Opportunity Information: Apply for PA 11 317
Apply for PA 11 317
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Building a Genetic and Genomic Knowledge Base in Dental, Oral, and Craniofacial Diseases and Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Aug 19, 2011 and posted on Aug 19, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Native American tribal governments (Federally recognized) Special district governments Private institutions of higher education Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Building a Genetic and Genomic Knowledge Base in Dental, Oral, and Craniofacial Diseases and Disorders (R01)" (Funding Opportunity Number PA 11-317) was designed to support R01 research projects that expand what is known about the genetic and genomic contributors to dental, oral, and craniofacial conditions. The central focus is on diseases and disorders that appear to be heritable, meaning family and population data suggest genetics plays a meaningful role, but where the specific genes, variants, pathways, and biological mechanisms are still not well understood. In practical terms, the program aims to move these conditions from "we suspect there is a genetic basis" to "we can point to specific genomic regions and variants and explain how they influence disease risk or disease biology."
Research supported under this announcement is meant to do two closely related things. First, it encourages studies that identify promising areas of the genome linked to disease risk, such as locating genomic regions associated with susceptibility or protection. This can include a variety of human genetics and genomics approaches intended to find signals worth pursuing. Second, and just as importantly, it supports work that characterizes and clarifies what those genetic variants actually do, with an emphasis on functional understanding. That functional emphasis means projects are expected to go beyond listing associations by investigating how a variant changes gene expression, protein function, cellular behavior, tissue development, immune responses, or other biological processes that plausibly connect the genome to the clinical phenotype. The long-range objective is that these discoveries will feed directly into better ways to diagnose, treat, and prevent dental, oral, and craniofacial diseases, rather than stopping at purely descriptive genetics.
The opportunity falls under the NIH health research mission and is associated with CFDA 93.121 (Oral Diseases and Disorders Research). It used the R01 grant mechanism, which typically supports substantial, investigator-driven research programs, and it did not require cost sharing or matching funds. The announcement was posted on August 19, 2011, with an original and final closing date of September 7, 2014, and it was archived on October 8, 2014. While the funding window has closed, the description is still useful as a snapshot of NIH priorities in building foundational genomic knowledge for oral and craniofacial conditions and as a model for what NIH often looks for in genetics-to-mechanism proposals.
Eligibility was broad and included many types of domestic and international institutions and organizations. Eligible applicants included public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), small businesses and other for-profit organizations, state and local governments (including counties, cities, townships, special districts), independent school districts, public housing authorities/Indian housing authorities, and multiple categories of tribal governments and tribal organizations. The announcement explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. Foreign institutions were also eligible, along with non-U.S. components of U.S. organizations, and foreign components were allowed as defined by NIH policy. This wide eligibility reflects an intent to attract strong genetics and genomics research teams wherever they are based, including collaborations that bring specialized populations, datasets, clinical cohorts, or laboratory capabilities to the work.
For further details, the full announcement was hosted through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-317.html, and NIH Office of Extramural Research provided support contacts (FBOWebmaster@OD.NIH.GOV) for access or linking issues.
FAQs: NIH "Building a Genetic and Genomic Knowledge Base in Dental, Oral, and Craniofacial Diseases and Disorders (R01)" (PA-11-317)
What is this NIH funding opportunity?
This opportunity is the NIH program announcement titled "Building a Genetic and Genomic Knowledge Base in Dental, Oral, and Craniofacial Diseases and Disorders (R01)," Funding Opportunity Number PA 11-317. It was designed to support R01 research projects that expand knowledge about genetic and genomic contributors to dental, oral, and craniofacial diseases and disorders.
What is the main goal of PA 11-317?
The central goal is to move certain dental, oral, and craniofacial conditions from a general understanding that they are likely heritable to a more specific, evidence-based understanding of which genes, variants, pathways, and biological mechanisms are involved. In other words, the program emphasizes progress from suspicion of genetic influence to pinpointing specific genomic factors and explaining how they influence disease risk or disease biology.
What kinds of conditions were the focus of this program?
