Opportunity Information: Apply for RFA AA 10 005
Apply for RFA AA 10 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Case Ascertainment to Estimate the U.S. Prevalence of Fetal Alcohol Spectrum Disorders in Young Children (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Oct 23, 2009 and posted on Oct 23, 2009.
- Applicants must submit their applications by Dec 22, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,400,000.00 in funding.
- Eligible applicants include: Private institutions of higher education City or township governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses State governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This grant opportunity, RFA AA 10 005, was issued by the National Institutes of Health through the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to fund studies that can produce credible, reproducible estimates of how common fetal alcohol spectrum disorders (FASD) are among young children in the United States. The core goal is to calculate prevalence rates within clearly defined geographic areas, such as specific counties or cities, in ways that reflect the general population living in those areas. The announcement emphasizes that the work should cover the broader FASD continuum, specifically including fetal alcohol syndrome (FAS), partial FAS, and alcohol-related neurodevelopmental disorders, rather than focusing on a single diagnosis.
The projects are expected to use active case ascertainment, meaning teams do not rely only on existing diagnoses or passive reporting systems. Instead, they actively seek, identify, and clinically evaluate potential cases within the target population to avoid undercounting. NIAAA frames this effort as part of the Collaboration on FASD Prevalence (CoFASP), described as the final group of awardees supported under this request for applications. The intent is to support multidisciplinary research teams capable of conducting population-based field work, coordinating clinical evaluations, and producing estimates that are not just local snapshots but are reasonable and generalizable for comparable U.S. communities.
A central requirement is the development and/or use of a standardized diagnostic system to evaluate clinical characteristics of FASD among affected children. In practice, that means applicants need a clear, consistent, and defensible approach for determining who meets criteria for FASD-related diagnoses, so that estimates can be compared across sites and repeated over time. The program’s emphasis on standardized diagnostics also signals that NIAAA is looking for methodological rigor: well-defined case definitions, consistent assessment procedures, and clinical evaluation processes that can support prevalence calculations that policymakers and public health leaders can trust.
Funding is offered through a cooperative agreement mechanism (U01), which generally indicates substantial scientific or programmatic involvement by the federal agency during the project period compared to a typical research project grant. The total estimated funding available is about $2,000,000, with an anticipated one to three awards depending on funds and application quality. The project period can be up to five years, and proposed direct costs are expected to fall roughly between $500,000 and $1,400,000 per year across the five-year period, reflecting the scale and logistical demands of active case ascertainment and standardized clinical assessment.
The opportunity is categorized as discretionary funding and sits within the health funding activity area, associated with CFDA number 93.273 (Alcohol Research Programs). It does not require cost sharing or matching. Eligibility is broad and includes many types of U.S. institutions and governmental entities, such as public and private institutions of higher education, state and local governments (including county, city/township, special district), independent school districts, and a wide range of nonprofit and for-profit organizations. The eligibility language also explicitly includes various community-focused and capacity-building institution types and entities, such as faith-based or community-based organizations, historically Black colleges and universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, tribal governments and tribal organizations, and U.S. territories or possessions. The announcement also lists non-U.S. entities and regional organizations among eligible applicants, signaling openness to certain external partners where appropriate, although the research focus is clearly on U.S. geographic areas and U.S. prevalence estimation.
Key timing details in the source information show the funding announcement was posted and created on October 23, 2009, with an original and current closing date of December 22, 2009, and an archive date of January 22, 2010. The full announcement was hosted on the NIH grants site, and NIH provided standard technical contact information for access and linking issues through the NIH Office of Extramural Research webmaster.
Frequently Asked Questions (FAQs)
What is the purpose of RFA AA 10 005?
The purpose of RFA AA 10 005 is to fund studies that produce credible, reproducible estimates of how common fetal alcohol spectrum disorders (FASD) are among young children in the United States. The emphasis is on generating prevalence rates for clearly defined geographic areas (for example, specific counties or cities) in ways that reflect the general population living in those areas.
Which federal agency and institute issued this opportunity?
This opportunity was issued by the National Institutes of Health (NIH) through the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What types of conditions does the announcement expect projects to include?
The announcement emphasizes covering the broader FASD continuum, specifically including fetal alcohol syndrome (FAS), partial FAS, and alcohol-related neurodevelopmental disorders, rather than focusing on a single diagnosis.
What is the main outcome these projects are expected to produce?
The main expected outcome is a defensible estimate of FASD prevalence among young children within defined U.S. geographic areas, generated using methods designed to be credible, reproducible, and appropriate for the general population in those areas.
What does “prevalence†mean in the context of this announcement?
