Opportunity Information: Apply for PA 14 358
Apply for PA 14 358
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biology of the Temporomandibular Joint in Health and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health.
- This funding opportunity was created on Oct 3, 2014 and posted on Oct 3, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal governments (Federally recognized) Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Biology of the Temporomandibular Joint in Health and Disease (R01) (Funding Opportunity Number PA-14-358) is an NIH research project grant opportunity designed to push the field toward a deeper, more integrated understanding of how the temporomandibular joint (TMJ) works in normal conditions and what goes wrong in temporomandibular joint disorders (TMD). The core goal is to stimulate studies that build on and complement prior TMJ efforts, with a strong emphasis on the underlying biology of joint function and the specific tissues that make up the TMJ. The announcement highlights a need to move beyond isolated tissue observations and instead examine the TMJ as a whole functional unit, including its structure and mechanics, and how those features are shaped by interactions across multiple body systems.
A central theme of the opportunity is systems-level and mechanistic research. NIH is explicitly looking for work that improves understanding of total joint structure and biomechanics, including how the skeletal components of the joint interact with surrounding muscles and how neural, immune, and circulatory factors contribute to joint health, adaptation, degeneration, pain, and dysfunction. The FOA signals that progress in the field depends on newer experimental approaches, especially improved in vivo and in vitro models that better replicate real TMJ function, loading, tissue interfaces, and multi-system influences. In practical terms, the work encouraged here can span basic biology, translational mechanisms, and model development, as long as it clearly advances knowledge about TMJ function in health and disease.
The expected payoff from projects supported under this FOA is new foundational knowledge that can be used to develop better clinical approaches for TMD. NIH frames that outcome broadly: the research should help create a stronger scientific basis for preventing TMJ problems, improving diagnosis, identifying and assessing risk, and ultimately designing more effective treatments. The underlying message is that clinical progress has been limited by gaps in understanding of TMJ tissue biology and joint mechanics, and that addressing those gaps could unlock more targeted, evidence-based strategies for care.
From an administrative standpoint, this is a discretionary grant opportunity using the NIH R01 mechanism, which is typically intended for hypothesis-driven, investigator-initiated research projects of substantial scope. The activity category is health-related research, and the CFDA numbers associated with the program include 93.121 (Oral Diseases and Disorders Research) and 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health). Cost sharing or matching is not required, which means applicants are not expected to commit non-federal funds as a condition of the award.
Eligibility is broad and includes many types of domestic and international applicants. Eligible organizations span public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses) and small businesses, independent school districts, and various government entities (state, county, city/township, special district, and certain housing authorities). The FOA also calls out eligibility for a range of mission- and community-focused institutions and organizations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based and community-based organizations where appropriate. Importantly, non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by NIH policy are allowed, which opens the door for international collaboration and study populations where scientifically justified.
The opportunity was posted and created on October 3, 2014, with an original and current closing date of September 7, 2017, and an archive date of October 8, 2017, indicating the announcement is no longer active for new submissions under that specific posting. The sponsoring agency is the National Institutes of Health, and the full announcement was available through the NIH Grants Guide (linked in the source information). For technical access issues, the contact listed is the NIH Office of Extramural Research webmaster (FBOWebmaster@od.nih.gov).
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled Biology of the Temporomandibular Joint in Health and Disease (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-14-358.
Which agency is sponsoring this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is being used?
This opportunity uses the NIH R01 mechanism, described as a discretionary NIH research project grant typically used for hypothesis-driven, investigator-initiated research projects of substantial scope.
What is the main scientific purpose of this FOA?
The FOA is designed to push the field toward a deeper, more integrated understanding of how the temporomandibular joint (TMJ) functions in health and what goes wrong in temporomandibular joint disorders (TMD), with an emphasis on the underlying biology of joint function and the specific tissues that make up the TMJ.
What kinds of research approaches does NIH emphasize in this announcement?
The announcement emphasizes systems-level and mechanistic research and encourages studies that examine the TMJ as a whole functional unit, rather than focusing only on isolated tissue observations.
Does the FOA encourage studying TMJ structure and biomechanics?
Yes. NIH explicitly highlights the importance of improving understanding of total joint structure and biomechanics, including how joint tissues and mechanics contribute to health, adaptation, degeneration, pain, dysfunction, and disease.
What interactions or body systems are specifically called out as important to TMJ research in this FOA?
The FOA calls out interactions involving skeletal components and surrounding muscles, as well as contributions from neural, immune, and circulatory factors to TMJ health and disease-related outcomes such as pain and dysfunction.
Is the FOA limited to basic research only?
No. The FOA indicates the work can span basic biology, translational mechanisms, and model development, as long as the project clearly advances knowledge about TMJ function in health and disease.
Does NIH express a need for improved models?
Yes. NIH points to the need for newer experimental approaches, including improved in vivo and in vitro models that better replicate real TMJ function, loading, tissue interfaces, and multi-system influences.
What outcomes or longer-term impact does NIH expect from projects supported under this FOA?
The expected payoff is new foundational knowledge that can support better clinical approaches for TMD, including strengthening the scientific basis for prevention, improved diagnosis, risk identification and assessment, and development of more effective treatments.
Why does NIH say this research area needs additional progress?
The FOA states that clinical progress has been limited by gaps in understanding of TMJ tissue biology and joint mechanics, and that addressing these gaps could enable more targeted, evidence-based strategies for care.
What is the activity category for this opportunity?
The activity category is health-related research.
What CFDA numbers are associated with this program?
The CFDA numbers listed are 93.121 (Oral Diseases and Disorders Research) and 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health).
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required, meaning applicants are not expected to commit non-federal funds as a condition of the award.
Who is eligible to apply?
Eligibility is described as broad and includes a wide range of domestic and international applicants, spanning higher education, nonprofit, for-profit, small business, school district, and government organizations.
Are U.S. colleges and universities eligible?
Yes. Eligible applicants include public and private institutions of higher education.
Are nonprofit organizations eligible, including those without 501(c)(3) status?
Yes. The FOA includes nonprofits with and without 501(c)(3) status among eligible organizations.
Are for-profit organizations eligible?
Yes. The FOA includes for-profit organizations (other than small businesses), and also separately includes small businesses.
Are government entities eligible to apply?
Yes. Eligibility includes various government entities such as state, county, city/township, special district, and certain housing authorities.
Are independent school districts eligible?
Yes. Independent school districts are included in the eligible organization types.
Does the FOA specifically mention eligibility for mission- and community-focused institutions?
Yes. The FOA calls out eligibility for institutions and organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based and community-based organizations where appropriate.
Are foreign organizations eligible to apply?
Yes. The FOA states that non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA states that non-U.S. components of U.S. organizations are eligible.
Are foreign components (as defined by NIH policy) permitted?
Yes. The FOA notes that foreign components as defined by NIH policy are allowed, supporting international collaboration and scientifically justified international study elements.
When was this opportunity posted?
The opportunity was posted and created on October 3, 2014.
What was the closing date for submissions under this posting?
The FOA lists an original and current closing date of September 7, 2017.
Is this FOA still active?
No. The FOA has an archive date of October 8, 2017, indicating the announcement is no longer active for new submissions under that specific posting.
Where was the full announcement made available?
The full announcement was available through the NIH Grants Guide (as referenced in the source information).
Who should be contacted for technical access issues related to the announcement?
For technical access issues, the listed contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@od.nih.gov.
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