Opportunity Information: Apply for PAR 16 250
Apply for PAR 16 250
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Building Evidence: Effective Palliative/End of Life Care Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361,.
- This funding opportunity was created on May 10, 2016 and posted on May 10, 2016.
- Applicants must submit their applications by Jun 10, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
Building Evidence: Effective Palliative/End of Life Care Interventions (R01) (PAR-16-250) is a National Institutes of Health (NIH) research grant opportunity focused on strengthening the evidence base for palliative and end-of-life care. The main purpose is to fund rigorous studies that test palliative/end-of-life care (EOLPC) interventions and models of care, with a clear emphasis on outcomes that matter to individuals with serious, advanced illness and to their families. Rather than supporting descriptive work alone, the announcement is geared toward trials and other strong evaluation designs that can determine whether specific approaches work, for whom they work, and under what conditions they can be delivered effectively in real-world settings.
A central theme of the opportunity is the need for well-tested, patient- and family-centered care strategies across the full range of serious illness, including in both pediatric and adult populations. The FOA highlights an urgent gap in tested interventions that are responsive to racial, ethnic, and cultural diversity. In practice, that means applicants are expected to design and evaluate interventions or care models that account for differences in beliefs, communication norms, family roles in decision-making, trust in the health system, and structural barriers that can shape access to and quality of palliative care. Projects that explicitly address inequities in end-of-life and palliative care experiences and outcomes are especially aligned with the stated priorities.
The research emphasis is on testing efficacy and effectiveness of EOLPC interventions/models of care. Efficacy testing generally asks whether an intervention works under more controlled or ideal conditions, while effectiveness focuses on performance in routine clinical or community settings. The FOA signals interest in both types of testing, which supports a pipeline from well-controlled trials to pragmatic evaluations that can inform implementation and broader adoption. Interventions could include clinical practices, care team configurations, communication and decision-support approaches, symptom management strategies, caregiver support programs, care coordination methods, or other service delivery models intended to improve quality of life, goal-concordant care, family outcomes, and related endpoints.
This is an NIH R01 mechanism, meaning it is intended for substantial research projects that require a solid scientific premise, a clear analytic plan, and enough scope to generate definitive findings. The funding instrument type is a grant, and the activity category is listed under education and health, reflecting the public health and clinical systems focus of palliative care research. The announcement was posted May 10, 2016, with an original and current closing date of June 10, 2019, indicating the window during which applications were accepted under this specific posting.
Eligibility is broad and includes many types of organizations that can conduct or support research. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The listing also includes an “others” category with additional eligibility details referenced in the full FOA. The sponsoring agency is within the U.S. Department of Health and Human Services, specifically NIH (listed as HHS-NIH11). The CFDA numbers associated with the opportunity are 93.361 (and the listing also shows 93.361 again as part of the CFDA field).
Overall, the opportunity is aimed at moving palliative and end-of-life care toward more evidence-based, equitable practice by funding studies that can credibly demonstrate which interventions and models improve patient and family outcomes. The strongest alignment comes from proposals that are trial-ready, outcomes-driven, attentive to cultural and racial/ethnic diversity, and designed to produce findings that can realistically influence care delivery for people living with serious, advanced illness.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Building Evidence: Effective Palliative/End of Life Care Interventions (R01), funding opportunity number PAR-16-250.
Which agency is sponsoring this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH), within the U.S. Department of Health and Human Services (HHS). The listing identifies the sponsor as HHS-NIH11.
What is the primary purpose of this FOA?
The main purpose is to strengthen the evidence base for palliative and end-of-life care by funding rigorous studies that test palliative/end-of-life care (EOLPC) interventions and models of care, with an emphasis on outcomes that matter to individuals with serious, advanced illness and to their families.
What kinds of studies does the FOA prioritize?
The FOA prioritizes studies with strong evaluation designs, such as trials and other rigorous approaches that can determine whether specific interventions or models of care work, for whom they work, and under what conditions they can be delivered effectively in real-world settings. It is not aimed at supporting descriptive work alone.
Is this funding intended for descriptive or observational work only?
No. Based on the information provided, the announcement is geared toward testing interventions and models of care using rigorous designs, rather than funding descriptive work alone.
What does “palliative/end-of-life care interventions and models of care” mean in this context?