The focus was on diseases and disorders in the dental, oral, and craniofacial space that appear to be heritable based on family and population data, but where the specific genetic contributors and mechanisms were still not well understood.
What does "heritable" mean in the context of this announcement?
In this context, "heritable" refers to conditions where family and population data suggest genetics plays a meaningful role in risk or disease presentation, even if the specific genes or variants have not yet been clearly identified.
What types of research activities were encouraged?
The announcement emphasized two closely related types of work: (1) identifying promising genomic regions or signals linked to disease susceptibility or protection, and (2) characterizing what implicated genetic variants actually do, with a focus on functional understanding that plausibly connects genomic variation to clinical phenotypes.
Is this opportunity only about finding genetic associations?
No. While identifying genomic regions or variants associated with disease risk was encouraged, the opportunity placed clear emphasis on functional characterization. Projects were expected to go beyond listing associations by investigating biological mechanisms.
What does "functional understanding" mean for projects under this program?
Functional understanding means investigating how a genetic variant influences biological processes relevant to disease. Examples mentioned include effects on gene expression, protein function, cellular behavior, tissue development, immune responses, or other mechanisms that could connect genotype to the clinical phenotype.
How does NIH expect this research to be used in the long run?
The long-range objective is that genetic and genomic discoveries supported by this program would feed into better approaches for diagnosing, treating, and preventing dental, oral, and craniofacial diseases and disorders, rather than remaining purely descriptive.
What grant mechanism did this program use?
This funding opportunity used the NIH R01 grant mechanism, which typically supports substantial, investigator-driven research programs.
Was cost sharing or matching required?
No. The announcement stated that it did not require cost sharing or matching funds.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.121, "Oral Diseases and Disorders Research."
When was PA 11-317 posted?
The announcement was posted on August 19, 2011.
What were the closing dates for submissions?
The announcement listed an original and final closing date of September 7, 2014.
Is this funding opportunity still open?
No. The submission window has closed. The announcement was archived on October 8, 2014.
Why might PA 11-317 still be useful to read if it is archived?
Even though it is closed, the description provides a snapshot of NIH priorities around building foundational genomic knowledge for dental, oral, and craniofacial conditions, and it serves as a model of what NIH often looks for in genetics-to-mechanism proposals.
Who was eligible to apply?
Eligibility was broad and included many domestic and international institutions and organizations. Eligible applicants included public and private institutions of higher education; nonprofits (both 501(c)(3) and non-501(c)(3)); small businesses and other for-profit organizations; and various government entities.
Were for-profit organizations allowed to apply?
Yes. The eligibility list included small businesses and other for-profit organizations.
Were state and local government entities eligible?
Yes. The announcement included state and local governments, including counties, cities, townships, and special districts.
Were independent school districts eligible?
Yes. Independent school districts were explicitly included in the eligibility list.
Were public housing authorities eligible?
Yes. The eligibility list included public housing authorities and Indian housing authorities.
Were Tribal governments and Tribal organizations eligible?
Yes. Multiple categories of Tribal governments and Tribal organizations were included as eligible applicants.
Were certain minority-serving institutions explicitly included?
Yes. The announcement explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were explicitly included.
Were U.S. territories or possessions eligible to apply?
Yes. The eligibility list included U.S. territories or possessions.
Were foreign institutions eligible?
Yes. Foreign institutions were eligible, and non-U.S. components of U.S. organizations were also eligible. Foreign components were allowed as defined by NIH policy.
Does the announcement encourage collaboration across institutions or countries?
The broad eligibility and explicit inclusion of foreign institutions and foreign components indicate the opportunity was intended to attract strong genetics and genomics research teams wherever they are based, including collaborations that contribute specialized populations, datasets, clinical cohorts, or laboratory capabilities.
Where can the full announcement be found?
The full announcement was hosted through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-11-317.html
Who can be contacted for help accessing the announcement or for linking issues?
NIH Office of Extramural Research provided support contacts for access or linking issues at FBOWebmaster@OD.NIH.GOV.
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