Opportunity Information: Apply for PAR 10 221
Apply for PAR 10 221
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Biophysical and Biomechanical Aspects of Embryonic Development (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.837 Cardiovascular Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Aug 13, 2010 and posted on Jun 25, 2010.
- Applicants must submit their applications by Sep 20, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) For Profit Organizations (Including Small Businesses).
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Opportunity Summary:
The NIH funding opportunity announcement PAR-10-221, titled "Biophysical and Biomechanical Aspects of Embryonic Development (R01)," supports hypothesis-driven research that explains embryonic development through the lens of physics and mechanics. The core aim is to move beyond purely genetic or molecular descriptions of development by focusing on how forces, material properties, and physical constraints shape tissues and organs as embryos form. The participating NIH institutes include the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institute of General Medical Sciences (NIGMS), and the National Heart, Lung, and Blood Institute (NHLBI), reflecting an interest that spans fundamental developmental biology, engineering and imaging technology, basic biomedical science, and organ systems such as the cardiovascular and pulmonary systems.
This announcement specifically invites R01 Research Project Grant applications that can generate new, critical insight into tissue mechanics in vertebrate development and, importantly, how disruptions in these mechanical processes may contribute to developmental disorders. In practice, projects responsive to this FOA would typically connect measurable physical or biomechanical phenomena (for example, tissue stiffness, cell-generated forces, morphogenetic movements, fluid dynamics, or mechanical signaling) to developmental outcomes such as shaping of organs, pattern formation, or structural defects. The emphasis is on advancing knowledge of "developmental tissue mechanics" in ways that have clear biological relevance and can illuminate mechanisms behind abnormal development, not simply describing mechanics in isolation.
A major theme in the FOA is innovation in approach. Investigators are encouraged to introduce concepts, models, and methods that are new to the developmental tissue mechanics space, and to adopt newly developed techniques that are demonstrably better than what is commonly used in the field. That could include improved measurement tools, imaging approaches, computational models, or experimental platforms capable of quantifying forces and material properties in living embryos with higher resolution, accuracy, or throughput. The opportunity is framed to push the field forward technically and conceptually, so applications that simply apply standard methods without clear novelty or improvement would be less aligned with the intent.
Because this opportunity uses the NIH R01 mechanism, the FOA notes an expectation for sufficient preliminary data. In other words, applicants are expected to provide evidence that the hypothesis is plausible, the approach is workable, and any new technology or tool is feasible in the proposed context. This is an important distinction: while the FOA encourages new tools and superior techniques, it also signals that proposals should not be purely speculative. Applicants should be prepared to show early proof-of-concept results, validation data, or prior work that reduces risk and demonstrates readiness for a full-scale R01 project.
The FOA runs in parallel with a companion announcement, PAR-10-222, which covers a similar scientific scope but uses the R21 exploratory/developmental grant mechanism. The R01 version summarized here is intended for more mature projects with stronger supporting evidence and a clearer path to delivering substantial advances in understanding over the project period. Funding under PAR-10-221 is not guaranteed; awards are contingent on available funds and on receiving a sufficient number of scientifically meritorious applications, which is standard for NIH program announcements.
From an administrative standpoint, this is a discretionary grant opportunity under the Health category (Health, Income Security and Social Services) and is associated with multiple CFDA numbers reflecting the participating institutes and topic areas: 93.286 (technological innovations to improve human health), 93.837 (cardiovascular diseases research), 93.859 (biomedical research and research training), and 93.865 (child health and human development extramural research). There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
Eligibility is broad and includes many common NIH applicant types: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), state governments, and for-profit organizations (including small businesses). The FOA also explicitly includes several additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, regional organizations, eligible federal agencies, and non-U.S. entities (foreign organizations). This wide eligibility reflects NIH interest in drawing expertise from developmental biology, engineering, imaging, biomechanics, computational modeling, and related disciplines, regardless of institutional type or geography.
Key dates indicate the opportunity was posted on June 25, 2010, with a closing date of September 20, 2012, and an archive date of October 21, 2012, meaning it is no longer active as originally issued. The sponsoring agency is the National Institutes of Health, and the full announcement was hosted through the NIH Grants Guide. For technical issues accessing the announcement, the listed contact point was the NIH Office of Extramural Research (OER) webmaster.
FAQs: NIH PAR-10-221 - Biophysical and Biomechanical Aspects of Embryonic Development (R01)
What is PAR-10-221?
PAR-10-221 is an NIH Funding Opportunity Announcement (FOA) titled "Biophysical and Biomechanical Aspects of Embryonic Development (R01)." It invites R01 Research Project Grant applications focused on understanding embryonic development using concepts from physics and mechanics, especially how forces and material properties shape developing tissues and organs.
What is the main goal of this funding opportunity?
The main goal is to move beyond purely genetic or molecular descriptions of embryonic development by explaining how physical forces, mechanical constraints, and tissue material properties influence morphogenesis and organ formation. A strong emphasis is placed on "developmental tissue mechanics" with clear biological relevance.