In this context, prevalence refers to how common FASD is among young children in a specified population and geographic area (such as a county or city), measured in a way intended to represent the general population living there.
What geographic scope is the program looking for?
The announcement focuses on calculating prevalence rates within clearly defined geographic areas in the United States, such as specific counties or cities. The intent is to produce estimates that are reasonable and generalizable for comparable U.S. communities.
Is the work expected to be population-based?
Yes. The opportunity stresses population-based field work and prevalence calculations intended to reflect the general population living in the defined geographic area.
What is “active case ascertainment,†and is it required?
Active case ascertainment is an approach where research teams actively seek, identify, and clinically evaluate potential cases in the target population rather than relying only on existing diagnoses or passive reporting systems. The announcement indicates projects are expected to use active case ascertainment to avoid undercounting.
Why does the announcement emphasize active case ascertainment?
The stated reason is to avoid undercounting that can occur when studies rely only on existing diagnoses or passive reporting systems. Actively identifying and clinically evaluating potential cases is positioned as a way to produce more credible prevalence estimates.
What role do clinical evaluations play in these projects?
Clinical evaluations are central to the approach described. Teams are expected to identify potential cases and conduct clinical assessments as part of active case ascertainment and standardized diagnosis.
Is a standardized diagnostic system required?
Yes. A central requirement is the development and/or use of a standardized diagnostic system to evaluate clinical characteristics of FASD among affected children. Applicants are expected to use a clear, consistent, and defensible approach for determining who meets criteria for FASD-related diagnoses.
Why is standardization of diagnosis important in this program?
The announcement links standardized diagnostics to methodological rigor and comparability. Standardized case definitions and consistent assessment procedures are intended to help estimates be compared across sites and repeated over time, supporting prevalence calculations that policymakers and public health leaders can trust.
What is CoFASP, and how is it connected to this RFA?
CoFASP refers to the Collaboration on FASD Prevalence. NIAAA frames this effort as part of CoFASP and describes this cohort as the final group of awardees supported under this request for applications.
What grant mechanism is used for this opportunity?
Funding is offered through a cooperative agreement mechanism (U01).
What does the U01 cooperative agreement imply about NIH involvement?
The announcement notes that a cooperative agreement generally indicates substantial scientific or programmatic involvement by the federal agency during the project period compared to a typical research project grant.
How much total funding is expected to be available?
The total estimated funding available is about $2,000,000.
How many awards are anticipated?
The announcement anticipates one to three awards, depending on available funds and application quality.
How long can the project period last?
The project period can be up to five years.
What level of annual direct costs does the announcement expect?
Proposed direct costs are expected to fall roughly between $500,000 and $1,400,000 per year across the five-year period.
Why are the budgets described as relatively large?
The funding range is presented as reflecting the scale and logistical demands of active case ascertainment and standardized clinical assessment.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
What type of funding is this classified as?
The opportunity is categorized as discretionary funding and is within the health funding activity area.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.273 (Alcohol Research Programs).
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. institutions and governmental entities, such as public and private institutions of higher education, state and local governments (including county, city/township, special district), independent school districts, and a wide range of nonprofit and for-profit organizations.
Are community-based or faith-based organizations eligible?
Yes. The eligibility language explicitly includes faith-based or community-based organizations.
Are minority-serving institutions specifically included in eligibility?
Yes. The announcement explicitly includes historically Black colleges and universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and other community-focused and capacity-building institution types.
Are tribal entities eligible?
Yes. The eligibility list includes tribal governments and tribal organizations, as well as tribally controlled colleges and universities.
Are U.S. territories or possessions eligible?
Yes. The eligibility language includes U.S. territories or possessions.
Are non-U.S. entities eligible to apply?
The announcement lists non-U.S. entities and regional organizations among eligible applicants, signaling openness to certain external partners. At the same time, the research focus described is on U.S. geographic areas and U.S. prevalence estimation.
Does the announcement focus on existing diagnoses or new identification of cases?
It focuses on new identification through active case ascertainment rather than relying only on existing diagnoses or passive reporting systems.
What kinds of research teams does NIAAA expect for these projects?
NIAAA indicates an intent to support multidisciplinary research teams capable of conducting population-based field work, coordinating clinical evaluations, and producing prevalence estimates designed to be credible and generalizable for comparable U.S. communities.
When was the funding announcement posted?
The source information indicates the funding announcement was posted and created on October 23, 2009.
What was the application closing date?
The original and current closing date shown is December 22, 2009.
When was the opportunity archived?
The archive date shown is January 22, 2010.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site.
Who is listed for technical help with access or linking issues?
NIH provided standard technical contact information for access and linking issues through the NIH Office of Extramural Research webmaster.
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