Opportunity Information: Apply for RFA AG 15 011
Apply for RFA AG 15 011
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Biomarkers of Alzheimers Disease in Down Syndrome (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Aug 28, 2014 and posted on Aug 28, 2014.
- Applicants must submit their applications by Jan 12, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,500,000.00 in funding.
- Eligible applicants include: County governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses Independent school districts City or township governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Biomarkers of Alzheimers Disease in Down Syndrome (R01) opportunity (Funding Opportunity Number RFA-AG-15-011) is a discretionary National Institutes of Health (NIH) grant program focused on improving how Alzheimers disease is tracked and understood over time in adults who have Down Syndrome. The central aim is to support research that can map the longitudinal progression of Alzheimers disease in this population by using multiple types of biomarkers and assessments together, including clinical measures, cognitive testing, brain imaging, genetic markers, and biochemical indicators. In practical terms, the opportunity is designed to help researchers identify which measurable signals change as Alzheimers develops and progresses in adults with Down Syndrome, and how those signals relate to real-world clinical and cognitive changes across time.
This program uses the R01 research project grant mechanism, meaning it is intended for substantial, hypothesis-driven projects with clearly defined research plans, robust methodology, and meaningful outcomes that can advance the field. Projects supported under this announcement would typically involve repeated measurements in the same individuals across multiple time points, which is what makes the work "longitudinal." The overall scientific emphasis is not just on finding potential biomarkers in a single snapshot, but on determining how a set of biomarkers evolves, which ones predict meaningful disease milestones, and how different biomarker categories (for example, imaging plus blood-based measures plus cognitive change) can be combined to better characterize disease trajectory.
The funding announcement was posted and created on August 28, 2014, with an original and final application due date of January 12, 2015, and an archive date of February 12, 2015. The estimated total program funding listed is $5,000,000, and the award ceiling is $2,500,000, indicating that the NIH expected to make a limited number of relatively large awards or a small set of moderate awards, depending on application quality and program priorities. There is no cost sharing or matching requirement, so applicants were not required to commit non-federal funds as a condition of receiving an award.
In terms of who could apply, eligibility is broad and includes many types of U.S. organizations and governments, as well as international entities. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, and public housing authorities (including Indian housing authorities). Academic institutions are eligible, including public and state-controlled institutions of higher education and private institutions of higher education. The announcement also allows applications from nonprofit organizations (both those with 501(c)(3) status and those without), and from for-profit organizations (including small businesses and other for-profit entities that are not small businesses). Tribal organizations are included, both federally recognized and other than federally recognized tribal governments, along with tribally controlled colleges and universities.
The eligibility language also explicitly includes a range of institution types that NIH often seeks to encourage, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), and faith-based or community-based organizations, among others. Importantly, foreign organizations and other non-U.S. entities are eligible to apply, non-U.S. components of U.S. organizations may participate, and foreign components are permitted as defined by the NIH Grants Policy Statement. This broad eligibility suggests the NIH intended to attract the strongest possible science and to enable multinational collaboration when it improves access to cohorts, specialized expertise, or unique data resources.
The opportunity is categorized under Health, Income Security and Social Services, and it is linked to CFDA numbers 93.865 (Child Health and Human Development Extramural Research) and 93.866 (Aging Research), reflecting the cross-cutting nature of Down Syndrome research and Alzheimers disease research. While the announcement title emphasizes Alzheimers disease and Down Syndrome, the underlying rationale is that adults with Down Syndrome represent a critically important population for studying Alzheimers-related brain changes, and that better biomarkers can strengthen diagnosis, staging, prognosis, and the design of clinical trials by providing measurable indicators of disease activity and progression.
For applicants or researchers seeking the official full text, the announcement points to the NIH Grants Guide listing at http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-011.html. The notice also provides technical support contacts through the NIH Office of Extramural Research (OER) webmaster, for situations where applicants have trouble accessing the announcement online or linking to the funding page.
Frequently Asked Questions (FAQs)
What is the Biomarkers of Alzheimers Disease in Down Syndrome (R01) funding opportunity?
It is a discretionary National Institutes of Health (NIH) grant opportunity titled "Biomarkers of Alzheimers Disease in Down Syndrome (R01)," Funding Opportunity Number RFA-AG-15-011. It focuses on research to improve how Alzheimers disease is tracked and understood over time in adults with Down Syndrome using longitudinal, multi-biomarker approaches.
What is the main goal of this program?
