Opportunity Information: Apply for W81XWH 16 BCRP BREAKTHROUGHFL34
Apply for W81XWH 16 BCRP BREAKTHROUGHFL34
- The DOD-AMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Breast Cancer Breakthrough Award Levels 3 and 4" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 01, 2016 and posted on Mar 01, 2016.
- Applicants must submit their applications by Aug 11, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Breast Cancer Breakthrough Award Levels 3 and 4 is a Department of Defense Breast Cancer Research Program (BCRP) funding opportunity designed to back ambitious, high-impact research that can realistically push the field forward in a meaningful way. The core idea is that projects supported through this mechanism should have a strong chance of leading to true breakthroughs in breast cancer rather than producing only incremental progress. Applicants are expected to clearly explain why their approach could change the trajectory of research or care and to lay out a credible pathway to clinical impact for people who have breast cancer or who are at risk for developing it, even if the work itself is not immediately clinical.
A defining feature of this opportunity is its focus on impact that is both substantial and well-justified. The program is explicitly looking for research that can accelerate progress toward ending breast cancer, with outcomes that could be near-term or longer-term, but that must be significant. In practical terms, this means proposals should connect the science to real-world consequences: how the work could influence diagnosis, risk prediction, treatment decisions, prevention strategies, or outcomes for patients. Reviewers are looking for applicants to articulate not just what will be discovered, but how those discoveries could translate into clinically relevant steps.
The announcement offers two scope-based funding levels, Level 3 and Level 4, and stresses that investigators should choose a level based on the scale and maturity of the proposed research rather than simply matching a budget number. Level 3 is aimed at advanced translational studies that are close enough to the clinic to support near-term clinical investigation. Small-scale clinical trials are allowed at this level, which signals that the program is open to work that is already sufficiently developed to be tested in patient-oriented settings, as long as the trial scope is modest and fits the translational focus.
Level 4 is positioned as the highest-impact category: large-scale projects intended to transform and potentially revolutionize the clinical management and/or prevention of breast cancer, with near-term clinical impact expected. This level is meant for major efforts that are big enough to change practice or prevention paradigms, and it comes with an expectation that the Principal Investigator has demonstrated experience successfully leading large, complex projects. A notable requirement for Level 4 is that an invited oral presentation is part of the application review process, meaning teams should be prepared not only to submit strong written materials but also to defend and communicate the project effectively in a live review setting.
Collaboration is strongly encouraged through a Partnering PI Option. Under this structure, two Principal Investigators participate as an Initiating PI and a Partnering PI, and each receives a separate award. While their submission requirements are not identical, the expectation is that both PIs will materially shape the project, including key pieces like the Project Narrative and the Statement of Work. The program is clear that the partnership should be substantive: each PI should bring distinct expertise or capabilities that make the combined team more effective than separate, parallel efforts. New collaborations are welcomed but not mandatory, and applicants must explain why the partnership is necessary and how it strengthens the ability to answer the research question. To prevent superficial teaming, the announcement discourages investigators from serving as a Partnering PI on multiple applications unless each one addresses clearly different research questions. It also clarifies that pairing a mentor with their current postdoctoral fellow or junior investigator does not fit the intent of this option, reinforcing that the program is seeking peer-level, complementary collaborations rather than training-oriented arrangements.
From an administrative standpoint, this opportunity is listed as Funding Opportunity Number W81XWH-16-BCRP-BREAKTHROUGHFL34 and is administered by DOD-AMRAA. It is categorized as discretionary funding and uses grant and cooperative agreement instruments, supporting science and technology research and development under CFDA 12.420. Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement. The posting date and creation date are both March 1, 2016, with an application closing date of August 11, 2016. The listing indicates an expected number of awards of five, and the award ceiling is not specified in the provided summary data.
FAQs: Breast Cancer Breakthrough Award Levels 3 and 4 (DOD BCRP)
What is the Breast Cancer Breakthrough Award Levels 3 and 4 opportunity?
This is a Department of Defense (DOD) Breast Cancer Research Program (BCRP) funding opportunity intended to support ambitious, high-impact breast cancer research with a strong chance of producing true breakthroughs rather than incremental advances.
What is the main goal of this funding mechanism?
The goal is to accelerate meaningful progress toward ending breast cancer by supporting projects that can substantially advance the field and credibly lead to clinical impact for people who have breast cancer or who are at risk of developing it.
What kind of impact does the program expect proposals to demonstrate?
