Opportunity Information: Apply for RFA HL 10 027
Apply for RFA HL 10 027
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Cellular and Molecular Mechanisms of Arterial Stiffening and Its Relationship to Development of Hypertension (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Oct 19, 2009 and posted on Oct 19, 2009.
- Applicants must submit their applications by Jan 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $16,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Independent school districts County governments Small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The funding opportunity titled "Cellular and Molecular Mechanisms of Arterial Stiffening and Its Relationship to Development of Hypertension (R01)" (Funding Opportunity Number RFA-HL-10-027) is an NHLBI initiative under the National Institutes of Health focused on understanding why large, conduit arteries become stiff and how that stiffening connects to the onset and progression of hypertension. The core scientific emphasis is on basic research, meaning proposals are expected to dig into fundamental physiology and the underlying cellular and molecular pathways that drive arterial stiffening, particularly in the setting of high blood pressure. A major theme is timing and causality: the FOA explicitly encourages studies that clarify the temporal relationship between arterial stiffening and hypertension development, with an emphasis on animal models that allow investigators to observe whether stiffening precedes hypertension, follows it, or evolves alongside it in a mechanistically informative way.
This announcement uses the NIH Research Project Grant (R01) mechanism, so it is designed for hypothesis-driven, investigator-initiated research projects with clearly defined aims, rigorous experimental approaches, and well-justified models and methods. The work is categorized under health research in cardiovascular diseases (CFDA 93.837, Cardiovascular Diseases Research). There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of receiving an award.
In terms of funding scale and expected awards, NHLBI indicated an intention to commit about $4 million in total costs in fiscal year 2010, with up to $16 million in total costs anticipated across four years for this program. The institute planned to fund up to 10 grants under the FOA, but awards were contingent on the availability of funds and the receipt of a sufficient number of high-quality, competitive applications. The listing includes an award ceiling of $250,000 (as provided in the source data), which is an important planning constraint for budgets and scope. The overall structure suggests NHLBI aimed to support a small portfolio of mechanistically strong projects rather than a large number of smaller exploratory studies.
Eligibility is broad and includes many types of U.S. organizations as well as non-U.S. entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (including those other than higher education), for-profit organizations (including small businesses and other for-profits), and a wide range of governmental entities such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly recognizes and includes organizations serving specific communities and missions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and tribal organizations or governments (both federally recognized and other than federally recognized). Additional eligible applicants include U.S. territories or possessions, regional organizations, faith-based or community-based organizations, eligible federal agencies, and foreign (non-U.S.) organizations, indicating NHLBI was open to a wide range of institutional homes as long as the proposed science aligned with the program goals and met NIH requirements.
Administratively, the FOA was posted and created on October 19, 2009, with an original and current closing date of January 20, 2010, and an archive date of February 20, 2010. The full announcement was made available through the NIH grants guide (link provided in the source), and applicants who had trouble accessing the announcement were directed to contact the NIH Office of Extramural Research (OER) webmaster. Overall, the opportunity was designed to advance foundational knowledge about arterial stiffening mechanisms and how those mechanisms intersect with hypertension, with the expectation that improved mechanistic insight could inform future strategies for prevention, early detection, and intervention in hypertension-related vascular disease.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Cellular and Molecular Mechanisms of Arterial Stiffening and Its Relationship to Development of Hypertension (R01)" and the Funding Opportunity Number is RFA-HL-10-027.
Which agency is offering this funding opportunity?
This is an initiative from the National Heart, Lung, and Blood Institute (NHLBI) under the National Institutes of Health (NIH).
What is the main purpose of this funding opportunity?
The purpose is to improve understanding of why large, conduit arteries become stiff and how arterial stiffening is connected to the onset and progression of hypertension.
What kind of research does the FOA emphasize?
The FOA emphasizes basic research focused on fundamental physiology and the cellular and molecular pathways that drive arterial stiffening, particularly in the setting of high blood pressure.
How important is the relationship between timing and causality in proposed projects?
Timing and causality are central themes. The FOA encourages studies that clarify the temporal relationship between arterial stiffening and hypertension development, such as whether stiffening precedes hypertension, follows it, or evolves alongside it in a mechanistically informative way.
Are particular study systems or approaches encouraged?
Yes. The FOA places emphasis on animal models that allow investigators to observe and test the sequence of events linking arterial stiffening and hypertension in a way that supports causal and mechanistic conclusions.
What grant mechanism is used for this opportunity?
The announcement uses the NIH Research Project Grant (R01) mechanism.
What does the R01 mechanism imply about the type of application expected?
It is designed for hypothesis-driven, investigator-initiated research projects with clearly defined aims, rigorous experimental approaches, and well-justified models and methods.
What topic area or program category does this grant fall under?
The work is categorized under health research in cardiovascular diseases and is associated with CFDA 93.837 (Cardiovascular Diseases Research).
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving an award.
How much funding did NHLBI intend to commit to this program?
NHLBI indicated an intention to commit about $4 million in total costs in fiscal year 2010, with up to $16 million in total costs anticipated across four years for the program.
How many awards were expected?
NHLBI planned to fund up to 10 grants, contingent on the availability of funds and the receipt of a sufficient number of high-quality, competitive applications.
Is there an award ceiling for this opportunity?
