Career Development Program in Omics of Lung Diseases (K12) | Apply Online

Opportunity Summary:

The Career Development Program in Omics of Lung Diseases (K12) is a National Institutes of Health (NIH) training and career development grant opportunity designed to build a structured program that helps early-career investigators become independent researchers in the rapidly expanding area of omics-driven lung disease research. The core purpose is not simply to fund individual projects, but to support an organized, multidisciplinary career development environment where new MD and PhD (or equivalent) investigators gain the practical skills, mentorship, and research experience needed to use modern high-dimensional biological data to answer clinically meaningful questions in pulmonary medicine. At a high level, the program is aimed at accelerating the pipeline of scientists who can move smoothly between computational, molecular, and clinical domains and who can translate large-scale biological measurements into insights that improve understanding of lung disease and support personalized medicine.

Scientifically, the opportunity emphasizes "pan-omics" and integrated approaches, meaning applicants are expected to train scholars to work across multiple layers of biological information rather than relying on a single data type. This includes genomics and other omics modalities, along with analytical strategies that can integrate these measurements to uncover molecular mechanisms of disease. The target outcomes include a deeper understanding of the genomic and molecular bases of lung diseases, an ability to study disease heterogeneity (why patients with the same diagnosis can have very different molecular profiles and outcomes), identification of key regulatory networks (the pathways and interacting biological systems that drive disease processes), and discovery or validation of biomarkers that are relevant for diagnosis, prognosis, or treatment response. The longer-term vision is to push the field toward better mechanistic understanding of lung disease pathobiology and to support future applications of lung disease personalized medicine.

Because the work sits at the intersection of computation and clinical medicine, the announcement makes clear that a successful program needs broad expertise. The training environment is expected to include strong bioinformatics and computational biology capacity, experience working with data from large patient cohorts, and the ability to leverage electronic medical records (EMRs) or related clinical data resources. In addition, the program should provide training in integrative genomics and systems-level analysis approaches, since the point is to connect molecular data to biological processes and clinical phenotypes. At the same time, scholars should have exposure to, or direct involvement in, clinical research and pulmonary medicine so their work remains tied to real lung disease questions, patient populations, and clinically interpretable endpoints.

The mechanism is a K12 institutional career development award, which typically supports an institution-led program that recruits and mentors multiple early-stage scholars under a defined curriculum and mentorship structure. The emphasis here is on building a multidisciplinary training experience, and the announcement explicitly encourages institutions to propose multiple Program Directors/Principal Investigators (PDs/PIs). That detail signals NIH's expectation that leadership may need to be shared across complementary domains (for example, pulmonary/clinical expertise paired with computational genomics leadership) to create a credible program that can train scholars across the full omics-to-clinic pipeline.

In terms of administration and eligibility, the funding opportunity number is RFA-HL-13-023, and it falls under the NIH’s lung diseases research area (CFDA 93.838). It is a discretionary grant program with no cost sharing or matching requirement, which generally lowers barriers for eligible institutions to apply. Eligible applicants include a wide range of U.S.-based organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both with and without 501(c)(3) status, excluding institutions of higher education where specified), Native American tribal governments and tribal organizations, and a variety of designated serving institutions and community-based organizations (including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities, and U.S. territories or possessions). Foreign institutions are not eligible, and foreign components are not allowed under NIH policy for this announcement, including non-U.S. components of U.S. organizations.

Key dates show that the opportunity was posted on July 26, 2012, with an original and current closing date of October 26, 2012, and it was archived on November 26, 2012. While that means this specific announcement is historical, the summary remains useful as a description of NIH’s goals for building institutional training capacity in omics and lung disease research. For full details, NIH provided an additional information link to the official RFA on the NIH grants site, and a contact route through the NIH Office of Extramural Research (OER) webmaster is included for access or technical issues.

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