Opportunity Information: Apply for RFA HL 17 015
Apply for RFA HL 17 015
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Bold New Bioengineering Methods and Approaches for Heart, Lung, Blood and Sleep Disorders and Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840,.
- This funding opportunity was created on Jun 13, 2016 and posted on Jun 13, 2016.
- Applicants must submit their applications by May 10, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
Bold New Bioengineering Methods and Approaches for Heart, Lung, Blood and Sleep Disorders and Diseases (R21) (RFA-HL-17-015) is a National Institutes of Health funding opportunity, administered through HHS/NIH (in practice, this aligns with the mission space of the National Heart, Lung, and Blood Institute), aimed at sparking early, high-impact bioengineering research that could change how heart, lung, blood, and sleep disorders are understood, detected, monitored, or treated. The FOA is built around proof-of-concept work, meaning the emphasis is on demonstrating feasibility and generating convincing preliminary evidence that a new engineering-driven method or approach can work, rather than delivering a fully mature product or definitive clinical trial outcomes. It explicitly welcomes projects across the spectrum of basic, translational, and clinical research as long as the proposed work advances bioengineering approaches relevant to these disease areas.
The grant mechanism is an R21, which is typically used by NIH to support exploratory and developmental projects that are novel, potentially transformative, and somewhat higher risk than standard incremental research. In that spirit, this FOA encourages applicants to propose bold methods and enabling technologies, including new tools, platforms, devices, measurement approaches, computational strategies, or engineered systems that can open up previously difficult questions or clinical needs in cardiopulmonary, hematologic, and sleep health. Projects may focus on the creation of new bioengineering techniques, the adaptation of emerging engineering capabilities into these biomedical domains, or the early demonstration that an approach can function in relevant laboratory, animal, or human settings. The key theme is advancement of bioengineering approaches rather than routine hypothesis testing using established methods.
From a funding perspective, the opportunity is categorized as a discretionary grant program, with an award ceiling listed as $150,000. Applicants should treat that ceiling as a practical upper bound for the proposed budget under this announcement and plan a tightly scoped set of aims that can credibly deliver a proof-of-concept outcome within the resource limits. The FOA listing does not specify the number of expected awards in the provided source snippet, but the R21 format generally implies a competitive selection focused on innovation, significance, and feasibility of the proposed concept.
Eligibility is broad and includes a wide range of domestic organization types. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those specific nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed under the FOA’s additional eligibility text. This broad eligibility aligns with the engineering and translational nature of the program, where academic labs, hospitals, nonprofit research centers, and commercial entities may all be positioned to contribute new methods or prototype technologies.
The activity category is Health, and the opportunity is associated with multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840), reflecting NIH’s cataloging across related institute and program lines that touch heart and vascular disease, lung disease, blood disorders, sleep research, and related translational efforts. The opportunity was posted and created on June 13, 2016, and the closing date for applications was May 10, 2019, indicating it is a past-dated announcement in the form provided. Even so, the described purpose remains useful as a reference point for the kind of work NIH seeks under exploratory bioengineering-focused R21 initiatives in these disease areas.
In practical terms, a strong application under this FOA would typically be expected to clearly identify an unmet need or bottleneck in heart, lung, blood, or sleep disorder research or care, then present an engineering-based approach that is distinctly new or used in a novel way, and finally lay out a realistic plan to demonstrate feasibility. Because the FOA emphasizes proof-of-concept, proposed milestones often center on showing that a prototype can generate interpretable signals, that a new assay can reliably measure a target, that a computational model can predict clinically meaningful outcomes, or that a new interface or device concept can operate safely and effectively in a relevant test environment. The overall aim is to de-risk an innovative bioengineering concept enough that it can later be scaled into larger validation studies, product development, or more definitive clinical research.
Frequently Asked Questions (FAQs)
What is the funding opportunity?
It is an NIH funding opportunity titled Bold New Bioengineering Methods and Approaches for Heart, Lung, Blood and Sleep Disorders and Diseases (R21) with FOA number RFA-HL-17-015. It is administered through HHS/NIH and aligns in practice with the National Heart, Lung, and Blood Institute mission space.
What is the main goal of this FOA?
The goal is to spark early, high-impact bioengineering research that could change how heart, lung, blood, and sleep disorders are understood, detected, monitored, or treated. The emphasis is on bold, enabling engineering-driven methods and approaches rather than incremental studies.
What does "proof-of-concept" mean for this announcement?
Proof-of-concept means the project should focus on demonstrating feasibility and generating convincing preliminary evidence that a new engineering method or approach can work. The FOA is not centered on delivering a fully mature product or producing definitive clinical trial outcomes.
What grant mechanism is used and what does it imply?
