Building Effective Health Information Systems under the Presidents Emergency Plan for AIDS Relief (PEPFAR) | Apply Online

Opportunity Summary:

Building Effective Health Information Systems under the President's Emergency Plan for AIDS Relief (PEPFAR) is a CDC cooperative agreement funding opportunity focused on strengthening the digital and governance backbone that supports HIV program delivery and monitoring. As PEPFAR-supported testing and treatment programs have expanded over many years, the volume and complexity of patient and program data have grown to a level that paper-based systems cannot handle reliably. The opportunity is built around the idea that well-designed health information systems are now essential to sustaining ART programs, tracking outcomes for people living with HIV, and enabling timely, evidence-based decisions by ministries of health and implementing partners.

The core purpose of the announcement is to support the design, development, implementation, and practical use of health information systems (HIS) that PEPFAR programs rely on. This includes electronic medical records (EMRs), laboratory information systems (LIS), human resource information systems (HRIS), district health information systems such as DHIS platforms, and electronic case-based surveillance systems, along with other related digital tools that help implement, track, and evaluate PEPFAR activities. Rather than funding a single software product, the FOA emphasizes building an effective overall information ecosystem that can manage patient-level and program-level data across multiple services and sites.

A central theme is standardization and interoperability. As more countries and partners implement EMRs, LIS, pharmacy systems, HR tools, and reporting platforms, problems often arise when systems cannot talk to each other or use consistent definitions. This FOA highlights the need to standardize functional and technical requirements, develop architectures that enable data exchange and sharing, and support interoperability across platforms. It also calls out common challenges in large HIV programs, such as linking records across facilities and services and de-duplicating patient identities so that data represent real individuals and real care histories rather than fragmented or double-counted records.

The opportunity also prioritizes data quality, completeness, and trustworthiness, because the value of digital systems depends on the accuracy and consistency of the information they contain. Alongside quality improvements, the FOA places strong emphasis on data security, privacy, and confidentiality safeguards. Given the sensitivity of HIV-related information, awardees are expected to help strengthen protections that reduce the risk of inappropriate access, disclosure, or misuse while still enabling legitimate clinical and public health use of data.

While innovative technical solutions are mentioned as part of the approach, the FOA makes it clear that most impact is expected to come from strengthening the enabling environment and local capacity. That includes better strategic planning and governance for national HIS, developing in-country human capacity to implement and maintain systems over time, and supporting ongoing evaluation of HIS implementations. The evaluation focus is practical: identifying effective informatics practices, documenting efficiencies gained, assessing health impacts, and improving sustainability and country ownership. Cost effectiveness is also explicitly noted, signaling that funders want evidence that investments in HIS produce measurable value and can be maintained realistically within country constraints.

Administratively, this is a discretionary CDC funding opportunity using a cooperative agreement mechanism, which typically involves substantial involvement from the CDC in collaboration, technical input, and oversight compared with a standard grant. The funding opportunity number is CDC RFA GH15-1535, categorized under Health, with CFDA 93.067 (Global AIDS). The FOA anticipated three awards, with an award ceiling of $1,600,000; no cost sharing or matching was required. Key dates included a posted date of September 15, 2014, and an original/current closing date of October 20, 2014, with an archive date of November 19, 2014.

Eligibility is broad and spans both government and non-government entities. Eligible applicants include national ministries of health; state, local, and territorial governments and their bona fide agents (including U.S. territories and freely associated states listed in the announcement); American Indian/Alaska Native tribal governments; and political subdivisions of states (with state consultation). Non-government applicants can include tribally designated organizations, Alaska Native health corporations, tribal epidemiology centers, urban Indian health organizations, nonprofits (with or without 501(c)(3) status, excluding institutions of higher education), research institutions conducting non-research activities, colleges and universities, community-based and faith-based organizations, hospitals, for-profit organizations (other than small businesses), and small/minority/women-owned businesses, among others.

Overall, the grant opportunity targets the practical foundations needed for modern HIV programs: systems that can scale with patient volumes, exchange information across clinics and labs, protect confidentiality, and generate reliable data for decision-making. At the same time, it pushes beyond software deployment to the harder, long-term work of governance, workforce development, and continuous evaluation so that health information systems become sustainable national assets rather than short-term project tools. For technical issues accessing the full announcement, the CDC Procurement and Grants Office Technical Information Management Section is listed as the contact (pgotim@cdc.gov, 770-488-2700).

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