Opportunity Information: Apply for RFA EB 14 002

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Blood Pressure Measurement Technologies for Low Resource Settings in the US and India (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health.
  • This funding opportunity was created on Jul 10, 2014 and posted on Jul 10, 2014.
  • Applicants must submit their applications by Jan 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: City or township governments State governments County governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Apply for RFA EB 14 002

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Opportunity Summary:

The NIH funding opportunity RFA-EB-14-002, titled "Blood Pressure Measurement Technologies for Low Resource Settings in the US and India (U01)," supports research and development aimed at creating new ways to measure blood pressure that work well in underserved, low-resource environments in both countries. The focus is on practical technology innovation for hypertension, recognizing that better diagnosis and ongoing management are major unmet needs in the United States and India alike. The overarching goal is to produce blood pressure measurement approaches that can be used more easily, more flexibly, and with less burden on patients and health systems, especially where staffing, equipment, training, and reliable clinical infrastructure may be limited.

A central requirement is that the proposed technologies be noninvasive and minimally obtrusive. In other words, the program is not looking for implantable sensors or approaches that require invasive sampling, and it is also not looking for devices that are cumbersome, disruptive, or difficult to use outside of well-resourced clinical settings. The FOA emphasizes rapid and minimally intrusive measurement suitable for screening and ongoing monitoring, with an eye toward real-world use rather than purely theoretical performance. This includes designs that could support high-throughput blood pressure screening in public or community settings, where many people may need to be evaluated efficiently, as well as designs intended for individuals to use on their own. For home or regional healthcare settings, the expectation is that devices should be usable by untrained or minimally trained users, which puts a premium on simple workflows, clear instructions, and robustness to user error and challenging environments.

The award mechanism is a U01 cooperative agreement, meaning NIH expects to have substantial involvement during the project rather than operating strictly as a distant funder. Cooperative agreements commonly imply more active coordination with NIH program staff, milestones or progress expectations, and a stronger emphasis on collaboration and translation toward usable outcomes. Consistent with the binational theme, a companion announcement from the Indian government supports similar work by Indian investigators. US- and India-funded teams are expected to share results at an annual meeting, and the FOA anticipates that collaborations will develop over time as investigators compare approaches, discuss validation strategies, and align technology development with shared challenges in low-resource populations.

From a funding and logistics standpoint, NIH anticipated making about three awards under this announcement, with an estimated total funding amount of $2,000,000. The listed award ceiling is $600,000, and the opportunity does not require cost sharing or matching funds. The program falls under CFDA 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health) and is categorized in the health area. The FOA was posted on July 10, 2014, with an original and current closing date of January 7, 2015, and an archive date of February 7, 2015, reflecting that it was a time-limited solicitation rather than an ongoing open submission program.

Eligibility is broad across many US organization types, including state, county, and city governments; public and private institutions of higher education; nonprofits with and without 501(c)(3) status; independent school districts; special district governments; tribal governments and tribally controlled institutions; public housing authorities; and for-profit organizations (other than small businesses), alongside small businesses as well. The eligibility notes also explicitly include categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and eligible federal agencies. At the same time, foreign institutions and other non-US entities are not eligible to apply directly, and non-domestic components of US organizations are not eligible; however, foreign components as defined under NIH policy are allowed, which typically means certain project elements may be carried out abroad under specific compliance conditions, even though the applicant organization must be eligible and primarily domestic.

In practical terms, this FOA is aimed at pushing blood pressure measurement beyond conventional clinic-centered models by encouraging devices and measurement strategies that can function in community screening environments and in homes, especially for people who may not have consistent access to healthcare professionals or well-equipped facilities. The intended payoff is improved hypertension detection and management in underserved communities, with shared learning between US and Indian investigators and regular cross-country exchange to accelerate progress and ensure the technologies fit real constraints on cost, usability, and deployment.

Frequently Asked Questions (FAQs)

What is the funding opportunity RFA-EB-14-002 about?

RFA-EB-14-002 is an NIH funding opportunity titled "Blood Pressure Measurement Technologies for Low Resource Settings in the US and India (U01)." It supports research and development to create new, practical ways to measure blood pressure that work well in underserved, low-resource environments in both the United States and India.

What is the main goal of this FOA?

The overarching goal is to produce blood pressure measurement approaches that are easier to use, more flexible, and less burdensome for patients and health systems, particularly in settings where staffing, equipment, training, and reliable clinical infrastructure may be limited.

What health problem is this program trying to address?