This FOA uses the NIH R21 mechanism, which typically supports exploratory and developmental projects that are novel, potentially transformative, and somewhat higher risk than standard incremental research. The expectation is a tightly scoped, innovative project designed to de-risk a new concept.
What research areas does this opportunity cover?
It covers bioengineering methods and approaches relevant to heart, lung, blood, and sleep disorders and diseases. Projects can address how these conditions are understood, detected, monitored, or treated, as long as the work advances a bioengineering approach.
Is the FOA limited to basic research, or can it include translational and clinical work?
It explicitly welcomes projects across the spectrum of basic, translational, and clinical research, as long as the proposed work advances bioengineering approaches relevant to the covered disease areas.
What types of projects are encouraged?
The FOA encourages bold methods and enabling technologies, including new tools, platforms, devices, measurement approaches, computational strategies, or engineered systems. Projects may involve creating new techniques, adapting emerging engineering capabilities to these biomedical domains, or demonstrating early functionality in relevant settings.
What kinds of technologies or approaches are specifically mentioned as examples?
Examples described include new tools, platforms, devices, measurement approaches, computational strategies, and engineered systems that help address previously difficult questions or clinical needs in cardiopulmonary, hematologic, and sleep health.
What is the key theme reviewers would likely look for based on the description?
The key theme is the advancement of bioengineering approaches rather than routine hypothesis testing using established methods. The project should be distinctly new or use an existing engineering approach in a novel way for these disease areas.
What is the award ceiling mentioned for this opportunity?
The opportunity is described as a discretionary grant program with an award ceiling listed as $150,000. Applicants are advised to treat this as a practical upper bound for the proposed budget and to scope aims accordingly.
Does the provided information state how many awards will be made?
No. The provided snippet does not specify the expected number of awards. It does note that the R21 format generally implies a competitive selection focused on innovation, significance, and feasibility.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types, including governments, higher education institutions, tribal entities, nonprofits, and for-profit organizations (including small businesses), as described in the FOA summary.
Which government entities are eligible?
Eligible government applicants include state, county, and local governments, as well as special district governments.
Are educational institutions eligible?
Yes. Eligible applicants include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education.
Are tribal organizations eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and other Native American tribal organizations.
Are housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed among eligible applicants.
Are nonprofits eligible, and does 501(c)(3) status matter?
Yes. Eligible applicants include nonprofits with or without 501(c)(3) status (excluding institutions of higher education within those specific nonprofit categories, as stated in the provided eligibility description).
Are for-profit organizations eligible?
Yes. Eligible applicants include for-profit organizations other than small businesses as well as small businesses.
What is the activity category for this opportunity?
The activity category is Health.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.233, 93.837, 93.838, 93.839, and 93.840.
What do the multiple CFDA numbers indicate?
They reflect NIH cataloging across related institute and program lines that touch heart and vascular disease, lung disease, blood disorders, sleep research, and related translational efforts.
When was the opportunity posted and when did it close?
The opportunity was posted and created on June 13, 2016, and the closing date for applications was May 10, 2019.
Is this an active funding opportunity based on the dates provided?
Based on the provided dates, it appears to be past-dated in the form shown (closing date May 10, 2019).
What kind of project plan would typically fit the "tightly scoped" R21 expectation described?
A fit-for-purpose plan would identify an unmet need or bottleneck in heart, lung, blood, or sleep research or care, propose a distinctly new engineering-based approach, and lay out a realistic set of steps to demonstrate feasibility within the resource limits and proof-of-concept focus.
What are examples of proof-of-concept milestones mentioned or implied in the description?
Milestones often center on demonstrating that a prototype can generate interpretable signals, that a new assay can reliably measure a target, that a computational model can predict clinically meaningful outcomes, or that a new interface or device concept can operate safely and effectively in a relevant test environment.
What settings can be used to demonstrate feasibility?
The description indicates feasibility can be demonstrated in relevant laboratory, animal, or human settings, depending on the approach.
What is the intended next step after a successful proof-of-concept under this FOA?
The aim is to de-risk an innovative bioengineering concept enough that it can later be scaled into larger validation studies, product development, or more definitive clinical research.
Browse more opportunities from the same agency: HHS-NIH11
Browse more opportunities from the same category: Health
Next opportunity: Notice of Intent
Previous opportunity: Mechanisms for speciess responses to climate change: are there biological response thresholds?