Proposals are expected to justify substantial impact and connect the proposed science to real-world outcomes, such as influence on diagnosis, risk prediction, treatment decisions, prevention strategies, or patient outcomes. Applicants should explain not only what will be discovered, but how those discoveries could translate into clinically relevant steps.
Does the proposed work need to be immediately clinical?
No. The work does not have to be immediately clinical, but applicants are expected to lay out a credible pathway to clinical impact, even if the project itself is not a clinical study at the time of award.
What are the two funding levels offered under this announcement?
The announcement offers two scope-based categories: Level 3 and Level 4. Applicants are expected to choose a level based on the scale and maturity of the proposed research rather than choosing based only on budget size.
How is Level 3 described?
Level 3 is aimed at advanced translational studies that are close enough to the clinic to support near-term clinical investigation. The program indicates that small-scale clinical trials are allowed at this level, provided they fit the translational focus and modest trial scope.
Are clinical trials allowed in Level 3 applications?
Yes. The summary explicitly notes that small-scale clinical trials are allowed under Level 3, reflecting the expectation that Level 3 projects can be sufficiently developed for patient-oriented testing on a modest scale.
How is Level 4 described?
Level 4 is positioned as the highest-impact category for large-scale projects intended to transform and potentially revolutionize the clinical management and/or prevention of breast cancer. Near-term clinical impact is expected for Level 4 projects.
What leadership expectations are associated with Level 4?
Level 4 includes an expectation that the Principal Investigator (PI) has demonstrated experience successfully leading large, complex projects, reflecting the major scale and intended field-changing impact of this level.
Is there an oral presentation requirement for Level 4?
Yes. A notable Level 4 requirement is that an invited oral presentation is part of the application review process. Teams should be prepared to communicate and defend the project in a live review setting in addition to submitting written materials.
What is the Partnering PI Option?
The opportunity strongly encourages collaboration through a Partnering PI Option. Under this option, two PIs participate as an Initiating PI and a Partnering PI, and each PI receives a separate award.
Do both PIs have to contribute meaningfully under the Partnering PI Option?
Yes. The partnership is expected to be substantive. Both PIs are expected to materially shape the project, including key components such as the Project Narrative and the Statement of Work, even if their submission requirements are not identical.
What is the program looking for in a partnering arrangement?
The program expects each PI to bring distinct expertise or capabilities that make the combined team stronger than separate, parallel efforts. Applicants must explain why the partnership is necessary and how it strengthens the ability to answer the research question.
Are new collaborations required?
No. New collaborations are welcomed but not mandatory, based on the information provided in the opportunity summary.
Can someone serve as a Partnering PI on multiple applications?
The announcement discourages investigators from serving as a Partnering PI on multiple applications unless each application addresses clearly different research questions. This is intended to prevent superficial or duplicative teaming.
Does pairing a mentor with a current postdoctoral fellow or junior investigator fit the Partnering PI intent?
No. The summary clarifies that pairing a mentor with their current postdoctoral fellow or junior investigator does not fit the intent of the Partnering PI Option. The program is seeking peer-level, complementary collaborations rather than training-oriented arrangements.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number listed is W81XWH-16-BCRP-BREAKTHROUGHFL34.
Who administers this funding opportunity?
The opportunity is administered by DOD-AMRAA.
What type of funding is this categorized as?
It is categorized as discretionary funding and uses grant and cooperative agreement instruments, supporting science and technology research and development.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement.
When was the opportunity posted, and what is the application deadline?
The posting date and creation date are both March 1, 2016. The application closing date is August 11, 2016.
How many awards are expected?
The listing indicates an expected number of five awards.
Is the award ceiling specified in the provided summary?
No. The award ceiling is not specified in the summary information provided.
What should applicants emphasize in their proposal narrative based on this summary?
Applicants should emphasize why the approach could change the trajectory of breast cancer research or care, provide a well-justified case for substantial impact, and present a credible pathway to clinical relevance (near-term or longer-term). Proposals should clearly connect scientific aims to potential consequences for diagnosis, risk prediction, treatment, prevention, or patient outcomes.
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| Breast Cancer Breakthrough Award Levels 1 and 2 Apply for W81XWH 16 BCRP BREAKTHROUGHFL12 Funding Number: W81XWH 16 BCRP BREAKTHROUGHFL12 Agency: DOD-AMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Breast Cancer Distinguished Investigator Award Apply for W81XWH 16 BCRP DIA Funding Number: W81XWH 16 BCRP DIA Agency: DOD-AMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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