Opportunity Information: Apply for PAR 13 207
Apply for PAR 13 207
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Biophysical and Biomechanical Aspects of Embryonic Development (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Apr 22, 2013 and posted on Apr 22, 2013.
- Applicants must submit their applications by Sep 17, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Special district governments For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) County governments Small businesses State governments Public housing authorities/Indian housing authorities Private institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Biophysical and Biomechanical Aspects of Embryonic Development (R01)" (Funding Opportunity Number PAR-13-207) supports hypothesis-driven research that explains embryonic development through the lens of physics and mechanics. The central goal is to move beyond purely descriptive developmental biology and generate new, critical insights into how forces, material properties, and mechanical behaviors of tissues shape vertebrate embryos. A strong emphasis is placed on work that can improve understanding of the mechanical basis of developmental abnormalities and disorders, meaning projects should connect fundamental tissue mechanics to outcomes that matter for normal development and what goes wrong when development is disrupted.
This FOA specifically calls for Research Project Grant (R01) applications, which signals a preference for mature, well-justified projects with rigorous experimental or computational plans. Consistent with standard NIH expectations for R01s, applicants are expected to include enough preliminary data to support both the key hypotheses and the feasibility of any new methods, tools, or technologies being introduced. In practical terms, proposals should not rely on untested instrumentation, speculative assays, or early-stage concepts without evidence that they can work in the proposed developmental system. The announcement also encourages investigators to bring in approaches and conceptual frameworks that are new to the developmental tissue mechanics space, particularly if they offer clear advantages over commonly used techniques in the field. That encouragement opens the door to interdisciplinary strategies, including advanced imaging, quantitative biomechanics, biophysical modeling, microfabrication, force measurement methods, and other emerging technologies, as long as they are tied to well-formed biological hypotheses.
From an administrative standpoint, this is a discretionary grant opportunity under the broad federal activity category of Health, with CFDA numbers listed as 93.837 (Cardiovascular Diseases Research), 93.859 (Biomedical Research and Research Training), and 93.865 (Child Health and Human Development Extramural Research. The award ceiling is listed as $500,000, and there is no cost sharing or matching requirement, which means applicants are not required to commit non-federal funds as a condition of the award. The opportunity was posted on April 22, 2013, with an original and current closing date of September 17, 2015, and it was archived on October 18, 2015. In other words, the listing reflects a time-limited FOA that is no longer open, but it still provides a clear picture of the type of research NIH was actively seeking under this program.
Eligibility is broad and includes many kinds of U.S. and non-U.S. institutions and organizations. Eligible applicants include public and private institutions of higher education, nonprofits (both with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, county and city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes tribal governments and tribal organizations, as well as various categories of serving institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations can participate, and foreign components (as defined by NIH policy) are allowed, which underscores NIH's willingness to support strong global expertise in embryonic biomechanics when it aligns with the program goals.
Overall, the opportunity is best understood as NIH seeking rigorous, quantitatively grounded developmental biology that treats embryogenesis as a mechanical and physical process as much as a genetic and biochemical one. Competitive applications would be expected to articulate clear hypotheses about tissue forces or material properties during vertebrate development, show why the proposed mechanical insight is biologically meaningful, and back up the plan with preliminary evidence that the measurements, models, and tools will work. The announcement link for the full text is provided at http://grants.nih.gov/grants/guide/pa-files/PAR-13-207.html, and NIH listed the Office of Extramural Research (OER) webmaster contacts for technical access or linking issues.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Biophysical and Biomechanical Aspects of Embryonic Development (R01)" and the Funding Opportunity Number (FOA) is PAR-13-207.
What type of grant mechanism does this FOA support?
This FOA calls for Research Project Grant (R01) applications, which typically indicates a preference for mature, well-justified projects with rigorous experimental and/or computational plans.
What is the main scientific focus of PAR-13-207?
The FOA supports hypothesis-driven research that explains embryonic development through the lens of physics and mechanics. It emphasizes moving beyond purely descriptive developmental biology to generate critical insights into how forces, material properties, and mechanical behaviors of tissues shape vertebrate embryos.
