Opportunity Information: Apply for RFA DK 11 025
Apply for RFA DK 11 025
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Causes and Consequences of Cystic Fibrosis Related Diabetes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Oct 5, 2011 and posted on Oct 5, 2011.
- Applicants must submit their applications by Mar 20, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts County governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH), through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), released this Funding Opportunity Announcement titled "Causes and Consequences of Cystic Fibrosis Related Diabetes (R01)" under Funding Opportunity Number RFA-DK-11-025. It supports investigator-initiated Research Project Grants (R01s) focused specifically on cystic fibrosis related diabetes (CFRD), which is one of the most frequent and serious complications seen in people living with cystic fibrosis (CF). The overall purpose is to fund research that explains why CFRD develops in some individuals with CF and not others, and to clarify why CFRD is linked to worse health outcomes, including a faster decline in lung disease and higher illness and death rates compared with CF patients who do not develop diabetes.
From a scientific standpoint, the FOA highlights two major knowledge gaps. First, the underlying causes (etiology) of CFRD are not well understood. While certain genetic variants have been associated with risk, they do not fully explain who develops CFRD or the biological pathways driving the condition. Second, even though CFRD is clearly associated with higher morbidity and mortality in CF, the mechanisms behind these poorer outcomes are still unclear, especially the reasons for a steeper decline in pulmonary function among those with CFRD. NIDDK is therefore looking for projects that can connect the dots between CF, disordered glucose metabolism/insulin secretion, and downstream consequences in organs and systems that matter most for long-term outcomes in CF, particularly the lungs.
The announcement explicitly invites studies in both humans and animal models. That includes research that investigates how CFRD begins and progresses over time, studies that probe genetic and non-genetic contributors to disease development, and mechanistic work that explains how CFRD worsens clinical status in CF. In practical terms, responsive applications could include laboratory-based mechanistic studies, translational studies that bridge clinical observations to underlying biology, and clinically oriented research that tests specific hypotheses about why CFRD accelerates lung deterioration or increases vulnerability to complications. The emphasis is not just on describing CFRD, but on uncovering causal pathways and consequences that could eventually inform prevention strategies, earlier detection, or better interventions to reduce CFRD-associated harm.
Administratively, this is a discretionary grant opportunity using the NIH R01 mechanism. It was posted on October 5, 2011, with an original and current closing date of March 20, 2012, and it was archived on April 20, 2012. The estimated total funding amount listed for the FOA is $1,500,000. The activity category is listed under Health and Food and Nutrition, and the associated CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). No cost sharing or matching is required, which is typical for many NIH research project grants.
Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with distinctions noted), small businesses, for-profit organizations other than small businesses, and various government entities such as state, county, city/township, special district governments, independent school districts, and public/Indian housing authorities. The FOA also specifies eligibility for a number of institution types and community-focused entities, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined by NIH policy, signaling openness to international collaboration and research resources where scientifically justified.
For applicants seeking the official full text and requirements, the FOA points to the NIH Grants Guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-11-025.html. For access or technical issues related to the announcement, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) released through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) titled "Causes and Consequences of Cystic Fibrosis Related Diabetes (R01)." It supports investigator-initiated Research Project Grants using the NIH R01 mechanism.
What is the FOA number?
The Funding Opportunity Number is RFA-DK-11-025.
Which NIH institute is sponsoring this FOA?
The FOA is issued by NIH through NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases).
What research topic is the FOA focused on?
The FOA is focused specifically on cystic fibrosis related diabetes (CFRD), described as one of the most frequent and serious complications in people living with cystic fibrosis (CF).
What is the main purpose of the FOA?
The purpose is to fund research that explains (1) why CFRD develops in some individuals with cystic fibrosis and not others, and (2) why CFRD is linked to worse outcomes, including faster decline in lung disease and higher illness and death rates compared with CF patients who do not develop diabetes.
What major knowledge gaps does the FOA highlight?
The FOA emphasizes two key gaps: (1) the underlying causes (etiology) of CFRD are not well understood, and known genetic risk variants do not fully explain who develops CFRD or the biological pathways involved; and (2) the mechanisms behind the higher morbidity and mortality associated with CFRD are unclear, including why pulmonary function declines more steeply in CF patients with CFRD.
What kinds of studies are invited under this FOA?
The FOA explicitly invites studies in both humans and animal models. It also invites research on how CFRD begins and progresses over time, genetic and non-genetic contributors to CFRD development, and mechanistic studies explaining how CFRD worsens clinical status in cystic fibrosis.
Are human studies allowed?
Yes. The FOA explicitly invites studies in humans.
Are animal model studies allowed?
Yes. The FOA explicitly invites studies in animal models.
Does the FOA prioritize any particular organ system or clinical outcome?
Yes. A central emphasis is connecting CF and disordered glucose metabolism/insulin secretion to downstream consequences that matter for long-term outcomes in CF, particularly the lungs. The FOA highlights the need to explain the steeper decline in pulmonary function observed among those with CFRD.
What types of research approaches are considered responsive?
Based on the FOA description, responsive applications could include laboratory-based mechanistic studies, translational studies that bridge clinical observations to underlying biology, and clinically oriented research testing specific hypotheses about why CFRD accelerates lung deterioration or increases vulnerability to complications.
Is the FOA looking for descriptive studies or causal/mechanistic work?
The emphasis is not just on describing CFRD. The FOA prioritizes uncovering causal pathways and consequences that could eventually inform prevention strategies, earlier detection, or better interventions to reduce CFRD-associated harm.
What grant mechanism is being used?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
Is this an investigator-initiated opportunity?
Yes. The FOA supports investigator-initiated R01 research projects focused on CFRD.
What is the estimated total funding amount for this FOA?
The estimated total funding amount listed is $1,500,000.
Is cost sharing or matching required?
No. The FOA indicates that no cost sharing or matching is required.
What is the activity category associated with this opportunity?
The activity category is listed under Health and Food and Nutrition.
What is the CFDA number associated with this FOA?
The associated CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
When was this FOA posted?
The FOA was posted on October 5, 2011.
What was the application closing date?
The FOA lists an original and current closing date of March 20, 2012.
Is this FOA still active?
No. The FOA was archived on April 20, 2012.
Who is eligible to apply?
Eligibility is broad and includes domestic and international organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, with distinctions noted), small businesses, for-profit organizations other than small businesses, and a range of government entities (state, county, city/township, special districts, independent school districts, and public/Indian housing authorities).
Are minority-serving institutions and community-based organizations eligible?
Yes. The FOA specifies eligibility for multiple institution types and community-focused entities, including HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and regional organizations.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA includes U.S. territories or possessions as eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA indicates eligible federal agencies are included.
Can foreign (non-U.S.) organizations apply?
Yes. The FOA states that non-U.S. entities (foreign institutions) are eligible to apply.
Can non-U.S. components of U.S. organizations apply?
Yes. The FOA states that non-U.S. components of U.S. organizations may apply.
Are foreign components allowed on applications?
Yes. The FOA states that foreign components are allowed as defined by NIH policy, supporting international collaboration where scientifically justified.
Where can applicants find the official full text of the FOA?
The FOA points to the NIH Grants Guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-11-025.html.
Who should be contacted for access or technical issues with the announcement?
For access or technical issues, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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