Opportunity Information: Apply for PA 14 347
Apply for PA 14 347
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Building Genetics and Genomic Knowledge about Dental, Oral, and Craniofacial Diseases and Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Sep 22, 2014 and posted on Sep 22, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts County governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities State governments City or township governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Building Genetics and Genomic Knowledge about Dental, Oral, and Craniofacial Diseases and Disorders (R01) (Funding Opportunity Number PA 14-347) is a National Institutes of Health (NIH) discretionary grant opportunity designed to expand what is known about the genetic and genomic drivers of dental, oral, and craniofacial conditions. The core focus is on diseases and disorders where research or clinical evidence suggests heritability, but where the specific genes, variants, biological pathways, and mechanisms are still poorly defined. In practical terms, the program is meant to move the field from "we know genetics matters here" to "we can pinpoint the genomic regions and variants involved, understand what they do, and use that knowledge to improve patient care."
The FOA encourages R01 research projects that identify promising regions of the genome associated with disease risk and then dig deeper to determine how specific genetic variants contribute to disease. This includes studies aimed at finding risk-associated loci as well as functional work to characterize how those variants influence gene expression, protein function, cellular behavior, tissue development, immune responses, or other biological processes relevant to oral and craniofacial health. The emphasis is on generating actionable genetic and genomic knowledge that can ultimately support better diagnostic tools, more targeted therapies, and stronger prevention strategies, rather than stopping at purely descriptive genetic associations.
From a scope standpoint, the announcement is broad within the dental, oral, and craniofacial domain and is aligned with CFDA 93.121 (Oral Diseases and Disorders Research). It supports health-related research projects under the NIH R01 mechanism, which typically funds mature, hypothesis-driven programs of research of meaningful size and duration. While the short description highlights genome-region identification and functional elucidation of variants in humans, the spirit of the FOA is translational in the sense that it prioritizes studies that can connect genetic findings to biological insight and, eventually, clinical impact. The long-term objective is to help enable effective diagnostics (such as risk stratification or biomarker development), therapeutics (such as target identification and validation), and preventive approaches (such as identifying high-risk individuals or modifiable pathways).
Eligibility is notably expansive. A wide range of U.S. organizations can apply, including public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including entities other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. The FOA also explicitly includes many mission-driven and community-focused institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with tribal governments (federally recognized and other than federally recognized), faith-based or community-based organizations, and eligible federal agencies. International participation is allowed as well: non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are permitted.
Administrative details in the source indicate there is no cost sharing or matching requirement, making the project budget primarily driven by NIH allowability rules and the proposed scientific plan rather than a requirement for applicant-side financial contribution. The FOA was posted on September 22, 2014, with an original and current closing date listed as January 7, 2018, and an archive date of February 7, 2018, meaning the opportunity is now archived rather than active for new submissions under that specific announcement. For the full official announcement and policy-specific details, the provided link points to the NIH Grants Guide page for PA-14-347 (http://grants.nih.gov/grants/guide/pa-files/PA-14-347.html). Support contacts referenced in the source are the NIH Office of Extramural Research (OER) webmaster addresses for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
1) What is the full name and funding opportunity number for this grant?
The opportunity is titled Building Genetics and Genomic Knowledge about Dental, Oral, and Craniofacial Diseases and Disorders (R01). The Funding Opportunity Number is PA-14-347.
2) Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
3) What type of grant mechanism does this program use?
The program uses the NIH R01 mechanism, which is commonly used to support mature, hypothesis-driven research projects of meaningful size and duration.
4) What is the main purpose of PA-14-347?
The purpose is to expand what is known about the genetic and genomic drivers of dental, oral, and craniofacial diseases and disorders, especially for conditions where evidence suggests heritability but the specific genes, variants, pathways, and mechanisms are still poorly defined.
5) What kinds of conditions are most relevant to this FOA?
The FOA focuses on dental, oral, and craniofacial diseases and disorders where research or clinical evidence suggests a heritable component, but where the underlying genetic variants and biological mechanisms are not yet well understood.
6) What does the FOA mean by moving beyond "descriptive genetic associations"?
It means the FOA prioritizes projects that do more than identify statistical associations. It encourages studies that connect genetic findings to biological function and generate actionable genomic knowledge that can support future diagnostics, therapeutics, or prevention strategies.
7) What types of research activities does the FOA encourage?
The FOA encourages R01 projects that (1) identify promising genomic regions associated with disease risk and then (2) perform deeper work to determine how specific variants contribute to disease, including functional characterization.
8) Does the FOA support studies to find risk-associated loci?
Yes. The opportunity explicitly includes studies aimed at finding risk-associated loci for dental, oral, and craniofacial conditions.
9) Does the FOA support functional studies of genetic variants?
Yes. In addition to identifying regions or loci, the FOA encourages functional work to characterize how variants influence biology relevant to oral and craniofacial health.
10) What kinds of functional effects are in scope?
The FOA describes functional studies that may examine how variants influence things like gene expression, protein function, cellular behavior, tissue development, immune responses, or other biological processes tied to dental, oral, and craniofacial health.
11) Is this opportunity considered translational?
Based on the description provided, the FOA is translational in spirit because it prioritizes connecting genetic findings to biological insight with an eye toward eventual clinical impact, rather than stopping at association results.
12) What long-term outcomes is the FOA trying to enable?
The long-term objective is to help enable:
- Diagnostics (for example, risk stratification or biomarker development)
- Therapeutics (for example, identifying and validating targets)
- Prevention strategies (for example, identifying high-risk individuals or modifiable pathways)
13) What CFDA program is associated with this opportunity?
The FOA is aligned with CFDA 93.121 (Oral Diseases and Disorders Research).
14) Is cost sharing or matching required?
No. The administrative details indicate there is no cost sharing or matching requirement.
15) Who is eligible to apply?
Eligibility is broad and includes many U.S. organization types, including:
- Public and private institutions of higher education
- Nonprofits (with and without 501(c)(3) status)
- For-profit organizations (including entities other than small businesses)
- Small businesses
- State, county, city/township governments, and special district governments
- Independent school districts
- Public housing authorities / Indian housing authorities
- Eligible federal agencies
16) Are minority-serving or mission-driven institutions explicitly included?
Yes. The FOA explicitly includes institution types such as HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs, among others.
17) Can tribal governments apply?
Yes. The FOA includes tribal governments, including those that are federally recognized and those other than federally recognized.
18) Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicants.
19) Are international (non-U.S.) organizations eligible?
Yes. International participation is allowed. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are permitted.
20) When was this FOA posted?
The FOA was posted on September 22, 2014.
21) What were the listed closing date and archive date?
The original and current closing date listed is January 7, 2018, and the archive date is February 7, 2018.
22) Is this funding opportunity currently active?
No. Based on the information provided, the FOA is archived, meaning it is not active for new submissions under that specific announcement.
23) Where can applicants find the official NIH Grants Guide announcement?
The official announcement is available on the NIH Grants Guide page for PA-14-347 here: http://grants.nih.gov/grants/guide/pa-files/PA-14-347.html
24) Who is listed as a support contact for access or linking issues?
The support contact referenced is the NIH Office of Extramural Research (OER) webmaster email for access or linking issues: FBOWebmaster@OD.NIH.GOV.
25) How is the project budget determined if there is no matching requirement?
The description indicates that, without a cost sharing requirement, the project budget is primarily driven by NIH allowability rules and the proposed scientific plan, rather than a required applicant financial contribution.
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