The program focuses on hypertension, specifically the unmet needs around better diagnosis and ongoing management. It recognizes that improved blood pressure measurement can help support screening and long-term monitoring in underserved communities.

What kinds of technologies does the FOA emphasize?

The FOA emphasizes practical technology innovation for blood pressure measurement, with an emphasis on real-world usability in low-resource settings rather than purely theoretical or clinic-only performance.

Are invasive or implantable approaches allowed?

No. A central requirement is that proposed technologies must be noninvasive and minimally obtrusive. The program is not looking for implantable sensors or approaches requiring invasive sampling.

What does "minimally obtrusive" mean in this context?

It means the measurement approach should not be cumbersome, disruptive, or difficult to use outside well-resourced clinical settings. The FOA highlights rapid and minimally intrusive measurement suitable for screening and ongoing monitoring.

Does the FOA prioritize screening, monitoring, or both?

Both. The FOA calls for technologies suitable for screening (including high-throughput screening in public or community settings) and for ongoing monitoring (including designs intended for individuals to use on their own).

What is meant by high-throughput blood pressure screening?

High-throughput screening refers to situations where many people need to be evaluated efficiently, such as public or community settings, and the technology should support rapid, practical measurement workflows.

Are home-use or community-use devices expected?

Yes. The FOA explicitly discusses community screening environments and home or regional healthcare settings, with the expectation that devices can work where clinical infrastructure may be limited.

Do devices need to be usable by untrained users?

For home or regional healthcare settings, the expectation is that devices should be usable by untrained or minimally trained users. This places a premium on simple workflows, clear instructions, and robustness to user error and challenging environments.

What is the award mechanism for this opportunity?

The award mechanism is a U01 cooperative agreement.

What does a U01 cooperative agreement imply for NIH involvement?

A cooperative agreement means NIH expects to have substantial involvement during the project rather than acting only as a distant funder. This commonly includes more active coordination with NIH program staff, and may include milestones or progress expectations and a strong emphasis on collaboration and translation toward usable outcomes.

Is this opportunity specifically tied to work in both the US and India?

Yes. The opportunity is explicitly framed around low-resource settings in both the United States and India, and it includes expectations for cross-country exchange and shared learning.

Is there a related or companion announcement for Indian investigators?

Yes. The FOA notes that a companion announcement from the Indian government supports similar work by Indian investigators.

Are US- and India-funded teams expected to interact?

Yes. US- and India-funded teams are expected to share results at an annual meeting, and the FOA anticipates collaborations will develop over time as investigators compare approaches, discuss validation strategies, and align technology development with shared challenges in low-resource populations.

How many awards did NIH anticipate making?

NIH anticipated making about three awards under this announcement.

What was the estimated total funding amount?

The estimated total funding amount listed is $2,000,000.

What is the award ceiling?

The listed award ceiling is $600,000.

Is cost sharing or matching required?

No. The opportunity does not require cost sharing or matching funds.

What CFDA number is associated with this program?

The program falls under CFDA 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health).

What is the program area/category?

It is categorized in the health area.

When was the FOA posted?

The FOA was posted on July 10, 2014.

What were the closing and archive dates?

The original and current closing date is January 7, 2015, and the archive date is February 7, 2015. This indicates it was a time-limited solicitation rather than an ongoing open submission program.

Who is eligible to apply?

Eligibility is broad across many US organization types, including state, county, and city governments; public and private institutions of higher education; nonprofits with and without 501(c)(3) status; independent school districts; special district governments; tribal governments and tribally controlled institutions; public housing authorities; for-profit organizations (other than small businesses); and small businesses.

Are specific institution types explicitly included?

Yes. The eligibility notes explicitly include categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and eligible federal agencies.

Can foreign institutions apply directly?

No. Foreign institutions and other non-US entities are not eligible to apply directly.

Are non-domestic components of US organizations eligible?

No. Non-domestic components of US organizations are not eligible.

Are any foreign components allowed at all?

Yes. Foreign components, as defined under NIH policy, are allowed. This typically means certain project elements may be carried out abroad under specific compliance conditions, even though the applicant organization must be eligible and primarily domestic.

What kinds of settings are considered "low resource" for this FOA?

Based on the FOA description, low-resource settings include environments where staffing, equipment, training, and reliable clinical infrastructure may be limited, such as community screening settings and home or regional healthcare settings.

What is the practical impact the FOA is trying to achieve?

The intended payoff is improved hypertension detection and management in underserved communities by enabling blood pressure measurement strategies that fit real constraints on cost, usability, and deployment, supported by shared learning between US and Indian investigators.

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