What is the central goal NIH describes for this program?
The central goal is to develop new, rigorous understanding of embryonic development by treating embryogenesis as a mechanical and physical process as well as a genetic and biochemical one, with particular attention to how tissue mechanics influence developmental outcomes.
Does the FOA emphasize basic science only, or also developmental disorders?
In addition to fundamental tissue mechanics, the FOA places a strong emphasis on research that can improve understanding of the mechanical basis of developmental abnormalities and disorders. Projects are expected to connect tissue mechanics to outcomes that matter for normal development and what goes wrong when development is disrupted.
What kinds of research approaches are encouraged under this opportunity?
The announcement encourages investigators to bring in approaches and conceptual frameworks that are new to developmental tissue mechanics when they offer clear advantages. Examples mentioned include advanced imaging, quantitative biomechanics, biophysical modeling, microfabrication, and force measurement methods, as well as other emerging technologies, as long as they are tied to well-formed biological hypotheses.
Is this FOA open to purely descriptive developmental biology studies?
No. The FOA explicitly aims to move beyond purely descriptive work and instead supports hypothesis-driven projects that provide mechanistic insight grounded in physics and mechanics.
What expectations are stated about preliminary data for R01 applications?
Consistent with standard NIH expectations for R01s, applicants are expected to include enough preliminary data to support the key hypotheses and to demonstrate the feasibility of any new methods, tools, or technologies introduced in the proposal.
Can an application rely on untested instruments or speculative assays?
The FOA indicates proposals should not rely on untested instrumentation, speculative assays, or early-stage concepts without evidence they can work in the proposed developmental system.
What developmental context is emphasized in this FOA?
The FOA emphasizes understanding how tissue forces and material properties shape vertebrate embryos.
What is the federal activity category for this opportunity?
The listing describes this as a discretionary grant opportunity under the broad federal activity category of Health.
Which CFDA numbers are associated with this funding opportunity?
The CFDA numbers listed are 93.837 (Cardiovascular Diseases Research), 93.859 (Biomedical Research and Research Training), and 93.865 (Child Health and Human Development Extramural Research).
What is the award ceiling listed for this opportunity?
The award ceiling is listed as $500,000.
Is cost sharing or matching required?
No. The listing states there is no cost sharing or matching requirement, meaning applicants are not required to commit non-federal funds as a condition of the award.
When was this funding opportunity posted, and what were the closing dates?
The opportunity was posted on April 22, 2013. The original and current closing date shown is September 17, 2015.
Is this FOA still open for applications?
No. The listing indicates it was archived on October 18, 2015, meaning it is no longer an open, active opportunity.
What does it mean that the FOA is archived?
Based on the information provided, archived status indicates the FOA was time-limited and is no longer accepting applications, even though it remains useful as a reference for the research themes NIH sought under the program.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and many government entities (including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal governments and tribal organizations among eligible applicants.
Are minority-serving institutions included in the eligibility list?
Yes. The FOA explicitly includes multiple categories of serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Can foreign organizations or foreign institutions apply?
Yes. The FOA states that foreign organizations and foreign institutions are eligible to apply.
Can non-U.S. components of U.S. organizations participate?
Yes. The FOA indicates non-U.S. components of U.S. organizations can participate.
Are foreign components allowed under NIH policy for this opportunity?
Yes. The FOA notes that foreign components (as defined by NIH policy) are allowed.
Where can applicants find the full FOA text?
The full announcement text is available at: http://grants.nih.gov/grants/guide/pa-files/PAR-13-207.html
Who is listed as a contact for technical access or linking issues?
NIH listed the Office of Extramural Research (OER) webmaster contacts for technical access or linking issues.
What would a competitive application likely need to articulate, based on this description?
Based on the description provided, competitive applications would be expected to: (1) articulate clear hypotheses about tissue forces or material properties during vertebrate development; (2) explain why the mechanical insight is biologically meaningful; and (3) provide preliminary evidence that proposed measurements, models, and tools will work in the chosen developmental system.
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