Yes. The listing includes an award ceiling of $250,000 (as provided in the source data), which is an important constraint for budgeting and project scope.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and non-U.S. entities, as long as the proposed science aligns with the program goals and meets NIH requirements.
Are U.S. colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status are eligible, including those other than higher education.
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, including small businesses and other for-profit entities.
Are government entities eligible to apply?
Yes. A wide range of governmental entities are eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Does the FOA include institutions serving specific communities (for example, HBCUs or tribal colleges)?
Yes. The FOA explicitly recognizes and includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and tribal organizations or governments (both federally recognized and other than federally recognized).
Are U.S. territories or regional organizations eligible?
Yes. Additional eligible applicants include U.S. territories or possessions and regional organizations.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed among eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the eligibility list.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. Foreign (non-U.S.) organizations are explicitly included among eligible applicants.
When was the FOA posted?
The FOA was posted and created on October 19, 2009.
What was the application closing date?
The original and current closing date listed is January 20, 2010.
When was the opportunity archived?
The archive date listed is February 20, 2010.
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide (a link was provided in the source information).
What should an applicant do if they have trouble accessing the announcement?
Applicants who had trouble accessing the announcement were directed to contact the NIH Office of Extramural Research (OER) webmaster.
What broader impact is this opportunity aiming for?
The opportunity is intended to advance foundational knowledge about arterial stiffening mechanisms and how those mechanisms intersect with hypertension, with the expectation that improved mechanistic insight could inform future strategies for prevention, early detection, and intervention in hypertension-related vascular disease.
Browse more opportunities from the same category: Health
Next opportunity: Track II Dialogue on Denuclearization of the Korean Peninsula
Previous opportunity: U.S. Nuclear Regulatory Commission Funding Opportunity Announcement, Trade School and Community College Scholarship Grant, Fiscal Year 2010
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA HL 10 027
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA HL 10 027) also looked into and applied for these:
| Funding Opportunity |
|---|
| NHLBI Cardiovascular Outcomes Research Coordinating Unit (U01) Apply for RFA HL 10 018 Funding Number: RFA HL 10 018 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NHLBI Centers for Cardiovascular Outcomes Research (U01) Apply for RFA HL 10 008 Funding Number: RFA HL 10 008 Agency: National Institutes of Health Category: Health Funding Amount: $920,000 |
| Medical Liability Reform and Patient Safety Planning Grants (R21) Apply for RFA HS 10 022 Funding Number: RFA HS 10 022 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $300,000 |
| Medical Liability Reform and Patient Safety Demonstration Projects (R18) Apply for RFA HS 10 021 Funding Number: RFA HS 10 021 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $3,000,000 |
| Roadmap Transformative Research Projects Program (R01) Apply for RFA RM 09 022 Funding Number: RFA RM 09 022 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Case Ascertainment to Estimate the U.S. Prevalence of Fetal Alcohol Spectrum Disorders in Young Children (U01) Apply for RFA AA 10 005 Funding Number: RFA AA 10 005 Agency: National Institutes of Health Category: Health Funding Amount: $1,400,000 |
| Metagenomic Evaluation of Oral Polymicrobial Disease (R01) Apply for RFA DE 10 003 Funding Number: RFA DE 10 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Grants to Expand Substance Abuse Treatment Capacity in Targeted Areas of Need Local Recovery Oriented Systems of Care Apply for TI 10 007 Funding Number: TI 10 007 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $400,000 |
| Population Based Birth Defects Surveillance and Utilization of Surveillance Data by Public Health Programs Apply for CDC RFA DD10 1001 Funding Number: CDC RFA DD10 1001 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $220,000 |
| Preventing Unintentional Childhood Injuries (R21) Apply for RFA CE 10 001 Funding Number: RFA CE 10 001 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $175,000 |
| Public Health Conference Support Program Apply for CDC RFA DD10 1003 Funding Number: CDC RFA DD10 1003 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $100,000 |
| Research Grants for Preventing Violence and Violence Related Injury (R01) Apply for RFA CE 10 005 Funding Number: RFA CE 10 005 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $400,000 |
| Research Priorities in Acute Injury Care (R01) Apply for RFA CE 10 003 Funding Number: RFA CE 10 003 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $600,000 |
| Development and Characterization of Animal Models for Aging Research (R01) Apply for PA 10 014 Funding Number: PA 10 014 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Unintentional Poisoning from Prescription Drug Overdoses in Adults (R21) Apply for RFA CE 10 002 Funding Number: RFA CE 10 002 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $350,000 |
| Development and Characterization of Animal Models for Aging Research (R21) Apply for PA 10 015 Funding Number: PA 10 015 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| NEI Clinical Study Planning Grant Program (R34) Apply for PAR 10 017 Funding Number: PAR 10 017 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Technologies for Image Guided Interventions (R01) Apply for RFA EB 09 002 Funding Number: RFA EB 09 002 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| FY10 Announcement of Anticipated Availability of Funds for Family Planning Services Grants (Central Pennsylvania). Apply for PA FPH 10 008 Funding Number: PA FPH 10 008 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: $2,959,200 |
| FY10 Announcement of Anticipated Availability of Funds for Family Planning Services Grants (Michigan and Illinois) Apply for PA FPH 10 009 Funding Number: PA FPH 10 009 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: $8,308,700 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA HL 10 027", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.