixed project period?
No. NIH does not set a single fixed award size or project period under this announcement. Budgets and durations are expected to vary based on what the proposed science requires.
Does NIH guarantee a specific number of awards?
No. NIH does not promise a specific number of awards. The number of funded projects and the total amount awarded depend on the quality of applications received, their proposed costs, and their timelines.
Who is eligible to apply?
Eligibility is broad and includes many types of applicants, including:
- Federally recognized Native American tribal governments and tribal organizations
- State and local governments (including counties, cities/townships, special districts, and independent school districts)
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- Public housing authorities / Indian housing authorities
- Small businesses
- For-profit organizations (noting the FOA lists multiple for-profit pathways/categories)
Are foreign institutions eligible to apply?
Yes. A notable feature of this opportunity is that foreign institutions are eligible to apply, allowing international research teams to submit mechanistic manual therapy studies.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement under this FOA, meaning applicants are not required to provide non-federal matching funds as a condition of receiving an award.
When was this FOA posted, and does it have one deadline?
The FOA was posted on June 29, 2007. It indicates multiple receipt dates rather than a single deadline and directs applicants to the full announcement for specific submission cycles.
Is this FOA still active?
The opportunity was archived on June 7, 2010. That archiving status suggests the FOA is no longer active in its original form. The scientific concept may still continue through newer NIH notices or related funding opportunities, but that determination would require checking current NIH opportunities.
What are the CFDA numbers associated with this program?
The FOA is associated with CFDA numbers 93.213 (Research and Training in Complementary and Integrative Health) and 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health).
What do the CFDA numbers suggest about the program's emphasis?
They reflect NIH interest in complementary and integrative health research as well as discovery and applied research that can improve human health, including technology-enabled or innovation-oriented approaches where relevant to the proposed mechanistic science.
Where can applicants get technical help accessing the full announcement?
For technical help related to accessing or linking to the full announcement, the FOA lists the NIH Office of Extramural Research (OER) webmaster: FBOWebmaster@OD.NIH.GOV. This contact is described as primarily for access and linking issues rather than scientific questions.
What is NIH trying to see in successful applications under this FOA?
The FOA points toward rigorous projects that use strong experimental design and quantitative measurement to connect a defined manual therapy input to specific biological changes. The overarching goal is mechanistic evidence explaining how manual interventions influence body systems relevant to pain, function, and physiological regulation.
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Applicants who have applied for this opportunity (PA 07 393) also looked into and applied for these:
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| Outcomes in Children with Mild to Severe Hearing Loss (R01) Apply for PA 07 394 Funding Number: PA 07 394 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Young Children with Mild to Severe Hearing Loss (R21) Apply for PA 07 400 Funding Number: PA 07 400 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Screening and Brief Alcohol Interventions in Underage and Young Adult Populations (R01) Apply for PA 07 406 Funding Number: PA 07 406 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Screening and Brief Alcohol Interventions in Underage and Young Adult Populations (R21) Apply for PA 07 407 Funding Number: PA 07 407 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Screening and Brief Alcohol Interventions in Underage and Young Adult Populations (R03) Apply for PA 07 408 Funding Number: PA 07 408 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Bridges to the Doctorate Program (R25) Apply for PAR 07 410 Funding Number: PAR 07 410 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Bridges to the Baccalaureate Program (R25) Apply for PAR 07 411 Funding Number: PAR 07 411 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCR Small Grant Program for New Investigators (R03) Apply for PAR 07 418 Funding Number: PAR 07 418 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Research on Alcohol Related Public Policies such as Those Detailed in the Alcohol Policy Information System (R01) Apply for PA 07 427 Funding Number: PA 07 427 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Research on Alcohol Related Public Policies such as Those Detailed in the Alcohol Policy Information System (R03) Apply for PA 07 429 Funding Number: PA 07 429 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIGMS Postbaccalaureate Research Education Program (PREP) R25 Apply for PAR 07 432 Funding Number: PAR 07 432 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Research on Interventions for Child Abuse and Neglect (R01) Apply for PA 07 437 Funding Number: PA 07 437 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Epidemiology and Prevention in Alcohol Research (R01) Apply for PA 07 448 Funding Number: PA 07 448 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Epidemiology and Prevention in Alcohol Research (R21) Apply for PA 07 449 Funding Number: PA 07 449 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Epidemiology and Prevention in Alcohol Research (R03) Apply for PA 07 450 Funding Number: PA 07 450 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Diversity Research Education Grants in Neuroscience (R25) Apply for PAR 07 456 Funding Number: PAR 07 456 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Technology and Methods Development for Genomics, Population Genomics and ELSI (R01) Apply for PA 07 458 Funding Number: PA 07 458 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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