Opportunity Information: Apply for PA 09 144

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Cancer Surveillance Using Health Claims based Data System (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes 93.399 Cancer Control.
  • This funding opportunity was created on Apr 3, 2009 and posted on Apr 3, 2009.
  • Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $275,000.00 in funding.
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Cancer Surveillance Using Health Claims based Data System (R21) opportunity (Funding Opportunity Number PA-09-144) is a National Cancer Institute (NCI) funding announcement from the National Institutes of Health that supports exploratory and developmental research using health insurance claims data to improve cancer surveillance. The central idea is to help researchers test, refine, and validate methods for using claims-based data systems to understand what happens to cancer patients in real-world care settings. Rather than focusing on traditional cancer registry reporting alone, this program highlights claims data as a potentially powerful source for tracking patterns of care, measuring quality of care, assessing outcomes, and identifying health disparities across the full cancer care continuum, from diagnosis and treatment through follow-up and survivorship.

This FOA is specifically designed for the NIH R21 mechanism, which is typically used for early-stage, high-potential projects that are still in the exploratory phase. The emphasis is on methodological work and feasibility-building: projects might examine how accurate claims data are for identifying cancer diagnoses, staging proxies, treatments, complications, recurrence signals, survivorship care, or end-of-life care patterns, and what analytic approaches are needed to make claims data more reliable for surveillance purposes. The announcement also makes room for pilot analyses that generate preliminary evidence to support a larger subsequent proposal, such as an R01, which fits with the role of R21 awards as a bridge between an idea and a fully powered research program.

The scientific scope of this R21 runs in parallel with two related opportunities covering the same topic area but using different NIH mechanisms: an R01 (PA-09-145) for larger, more mature research projects, and an R03 (PA-09-143) for smaller, short-term studies. In practice, that means applicants could pursue the same general scientific theme (claims-based cancer surveillance) but choose the mechanism that best matches the stage, scale, and resource needs of their proposed work.

From an administrative and funding standpoint, this is a discretionary grant opportunity with no cost-sharing or matching requirement. The award ceiling listed for this FOA is $275,000. It is categorized under health and education-related funding activity areas and is associated with CFDA numbers 93.226 (Research on Healthcare Costs, Quality and Outcomes) and 93.399 (Cancer Control). The announcement was posted and created on April 3, 2009, and it originally closed on May 7, 2012, with an archive date of June 7, 2012, meaning it is no longer an active solicitation but remains important as a reference point for the type of research NCI has encouraged in this space.

Eligibility is broad and spans many organization types, reflecting NIH-wide norms. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit types), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state, county, city/township, special district governments, and independent school districts. The eligibility language also explicitly includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, U.S. territories or possessions, and regional organizations. Additional categories called out include historically underrepresented and mission-focused institutions and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, and even non-U.S. (foreign) entities. Federal agencies are also listed among eligible applicants, which is less commonly emphasized in many non-NIH programs but can be relevant for certain research groups.

Overall, the opportunity supports early, method-focused cancer surveillance research that leverages health claims data to answer practical questions about cancer care delivery, outcomes, quality, and disparities, while also tackling the core challenge of whether and how claims data can be used validly for surveillance purposes. The full archived announcement is referenced at http://grants.nih.gov/grants/guide/pa-files/PA-09-144.html, with NIH Office of Extramural Research (OER) webmaster contacts provided for access or linking issues.

Frequently Asked Questions (FAQs)

What is the funding opportunity?

This opportunity is the Cancer Surveillance Using Health Claims based Data System (R21) funding announcement from the National Cancer Institute (NCI) at the National Institutes of Health (NIH). The Funding Opportunity Number (FOA) is PA-09-144.

What is the main purpose of PA-09-144?

The central purpose is to support exploratory and developmental research that uses health insurance claims data to improve cancer surveillance. The focus is on testing, refining, and validating methods for using claims-based data systems to better understand what happens to cancer patients in real-world care settings.

What type of research does this FOA emphasize?

This FOA emphasizes methodological and feasibility-building research. It is designed for early-stage, high-potential projects that are still exploratory, with an emphasis on developing and validating analytic approaches that make claims data more reliable for cancer surveillance.

Why does this opportunity focus on health insurance claims data instead of only cancer registries?