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA HL 17 015
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA HL 17 015) also looked into and applied for these:
| Funding Opportunity |
|---|
| Limited Competition: NIDCR Supplements to NCATS CTSA Programs for Scholars Pursing Dental, Oral and Craniofacial Clinical and Translational Research Career Development (Admin Supp) Apply for RFA DE 17 008 Funding Number: RFA DE 17 008 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Guidance for Supplemental CDC/NCCDPHP/BRFSS Funding Opportunity Announcement (FOA) CDC-RFA-DP15-15130201SUPPPPHF16 Behavioral Risk Factor Surveillance System (BRFSS) Apply for CDC RFA DP15 15130201SUPPPPHF16 Funding Number: CDC RFA DP15 15130201SUPPPPHF16 Agency: HHS-CDC-NCCDPHP Category: Health Funding Amount: $160,000 |
| Limited Competition: Administrative Supplements to Enhance Network Capacity: Collaborative Opportunities for the CTSA Program (Admin Supp) Apply for PA 16 328 Funding Number: PA 16 328 Agency: HHS-NIH11 Category: Health Funding Amount: $300,000 |
| Embassy Conakry Ebola-Related Projects Apply for CKY PAS FY16 002 Funding Number: CKY PAS FY16 002 Agency: DOS-AF Category: Health Funding Amount: $10,000 |
| National HIV Surveillance System (NHSS) Apply for CDC RFA PS13 130205CONT17 Funding Number: CDC RFA PS13 130205CONT17 Agency: HHS-CDC-NCHHSTP Category: Health Funding Amount: Case Dependent |
| Science of Behavior Change: Use-inspired Basic Research to Optimize Behavior Change Interventions and Outcomes (Admin Supp) Apply for PA 16 334 Funding Number: PA 16 334 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| National Accessibility Technical Assistance and Support Apply for P16AS00252 Funding Number: P16AS00252 Agency: DOI-NPS Category: Health Funding Amount: $100,000 |
| Strengthening of Public Health Programs to address Communicable and Non-Communicable Diseases in the Republic of Kenya including the Presidents Emergency Plan for AIDS Relief (PEPFAR). Apply for CDC RFA GH16 1703 Funding Number: CDC RFA GH16 1703 Agency: HHS-CDC-CGH Category: Health Funding Amount: Case Dependent |
| Service Area Competition Apply for HRSA 17 050 Funding Number: HRSA 17 050 Agency: HHS-HRSA Category: Health Funding Amount: Case Dependent |
| NHLBI Pilot Program to Provide Regulatory Support to SBIR/STTR Awardees Developing Medical Devices (Diagnostics and Therapeutics) (Admin Supp) Apply for PA 16 335 Funding Number: PA 16 335 Agency: HHS-NIH11 Category: Health Funding Amount: $5,000 |
| Urban Indian Education and Research Organization Cooperative Agreement Program Apply for HHS 2016 IHS UIHP3 0001 Funding Number: HHS 2016 IHS UIHP3 0001 Agency: HHS-IHS Category: Health Funding Amount: $800,000 |
| Planning Grant for NINDS Morris K. Udall Parkinson's Disease Research Center Without Walls (R34) Apply for RFA NS 16 024 Funding Number: RFA NS 16 024 Agency: HHS-NIH11 Category: Health Funding Amount: $150,000 |
| Native American Independent Living Demonstration Project Apply for HHS 2016 ACL AOD IL 0184 Funding Number: HHS 2016 ACL AOD IL 0184 Agency: HHS-ACL Category: Health Funding Amount: $250,000 |
| Tuberculosis regional Training and Medical Consultation Centers,National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Apply for CDC RFA PS13 130404CONT17 Funding Number: CDC RFA PS13 130404CONT17 Agency: Department of Health and Human Services, Centers for Disease Control - NCHHSTP Category: Health Funding Amount: Case Dependent |
| Pediatric Audiology Competitive Supplement to Leadership Education in Neurodevelopmental and Related Disabilities (LEND) Apply for HRSA 16 190 Funding Number: HRSA 16 190 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $80,000 |
| Service Area Competition Apply for HRSA 17 051 Funding Number: HRSA 17 051 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Office of Clinical and Preventive Services: National HIV Program; HIV/AIDS Prevention and Engagement in Care Apply for HHS 2016 IHS OCPS HIV 0001 Funding Number: HHS 2016 IHS OCPS HIV 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Health Funding Amount: $100,000 |
| Division of Behavioral Health, Office of Clinical and Preventive Services, Methamphetamine and Suicide Prevention Initiative - Generation Indigenous (Gen-I) Initiative Support - New Apply for HHS 2016 IHS MSPI 0001 Funding Number: HHS 2016 IHS MSPI 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Health Funding Amount: $300,000 |
| A National Coalition to Enhance STD/HIV Prevention through Promotion of a Holistic Approach to Health and Wellness Apply for CDC RFA PS11 11120501SUPP16 Funding Number: CDC RFA PS11 11120501SUPP16 Agency: Department of Health and Human Services, Centers for Disease Control - NCHHSTP Category: Health Funding Amount: $250,000 |
| Service Area Competition Apply for HRSA 17 052 Funding Number: HRSA 17 052 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA HL 17 015", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.