What type of grant mechanism does this FOA use?
This FOA uses the NIH R01 Research Project Grant mechanism, which is intended for more mature, hypothesis-driven projects that can deliver substantial advances during the project period.
What kinds of projects are considered responsive to this FOA?
Projects are generally expected to connect measurable physical or biomechanical phenomena to developmental outcomes in vertebrate embryonic development. Examples of relevant phenomena include tissue stiffness, cell-generated forces, morphogenetic movements, fluid dynamics, mechanical signaling, and related physical constraints that shape tissues and organs.
Does the FOA focus only on normal development, or also on developmental disorders?
The FOA emphasizes both understanding normal vertebrate development and, importantly, how disruptions in mechanical processes may contribute to developmental disorders and abnormal development.
Is this FOA focused on genetics or molecular biology?
No. While biological relevance is essential, the FOA is specifically aimed at advancing understanding of embryonic development through physics and mechanics, rather than purely genetic or molecular descriptions alone.
What is meant by "developmental tissue mechanics" in this announcement?
In this context, "developmental tissue mechanics" refers to the roles of forces, material properties, and physical constraints in shaping tissues and organs as embryos develop, and how these mechanical factors influence pattern formation, organ shaping, and structural outcomes.
What level of innovation is expected?
Innovation is a major theme. Applicants are encouraged to bring in new concepts, models, and methods for developmental tissue mechanics, and to adopt newly developed techniques that are demonstrably better than commonly used approaches in the field.
What are examples of innovative approaches mentioned or implied by the FOA?
The FOA points to innovation such as improved measurement tools, advanced imaging approaches, computational models, or experimental platforms that can quantify forces and material properties in living embryos with higher resolution, accuracy, or throughput.
Are applications that use standard, widely used methods a good fit?
The FOA indicates that applications that simply apply standard methods without clear novelty or improvement are less aligned with the intent, since the opportunity is framed to push the field forward both technically and conceptually.
Does this R01 FOA expect preliminary data?
Yes. Because it uses the R01 mechanism, the FOA notes an expectation for sufficient preliminary data to support the hypothesis and demonstrate that the approach and any new tools or techniques are feasible in the proposed context.
Can the proposed work be highly exploratory or purely speculative?
The FOA encourages new tools and superior techniques, but it also signals that proposals should not be purely speculative. Applicants are expected to provide proof-of-concept results, validation data, or prior work to reduce risk and demonstrate readiness for a full-scale R01.
Which NIH institutes participate in PAR-10-221?
The participating NIH institutes listed are the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institute of General Medical Sciences (NIGMS), and the National Heart, Lung, and Blood Institute (NHLBI).
What does the range of participating institutes suggest about the scientific scope?
It indicates interest spanning fundamental developmental biology, engineering and imaging technology, basic biomedical science, and organ systems such as cardiovascular and pulmonary systems.
Is there a related or companion funding opportunity?
Yes. PAR-10-221 runs in parallel with a companion announcement, PAR-10-222, which covers a similar scientific scope but uses the R21 exploratory/developmental grant mechanism.
How is PAR-10-221 (R01) different from the companion PAR-10-222 (R21)?
Based on the FOA description, the R01 version (PAR-10-221) is intended for more mature projects with stronger supporting evidence and a clearer path to delivering substantial advances, while the R21 companion is geared toward exploratory/developmental work.
Is funding guaranteed if an application is submitted?
No. Awards are contingent on available funds and on receiving a sufficient number of scientifically meritorious applications, consistent with standard NIH program announcement conditions.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of the award.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), state governments, and for-profit organizations (including small businesses).
Are minority-serving institutions explicitly included as eligible applicants?
Yes. The FOA explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and regional organizations.
Can federal agencies apply?
Yes. The FOA includes eligible federal agencies among the explicitly listed eligible applicant categories.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) as eligible applicants.
What topic area or category is this opportunity associated with?
Administratively, it is described as a discretionary grant opportunity under the Health category (Health, Income Security and Social Services).
Which CFDA numbers are associated with this opportunity?
The FOA is associated with multiple CFDA numbers: 93.286, 93.837, 93.859, and 93.865.
What do the listed CFDA numbers correspond to (as described in the opportunity summary)?
They are described as reflecting participating institutes and topic areas, including technological innovations to improve human health (93.286), cardiovascular diseases research (93.837), biomedical research and research training (93.859), and child health and human development extramural research (93.865).
When was the FOA posted and when did it close?
The FOA was posted on June 25, 2010, and the closing date was September 20, 2012.
Is PAR-10-221 still active?
No. The archive date is October 21, 2012, which indicates the opportunity is no longer active as originally issued.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide.
Who was listed as the contact for technical issues accessing the announcement?
For technical issues accessing the announcement, the listed contact point was the NIH Office of Extramural Research (OER) webmaster.
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