Calcium Oxalate Stone Diseases (R01) | Apply Online

Opportunity Summary:

The Calcium Oxalate Stone Diseases (R01) opportunity (Funding Opportunity Number PA-07-051) is a National Institutes of Health (NIH) grant announcement led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), specifically through its Division of Kidney, Urologic and Hematologic Diseases. It targets research on calcium oxalate stone disease with a clear emphasis on the genetics and heritability of oxalate regulation, along with the development of new treatments. The overall intent is to draw more investigators into this space and accelerate progress by encouraging studies that can clarify why some individuals are predisposed to oxalate-related stone formation and how that risk can be reduced or managed more effectively.

A central feature of the announcement is its focus on innovative and forward-looking research approaches. The FOA invites not only full research projects but also pilot and feasibility studies, recognizing that the field benefits from early-stage work that tests new methods, generates preliminary data, and explores emerging hypotheses. The scientific scope spans the practical clinical pipeline as well: diagnosis, treatment, and prevention. In other words, projects can be oriented toward basic genetic mechanisms of oxalate handling, translational work that connects genetic findings to clinical risk, or intervention-focused studies aimed at improving therapies and preventive strategies for oxalate stone diseases.

This FOA uses the NIH Research Project Grant (R01) mechanism, which is typically suited for substantial, hypothesis-driven projects with a defined research plan and measurable outcomes. The announcement also notes that it runs in parallel with a separate but scientifically identical opportunity that uses the R21 Exploratory/Developmental mechanism (PA-06-152). That parallel structure matters because it gives applicants two pathways depending on the maturity of their idea: an R01 for more developed projects ready for a full-scale effort, and an R21 for earlier exploratory concepts that may need initial proof-of-concept data.

NIDDK flagged this initiative as a high priority area and indicated that it is supported by a set-aside of NIDDK Special Emphasis funds. Practically, this signals that the institute is actively trying to stimulate activity in this topic area and may have reserved funds to ensure strong applications in this space can be supported, consistent with the referenced NIDDK notice about special emphasis funding. While it does not guarantee funding, it does communicate institute-level prioritization and encouragement for investigators working on these questions.

From an eligibility standpoint, the FOA is open to a broad range of domestic applicants across government, academic, nonprofit, and private-sector organizations. Eligible applicants include state, county, city/township, and special district governments; tribal governments and other tribal organizations; public and private institutions of higher education; nonprofit organizations both with and without 501(c)(3) status; public housing authorities/Indian housing authorities; small businesses; and other organizations as described in the full announcement. Faith-based and community-based organizations are explicitly allowed to apply, and eligible federal government agencies may also apply. A key restriction is that foreign institutions are not eligible to apply under this announcement.

Administratively, the opportunity is categorized as a discretionary grant in the health area and does not require cost sharing or matching. It was posted on November 21, 2006, with multiple receipt dates and a series of closing dates listed in the announcement record (with a current closing date shown as September 7, 2009, and an archive date of October 8, 2009). Applicants were directed to the full FOA text for the specific receipt dates, application instructions, and any additional requirements. The full announcement was hosted on the NIH grants guide website at http://grants.nih.gov/grants/guide/pa-files/PA-07-051.html, with NIH Office of Extramural Research (OER) webmaster contact information provided for access or linking issues.

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Previous opportunity: Ancillary Studies of Kidney Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases (R01)

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