In this FOA, it refers to strategies and approaches intended to improve care for people with serious, advanced illness and their families. Examples mentioned include clinical practices, care team configurations, communication and decision-support approaches, symptom management strategies, caregiver support programs, care coordination methods, and other service delivery models.
What patient populations are included?
The FOA highlights the need for patient- and family-centered care strategies across the full range of serious illness, including both pediatric and adult populations.
What outcomes does NIH want applicants to focus on?
The FOA emphasizes outcomes that matter to patients with serious, advanced illness and to their families. Examples referenced include quality of life, goal-concordant care, family outcomes, and related endpoints.
What is the difference between efficacy and effectiveness research in this FOA?
As described, efficacy testing asks whether an intervention works under more controlled or ideal conditions, while effectiveness testing examines how an intervention performs in routine clinical or community settings. The FOA signals interest in both.
Does the FOA support research along a pipeline from controlled trials to real-world evaluations?
Yes. The information provided indicates NIH interest in both efficacy and effectiveness testing, supporting a pipeline from more controlled studies to pragmatic evaluations that can inform implementation and broader adoption in real-world settings.
How important is patient- and family-centered design in applications?
It is a central theme. The FOA explicitly calls for well-tested, patient- and family-centered care strategies and emphasizes outcomes that matter to patients and families.
Does the FOA address health equity, race, ethnicity, and culture?
Yes. The FOA highlights an urgent gap in tested interventions responsive to racial, ethnic, and cultural diversity, and it expects interventions or care models to account for differences in beliefs, communication norms, family roles in decision-making, trust in the health system, and structural barriers that can affect access and quality.
Are projects that address inequities in palliative and end-of-life care especially encouraged?
Yes. The information provided states that projects explicitly addressing inequities in end-of-life and palliative care experiences and outcomes are especially aligned with the priorities described.
What types of interventions are considered relevant for this FOA?
Interventions may include (as examples listed): clinical practices; care team configurations; communication and decision-support approaches; symptom management strategies; caregiver support programs; care coordination methods; or other service delivery models intended to improve key patient and family outcomes.
What NIH grant mechanism is being used?
This opportunity uses the NIH R01 mechanism.
What does an R01 mechanism imply about project scope?
Based on the description provided, an R01 is intended for substantial research projects that require a solid scientific premise, a clear analytic plan, and enough scope to generate definitive findings.
What is the funding instrument type?
The funding instrument type is a grant.
What is the activity category listed for this opportunity?
The activity category is listed under education and health, reflecting the public health and clinical systems focus of palliative care research.
When was this FOA posted?
The announcement was posted on May 10, 2016.
What was the closing date for this specific posting?
The original and current closing date shown is June 10, 2019, indicating the window during which applications were accepted under this specific posting.
Who is eligible to apply?
Eligibility is broad and includes many organization types that can conduct or support research. Eligible applicants listed include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other tribal organizations
- Public housing authorities / Indian housing authorities
- Nonprofit organizations with 501(c)(3) status
- Nonprofit organizations without 501(c)(3) status
- For-profit organizations other than small businesses
- Small businesses
- Others (with additional eligibility details referenced in the full FOA)
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses and also separately lists small businesses.
Are tribal entities eligible to apply?
Yes. The eligibility list includes federally recognized Native American tribal governments and other tribal organizations.
Are universities and colleges eligible to apply?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are local and state government entities eligible to apply?
Yes. The eligibility list includes state, county, city/township, and special district governments, as well as independent school districts.
Are housing authorities eligible to apply?
Yes. The eligibility list includes public housing authorities and Indian housing authorities.
What CFDA number is associated with this opportunity?
The CFDA number shown is 93.361 (it is also listed again in the CFDA field).
What is the overall goal of the FOA in the palliative care field?
The overall goal is to move palliative and end-of-life care toward more evidence-based and equitable practice by funding studies that can credibly demonstrate which interventions and models improve patient and family outcomes.
What kinds of applications appear most aligned with the FOA’s priorities?
Based on the description provided, the strongest alignment comes from proposals that are trial-ready, outcomes-driven, attentive to cultural and racial/ethnic diversity, and designed to produce findings that can realistically influence care delivery for people living with serious, advanced illness.
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