Biomarkers of Infection Associated Cancers (R01) | Apply Online

Opportunity Summary:

The Biomarkers of Infection Associated Cancers (R01) opportunity (Funding Opportunity Number PA-08-156) is a National Institutes of Health (NIH) funding announcement led by the National Cancer Institute (NCI) with participation from the National Institute of Dental and Craniofacial Research (NIDCR). Its central goal is to support research projects that identify and develop biomarkers for cancers in which infectious agents play a causal role in disease development. In practical terms, the grant is aimed at helping researchers find measurable biological indicators tied to infection-driven cancers, such as markers that could improve cancer risk prediction, enable earlier detection, support diagnosis, clarify prognosis, or track disease progression and response to therapy in settings where infection is part of the underlying etiology.

This announcement uses the standard NIH Research Project Grant (R01) mechanism, which is generally intended for more mature, hypothesis-driven projects with a defined research plan and a scope that can be sustained over multiple years. The FOA also notes that it runs in parallel with a separate but scientifically identical announcement using the R21 mechanism (PA-08-157). That parallel track matters because it signals NIH is supporting both exploratory early-stage biomarker work (R21) and more fully developed, comprehensive research programs (R01) in the same scientific space, allowing applicants to choose a mechanism that matches the maturity and scale of their proposed work.

The funding category is listed as discretionary, and awards are described as contingent on both the availability of funds and the receipt of a sufficient number of highly meritorious applications. In other words, there is no guaranteed number of awards, and applications compete based on scientific merit and program priorities during the relevant cycles. The activity areas associated with the announcement span cancer cause and prevention, cancer detection and diagnosis, cancer biology, and oral diseases and disorders research, reflecting the involvement of both NCI and NIDCR and the broad relevance of infection-related carcinogenesis across organ systems, including the oral and craniofacial domain.

Eligibility is broad and includes many common NIH applicant types: public and state-controlled institutions of higher education, private institutions of higher education, for-profit organizations (other than small businesses), small businesses, state governments, and nonprofit organizations with or without 501(c)(3) status (with distinctions depending on whether they are institutions of higher education). The FOA also explicitly includes additional eligible applicants such as certain federal agencies, Hispanic-serving institutions, U.S. territories and possessions, regional organizations, and non-U.S. entities (foreign organizations). This broad eligibility framework is consistent with NIH’s interest in supporting biomarker discovery and validation efforts that may require diverse clinical populations, global infectious disease contexts, and specialized laboratory capabilities.

Administratively, the opportunity was posted on April 22, 2008, and ultimately closed on May 7, 2011, with an archive date of June 7, 2011, meaning it is no longer open for new applications but remains as a reference record. There is no cost sharing or matching requirement. The primary agency contact listed for access or linking issues is the NIH Office of Extramural Research (OER) webmaster, and the official full text of the announcement was hosted through the NIH grants guide page referenced in the additional information link.

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