Rather than relying on traditional cancer registry reporting alone, the FOA highlights claims data as a potentially powerful source for tracking patterns of care, measuring quality of care, assessing outcomes, and identifying health disparities across the cancer care continuum (from diagnosis and treatment through follow-up and survivorship).

What kinds of questions or topics might an R21 project address under this FOA?

Projects may examine how well claims data can be used to identify or infer cancer-relevant information and care events, including (as examples mentioned in the opportunity) diagnoses, staging proxies, treatments, complications, recurrence signals, survivorship care, and end-of-life care patterns, along with the analytic methods needed to improve validity for surveillance.

Is this opportunity intended for fully developed, large-scale research programs?

No. This FOA uses the NIH R21 mechanism, which is typically intended for exploratory and developmental work. It supports projects that may not yet be fully powered or mature, and it places strong emphasis on methods development, feasibility, and early evidence generation.

Can this R21 be used to generate preliminary results for a future proposal?

Yes. The FOA explicitly allows room for pilot analyses that generate preliminary evidence to support a larger subsequent proposal, such as an R01. This aligns with the common use of R21 awards as a bridge between an initial concept and a more fully developed research program.

What NIH grant mechanism does this FOA use?

This announcement is specifically designed for the NIH R21 mechanism.

Are there related funding opportunities on the same topic?

Yes. The scientific scope is described as running in parallel with two related opportunities covering the same topic area but using different NIH mechanisms: an R01 (PA-09-145) for larger, more mature research projects, and an R03 (PA-09-143) for smaller, short-term studies.

How should an applicant choose between the R21, R01, and R03 for claims-based cancer surveillance research?

Based on the information provided, the topic area is similar across the three opportunities (claims-based cancer surveillance), but the mechanisms differ in stage and scale. Applicants would generally align the mechanism with how exploratory versus mature the project is and the level of resources needed.

What is the maximum award amount listed for PA-09-144?

The award ceiling listed for this FOA is $275,000.

Is cost-sharing or matching required?

No. This is described as a discretionary grant opportunity with no cost-sharing or matching requirement.

What are the funding activity areas associated with this opportunity?

The opportunity is categorized under health and education-related funding activity areas.

What CFDA numbers are associated with this FOA?

The opportunity is associated with CFDA 93.226 (Research on Healthcare Costs, Quality and Outcomes) and 93.399 (Cancer Control).

When was this announcement posted, and is it still active?

The announcement was posted and created on April 3, 2009. It originally closed on May 7, 2012, with an archive date of June 7, 2012. That means it is no longer an active solicitation, but it remains available as an archived reference.

Where can the archived FOA be found?

The archived announcement is referenced at: http://grants.nih.gov/grants/guide/pa-files/PA-09-144.html

Who is the sponsoring agency for PA-09-144?

The sponsoring institute is the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).

What types of organizations are eligible to apply?

Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and other nonprofit types); for-profit organizations (including small businesses and other for-profits); and many government entities (state, county, city/township, special district governments, and independent school districts).

Are tribal entities eligible to apply?

Yes. The eligibility language explicitly includes tribal governments and tribal organizations.

Are U.S. territories or regional organizations eligible?

Yes. The eligibility language includes U.S. territories or possessions and regional organizations.

Are mission-focused or underrepresented institutions specifically included?

Yes. The eligibility categories called out include Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities (TCCUs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly included among eligible applicants.

Are non-U.S. (foreign) entities eligible to apply?

Yes. Non-U.S. (foreign) entities are explicitly included in the eligibility language.

Are federal agencies eligible applicants?

Yes. Federal agencies are listed among eligible applicants in the eligibility description provided.

What real-world cancer surveillance uses are highlighted for claims-based data systems?

The opportunity highlights the use of claims data to track patterns of care, measure quality of care, assess outcomes, and identify health disparities across the cancer care continuum, including diagnosis, treatment, follow-up, and survivorship.

What is the core challenge this FOA is trying to address?

The opportunity emphasizes tackling the fundamental question of whether and how claims data can be used validly for cancer surveillance, including what methods are needed to test accuracy and improve reliability.

Who should be contacted for website access or linking issues related to the FOA page?

The archived announcement notes that NIH Office of Extramural Research (OER) webmaster contacts are provided for access or linking issues.

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