Opportunity Information: Apply for RFA AG 11 001
Apply for RFA AG 11 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Cell Lineage Determination and Tissue Homeostasis in the Aged (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jun 23, 2010 and posted on Jun 23, 2010.
- Applicants must submit their applications by Oct 7, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Special district governments Private institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments Small businesses Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Institute on Aging (NIA) funding opportunity "Cell Lineage Determination and Tissue Homeostasis in the Aged (R01)" (RFA-AG-11-001) supports research aimed at figuring out how cells in older organisms are replaced, how long different cell types survive, and what they ultimately become over time. The central idea is to improve understanding of tissue homeostasis in aging by directly tracking cell lineages and measuring cell life spans in tissues that tend to lose function later in life. Projects are expected to produce quantitative, trackable readouts of cell turnover and fate decisions, helping clarify how aging changes the balance between cell loss, cell replacement, and functional maintenance in specific tissues.
The FOA is focused on both basic and applied studies that can determine cell fates and turnover rates in aged mammals, either in humans or in aging-relevant model organisms such as rodents, dogs, or nonhuman primates. A key expectation is that applicants will use or develop systems that make lineage tracing and lifespan determination possible in one or more defined cell types, and that these systems will be suitable for detecting age-dependent shifts in turnover dynamics. In practical terms, the program is looking for approaches that can answer questions like whether particular stem or progenitor populations become less productive with age, whether mature cells persist longer because replacement is impaired, or whether injury responses in older tissue reroute lineage pathways in ways that contribute to decline.
While the emphasis is on healthy aging and normal tissue maintenance, the announcement also allows applicants to examine what happens to cell lineages and turnover after perturbations that are especially relevant to older adults. This includes acute injury as well as other stresses such as chronic illness or disease-related challenges. The overall goal is to connect measurable lineage behavior (who gives rise to whom, how fast cells are replaced, and how long they persist) with the broader problem of why tissues become more vulnerable, slower to repair, or less functional with advanced age.
This opportunity uses the NIH Research Project Grant (R01) mechanism and follows standard NIH application, submission, and peer review procedures as laid out in the FOA. For funding, NIA set aside an estimated total of up to $2,000,000 in FY2011 to support up to five awards, with an award ceiling listed at $300,000. Awards are contingent on available funds and on receiving a sufficient number of high-quality, competitive applications that directly match the FOA objectives.
Eligibility is broad and includes many types of domestic and non-domestic entities. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special districts), along with tribal governments and tribal organizations. The FOA also explicitly notes eligibility for groups such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities, faith-based or community-based organizations, U.S. territories or possessions, and foreign organizations. No cost sharing or matching is required.
Key administrative details include the posting and creation date of June 23, 2010, with an original and current closing date of October 7, 2010, and an archive date of November 7, 2010. The CFDA number associated with this opportunity is 93.866 (Aging Research), and the activity category is health. The full announcement was made available through the NIH grants system under the listed additional information link, and NIH Office of Extramural Research support contacts were provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Cell Lineage Determination and Tissue Homeostasis in the Aged (R01)" from the NIH National Institute on Aging (NIA). The FOA number is RFA-AG-11-001.
What is the main purpose of this FOA?
The FOA supports research that improves understanding of tissue homeostasis in aging by directly tracking cell lineages and measuring cell life spans in tissues that tend to lose function later in life. The goal is to clarify how aging changes the balance between cell loss, cell replacement, and functional maintenance in specific tissues.
What kinds of scientific questions is the program trying to answer?
The program is looking for approaches that can produce measurable answers to questions such as: whether particular stem or progenitor populations become less productive with age; whether mature cells persist longer because replacement is impaired; and whether injury responses in older tissue reroute lineage pathways in ways that contribute to decline.
What types of studies are encouraged (basic vs. applied)?
The FOA supports both basic and applied studies, as long as they can determine cell fates and turnover rates in aged mammals and align with the goal of understanding tissue homeostasis in aging through direct lineage tracking and lifespan determination.
What organisms or systems can be used in proposed research?
Studies may be conducted in humans or in aging-relevant model organisms such as rodents, dogs, or nonhuman primates, provided the work can determine cell fates and turnover rates in aged mammals.
What is meant by "cell lineage determination" in the context of this FOA?
In this FOA, cell lineage determination refers to directly tracking which cells give rise to which descendant cell types over time, enabling investigators to measure fate decisions and how lineage pathways change with advanced age.
What is meant by "tissue homeostasis" in aging?
Here, tissue homeostasis refers to the maintenance of tissue function over time through the balance of cell loss, cell replacement (turnover), and the persistence of functional cells, and how that balance shifts in older organisms.
What is expected in terms of measurement and outputs from funded projects?
Projects are expected to produce quantitative, trackable readouts of cell turnover and fate decisions. The emphasis is on systems and approaches that make lineage tracing and lifespan determination possible in one or more defined cell types, and that can detect age-dependent shifts in turnover dynamics.
Does the FOA focus only on healthy aging, or can it include injuries and other stresses?
While the emphasis is on healthy aging and normal tissue maintenance, the FOA also allows applicants to examine changes in lineages and turnover after perturbations relevant to older adults, including acute injury and other stresses such as chronic illness or disease-related challenges.
What is the overall goal of linking lineage behavior to aging outcomes?
The overall goal is to connect measurable lineage behavior (who gives rise to whom, how fast cells are replaced, and how long they persist) to why tissues become more vulnerable, slower to repair, or less functional with advanced age.
What NIH grant mechanism is used for this opportunity?
This opportunity uses the NIH Research Project Grant (R01) mechanism and follows standard NIH application, submission, and peer review procedures described in the FOA.
How much funding did NIA set aside for this program?
NIA estimated a total of up to $2,000,000 in FY2011 to support up to five awards, contingent on available funds and the receipt of a sufficient number of high-quality, competitive applications that match the FOA objectives.
How many awards were anticipated?
Up to five awards were anticipated, depending on available funds and the quality and relevance of applications.
Is there an award ceiling mentioned in the FOA?
Yes. The FOA lists an award ceiling of $300,000.
Are awards guaranteed if an application is submitted?
No. Awards are contingent on available funds and on receiving a sufficient number of high-quality, competitive applications that directly match the FOA objectives.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic entities. Eligible applicants include public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and multiple levels of government (state, county, city/township, special districts), along with tribal governments and tribal organizations.
Are foreign organizations eligible to apply?
Yes. The FOA explicitly notes eligibility for foreign organizations.
Are specific institution types explicitly noted as eligible?
Yes. The FOA explicitly notes eligibility for groups such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities, faith-based or community-based organizations, and U.S. territories or possessions.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
What is the CFDA number for this opportunity?
The CFDA number associated with this opportunity is 93.866 (Aging Research).
What is the activity category?
The activity category is health.
When was this FOA posted and created?
The posting and creation date listed is June 23, 2010.
What were the closing dates for the opportunity?
The original and current closing date listed is October 7, 2010.
When was the FOA archived?
The archive date listed is November 7, 2010.
Where was the full announcement made available?
The full announcement was made available through the NIH grants system under the FOA's additional information link. The FOA also notes that NIH Office of Extramural Research support contacts were provided for access or linking issues.
What is a key expectation for approaches proposed under this FOA?
A key expectation is that applicants will use or develop systems that make lineage tracing and lifespan determination possible in one or more defined cell types, and that these systems are suitable for detecting age-dependent shifts in turnover dynamics.
What types of tissues are emphasized?
The FOA emphasizes tissues that tend to lose function later in life, with the aim of measuring cell turnover and fate decisions to understand how functional maintenance changes with age.
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