Opportunity Information: Apply for RFA AA 11 005
Apply for RFA AA 11 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biomarkers of Alcohol Consumption and Alcohol induced Tissue Injury (STTR R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 27, 2010 and posted on Aug 26, 2010.
- Applicants must submit their applications by Nov 2, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The Biomarkers of Alcohol Consumption and Alcohol-induced Tissue Injury (STTR R41/R42) funding opportunity (RFA-AA-11-005) is a National Institutes of Health (NIH) discretionary grant announcement aimed at pushing new, practical biomarker tools closer to real-world clinical use. The core goal is to spur small business-led research that identifies and develops measurable biological indicators related to alcohol use and its harmful effects. In particular, the FOA is focused on three major biomarker needs: biomarkers that objectively reflect alcohol consumption, biomarkers that can detect alcohol-induced organ damage at an early stage (before severe disease is obvious), and biomarkers that can indicate fetal alcohol exposure.
A central theme of the announcement is discovery and development that can move beyond basic research into something that could plausibly become a usable test. The NIH is explicitly encouraging applications that use high-throughput technologies to uncover biomarker signatures rather than relying on one-off, low-scale approaches. In practice, this points applicants toward platforms and strategies such as omics-based profiling (for example, proteomics, metabolomics, transcriptomics, epigenomics), multiplexed assays, or other broad screening methods that can identify patterns associated with drinking behavior, tissue injury, or prenatal exposure. Just as importantly, the FOA emphasizes translation: projects that can take promising biomarker candidates and move them toward marketable, clinically useful assays are viewed favorably. That translation emphasis implies attention not only to discovery, but also to early validation, assay feasibility, reproducibility, and potential pathways to adoption in clinical or public health settings.
This opportunity uses the Small Business Technology Transfer (STTR) mechanism, specifically the Phase I R41 award structure under this announcement. It is designed for small business concerns (SBCs) as the eligible applicant category, with the broader expectation that STTR projects involve a formal collaboration between the small business and a nonprofit research institution, consistent with STTR program rules. The announcement runs in parallel with a companion solicitation (RFA-AA-11-004) that targets similar scientific goals but through the SBIR mechanism (R43/R44), giving small businesses two related pathways depending on their structure and commercialization plan. A key limitation here is that Phase II and Fast-Track applications are not accepted under this particular FOA, meaning the competition is confined to Phase I under the STTR approach.
On funding and scale, NIH estimated total support of about $500,000 for fiscal year 2011 to make roughly 2 to 4 awards under this announcement, with an award ceiling listed at $200,000. The FOA notes that future year amounts would depend on annual appropriations, so the stated funding level reflects the specific budget expectation at the time the announcement was issued rather than a guaranteed multi-year commitment. The program falls under CFDA 93.273 (Alcohol Research Programs), does not require cost sharing or matching, and is administered by NIH.
Key timing and administrative details include a posted date of August 26, 2010, with an original and current closing date of November 2, 2010, and an archive date of December 3, 2010. The official NIH guide link was provided for full instructions and requirements (http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-11-005.html). For access or technical issues with the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV. Overall, the opportunity is best understood as a targeted push for small businesses to combine modern, high-throughput biomarker discovery with a realistic plan to convert promising biomarker signatures into clinically deployable tests related to alcohol consumption, alcohol-related tissue injury, and fetal alcohol exposure.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Biomarkers of Alcohol Consumption and Alcohol-induced Tissue Injury (STTR R41/R42)" and is identified as RFA-AA-11-005.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant announcement.
What is the main purpose of RFA-AA-11-005?
The core goal is to support small business-led research that identifies and develops measurable biological indicators (biomarkers) related to alcohol use and alcohol-related harm, with an emphasis on moving practical biomarker tools closer to real-world clinical use.
What kinds of biomarkers is the FOA specifically trying to advance?
The FOA highlights three major biomarker needs:
- Biomarkers that objectively reflect alcohol consumption
- Biomarkers that can detect alcohol-induced organ damage early (before severe disease is obvious)
- Biomarkers that can indicate fetal alcohol exposure
Is this opportunity more about basic research or about translation to real-world tests?
The announcement emphasizes translation. It encourages discovery and development that can move beyond basic research into something that could plausibly become a usable test, including attention to early validation, assay feasibility, reproducibility, and pathways to adoption in clinical or public health settings.
Does the FOA encourage high-throughput biomarker discovery methods?
Yes. NIH explicitly encourages applications that use high-throughput technologies to uncover biomarker signatures rather than one-off, low-scale approaches.
What examples of high-throughput approaches are mentioned or implied?
The FOA points applicants toward platforms and strategies such as omics-based profiling (including proteomics, metabolomics, transcriptomics, and epigenomics), multiplexed assays, and other broad screening methods capable of identifying patterns associated with drinking behavior, tissue injury, or prenatal exposure.
What grant mechanism does this opportunity use?
This opportunity uses the Small Business Technology Transfer (STTR) mechanism and focuses on the Phase I R41 award structure under this announcement.
Who is eligible to apply?
The eligible applicant category is small business concerns (SBCs).
Does the STTR mechanism require collaboration with a research institution?
Yes. The announcement notes an expectation of a formal collaboration between the small business and a nonprofit research institution, consistent with STTR program rules.
Are Phase II or Fast-Track applications allowed under this FOA?
No. Phase II and Fast-Track applications are not accepted under this particular FOA. The competition is confined to Phase I under the STTR approach.
Is there a companion NIH opportunity related to this topic?
Yes. A companion solicitation (RFA-AA-11-004) targets similar scientific goals but uses the SBIR mechanism (R43/R44), offering another pathway depending on a small business's structure and commercialization plan.
How much total funding did NIH estimate for this announcement?
NIH estimated total support of about $500,000 for fiscal year (FY) 2011 under this announcement.
How many awards were expected to be made?
The FOA estimated roughly 2 to 4 awards.
What is the award ceiling listed in the FOA?
The award ceiling listed is $200,000.
Is the stated funding level guaranteed in future years?
No. The FOA notes that future year amounts depend on annual appropriations, so the stated funding reflects the budget expectation at the time the announcement was issued rather than a guaranteed multi-year commitment.
What CFDA program does this opportunity fall under?
The program falls under CFDA 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
When was the announcement posted?
The posted date is August 26, 2010.
What was the closing date for applications?
The original and current closing date listed is November 2, 2010.
When was the opportunity archived?
The archive date is December 3, 2010.
Where can applicants find the official NIH guide notice and full instructions?
The FOA points to the official NIH guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-11-005.html
Who is listed as the contact for access or technical issues with the announcement?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What kind of project focus would be viewed favorably based on the FOA description?
Projects that combine modern high-throughput biomarker discovery with a realistic plan to advance promising biomarker signatures toward clinically deployable, marketable assays (including considerations like validation, feasibility, and reproducibility) are emphasized as aligned with the FOA's goals.
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