The central aim is to support research that maps the longitudinal progression of Alzheimers disease in adults with Down Syndrome by combining multiple biomarkers and assessments (for example, clinical measures, cognitive testing, brain imaging, genetic markers, and biochemical indicators) and relating those signals to clinical and cognitive changes over time.
What does "longitudinal progression" mean in the context of this opportunity?
"Longitudinal" refers to repeated measurements in the same individuals across multiple time points. The program emphasis is on understanding how biomarker signals change as Alzheimers develops and progresses, rather than relying on a single snapshot at one point in time.
What kinds of biomarkers and assessments are expected to be used?
The opportunity highlights integrating multiple types of measures, including clinical measures, cognitive testing, brain imaging, genetic markers, and biochemical indicators. A key theme is combining different biomarker categories to better characterize disease trajectory.
Is the focus on discovering brand-new biomarkers or understanding how biomarkers change over time?
Based on the description provided, the scientific emphasis is not limited to identifying biomarkers at a single time point. It is strongly oriented toward determining how a set of biomarkers evolves over time, which markers predict meaningful disease milestones, and how combined biomarker signals relate to real-world clinical and cognitive change.
What grant mechanism is used for this opportunity?
This program uses the NIH R01 research project grant mechanism, which is intended for substantial, hypothesis-driven projects with clearly defined research plans, robust methodology, and meaningful outcomes that can advance the field.
Who is the population of interest for the research?
The opportunity is focused on adults with Down Syndrome and improving the tracking and understanding of Alzheimers disease development and progression within this population.
When was the funding announcement posted, and what were the key dates?
The announcement was posted and created on August 28, 2014. The original and final application due date was January 12, 2015. The archive date was February 12, 2015.
How much funding was available through this program?
The estimated total program funding listed is $5,000,000.
What is the maximum award size (award ceiling)?
The award ceiling is $2,500,000.
Does this opportunity require cost sharing or matching funds?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants were not required to commit non-federal funds as a condition of receiving an award.
What types of organizations are eligible to apply?
Eligibility is broad and includes many U.S. organizations and governments as well as international entities. Eligible applicants include various government entities (state, county, city or township, special district, independent school districts, and public housing authorities including Indian housing authorities), academic institutions (public/state-controlled and private institutions of higher education), nonprofit organizations (with 501(c)(3) status and without), and for-profit organizations (including small businesses and other for-profit entities).
Are tribal governments and tribally affiliated institutions eligible?
Yes. Eligible applicants include federally recognized tribal governments and tribal governments other than federally recognized, as well as tribally controlled colleges and universities.
Are specific institution types like HBCUs or Hispanic-Serving Institutions included in eligibility?
Yes. The eligibility language explicitly includes institution types NIH often encourages, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). It also includes faith-based or community-based organizations, among others.
Can foreign organizations apply?
Yes. The opportunity states that foreign organizations and other non-U.S. entities are eligible to apply.
Can a U.S. organization include non-U.S. components or foreign components in the project?
Yes. Non-U.S. components of U.S. organizations may participate, and foreign components are permitted as defined by the NIH Grants Policy Statement.
What is the program trying to achieve in practical research terms?
In practical terms, the opportunity is designed to help researchers identify which measurable signals change as Alzheimers develops and progresses in adults with Down Syndrome, and how those signals relate to meaningful clinical and cognitive changes across time.
Why does the announcement emphasize combining multiple biomarker categories?
The description indicates an emphasis on using multiple types of biomarkers and assessments together (for example, imaging plus blood-based measures plus cognitive change) to better characterize disease trajectory and identify signals that predict important disease milestones.
What general topic areas is this opportunity categorized under?
The opportunity is categorized under Health, Income Security and Social Services.
Which CFDA numbers are associated with this opportunity?
The opportunity is linked to CFDA 93.865 (Child Health and Human Development Extramural Research) and 93.866 (Aging Research).
Where can applicants find the official full text of the announcement?
The announcement points to the NIH Grants Guide listing at http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-011.html.
Who should be contacted for technical support accessing the announcement online?
The notice provides technical support contacts through the NIH Office of Extramural Research (OER) webmaster for issues such as trouble accessing the announcement online or linking to the funding page.
What does the combination of total funding and award ceiling suggest about the number or size of awards?
The description notes that a total estimated program funding of $5,000,000 and an award ceiling of $2,500,000 suggests NIH expected to make a limited number of relatively large awards, or a small set of moderate awards, depending on application quality and program priorities.
Is this opportunity still active?
Based on the dates provided (final application due date of January 12, 2015, and archive date of February 12, 2015), this specific funding announcement is archived.
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