Opportunity Information: Apply for RFA AT 14 006
Apply for RFA AT 14 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Center for Advancing Natural Products Innovation and Technology (U41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Dec 5, 2013 and posted on Dec 5, 2013.
- Applicants must submit their applications by Jun 27, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) County governments For profit organizations other than small businesses State governments Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-AT-14-006 seeks applications to create a national Center for Advancing Natural Product Innovation and Technology (CANPIT) using the U41 cooperative agreement mechanism. The purpose of the center is to push natural products research forward by strengthening and modernizing the technologies and methods used to study natural products, with an emphasis on solving persistent technical bottlenecks that limit progress in the field. Rather than focusing on a single disease area or a narrow set of compounds, the announcement frames CANPIT as a broadly enabling, field-wide resource whose work should meaningfully improve how natural products are chemically characterized and biologically investigated.
A major expectation is that CANPIT will develop and/or adapt cutting-edge approaches that can have high impact across the natural products pipeline. In practical terms, this points to innovations in areas like analytical chemistry workflows, compound identification and structural elucidation, metabolomics and related omics methods, standardization and quality control approaches, bioassay integration, data handling, and other technologies that can reduce uncertainty, improve reproducibility, and increase throughput. The FOA highlights the need to overcome current research limitations, meaning applicants should be prepared to show that their proposed technology and methods agenda is explicitly designed to address known gaps or pain points in the field, and that the outputs will be usable by the broader community rather than confined to a single laboratory.
Another central feature of the opportunity is the leadership and coordination role CANPIT is expected to play. The center is not only intended to generate technical advances, but also to actively coordinate intellectual and scientific discourse and to disseminate methods, guidance, and best practices to the wider natural products research community. This dissemination emphasis implies that CANPIT should function as a hub: convening researchers, organizing the exchange of technical know-how, promoting harmonized practices, and making resulting protocols, workflows, and lessons learned accessible so other groups can adopt them. The end goal is broad uptake of improved methodology, which in turn strengthens the rigor and comparability of natural products research outputs across institutions.
The announcement is explicitly linked to a companion program from the Office of Dietary Supplements (ODS), the Botanical Dietary Supplement Research Centers Program (RFA-OD-14-001). CANPIT is positioned to complement and amplify that program by collaborating with those centers and with other NIH-supported grantees. A specific collaboration pathway mentioned is the use of CANPIT Technology Demonstration Projects (TDPs), which are meant to connect CANPIT capabilities with real-world research needs in active projects supported by NCCAM (now NCCIH), ODS, and NIH more broadly. In effect, the FOA signals that strong applications will not treat CANPIT as an isolated technology shop, but as an interactive national resource that tests, demonstrates, and refines methods in partnership settings where the improvements can be validated and showcased.
From an administrative standpoint, this is a discretionary grant opportunity issued by the National Institutes of Health under CFDA 93.213 (Research and Training in Complementary and Integrative Health). The funding instrument is a cooperative agreement (U41), which typically means NIH expects substantial programmatic involvement during the life of the award, such as coordination on priorities, milestones, collaborations, and dissemination activities. The opportunity was posted December 5, 2013, with an original and current closing date of June 27, 2014, and an archive date of July 28, 2014.
The FOA lists an estimated total funding amount of $2,000,000 and an award ceiling of $750,000, with no cost sharing or matching requirement. Eligibility is broad across U.S.-based organizations and includes public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations other than small businesses, and various levels of government (state, county, city/township, special districts), as well as eligible tribal governments and tribal organizations. It also explicitly includes categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander serving institutions. Foreign institutions and non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
Overall, the opportunity is best understood as NIH investing in a national-scale enabling center that upgrades the technical foundation of natural products science. The defining features are (1) technology and methods innovation aimed at removing entrenched limitations in natural products research, (2) a leadership role in coordinating the community and spreading best practices, and (3) active collaboration and demonstration work with NIH-supported botanical and natural products researchers, especially through the companion Botanical Dietary Supplement Research Centers and CANPIT Technology Demonstration Projects.
Frequently Asked Questions (FAQs)
What is RFA-AT-14-006 funding?
RFA-AT-14-006 is an NIH funding opportunity seeking applications to create a national Center for Advancing Natural Product Innovation and Technology (CANPIT). The center is intended to be a broadly enabling, field-wide resource that improves the technologies and methods used in natural products research.
What is CANPIT?
CANPIT stands for the Center for Advancing Natural Product Innovation and Technology. It is envisioned as a national-scale center that modernizes and strengthens natural products research by developing, adapting, and disseminating high-impact technologies, methods, and best practices.
What is the main purpose of this center?
The purpose is to push natural products research forward by solving persistent technical bottlenecks that limit progress in the field. The emphasis is on improving how natural products are chemically characterized and biologically investigated in ways the broader research community can use.
Is this opportunity focused on a specific disease area?
No. The announcement frames CANPIT as a broadly enabling resource rather than a center focused on a single disease area or a narrow set of compounds. The goal is field-wide impact across the natural products research pipeline.
What kinds of technical bottlenecks is CANPIT expected to address?
The FOA emphasizes overcoming current research limitations and known gaps in natural products research. Examples of areas called out include analytical chemistry workflows, compound identification and structural elucidation, metabolomics and related omics methods, standardization and quality control, bioassay integration, and data handling approaches that improve reproducibility and throughput.
What types of outputs is CANPIT expected to produce?
CANPIT is expected to generate usable, high-impact technologies, methods, protocols, workflows, and guidance that can be adopted by the broader natural products research community, not just used within a single laboratory.
What does the FOA mean by CANPIT being a "field-wide resource"?
It means the center should function as a national hub whose work improves the overall technical foundation of natural products science. The improvements should be broadly applicable, disseminated widely, and designed for uptake by other institutions and researchers.
What role does dissemination play in this opportunity?
Dissemination is a central expectation. CANPIT is intended not only to develop technical advances, but also to coordinate scientific discourse and spread methods, guidance, and best practices so other groups can adopt harmonized approaches.
How is CANPIT expected to support coordination and leadership in the community?
The center is expected to act as a hub that convenes researchers, organizes the exchange of technical know-how, promotes standardized and harmonized practices, and makes resulting protocols and lessons learned accessible to the wider natural products research community.
What are Technology Demonstration Projects (TDPs) in this FOA?
The FOA describes CANPIT Technology Demonstration Projects (TDPs) as a collaboration pathway to connect CANPIT capabilities with real-world research needs in active NIH-supported projects. These projects are meant to test, demonstrate, refine, and showcase methods in partnership settings.
Which NIH-related programs is CANPIT linked to?
The announcement is explicitly linked to a companion program from the Office of Dietary Supplements (ODS): the Botanical Dietary Supplement Research Centers Program (RFA-OD-14-001). CANPIT is positioned to complement and amplify that program by collaborating with those centers and other NIH-supported grantees.
Is CANPIT expected to operate independently or collaboratively?
The FOA signals that CANPIT should not be treated as an isolated technology shop. Strong applications are expected to position the center as an interactive national resource that collaborates with NIH-supported researchers and validates improvements through partnerships and demonstration work.
What is the funding mechanism for this opportunity?
The funding instrument is a cooperative agreement (U41). This typically indicates NIH expects substantial programmatic involvement during the life of the award, such as coordination on priorities, milestones, collaborations, and dissemination activities.
What does NIH involvement typically imply under a U41 cooperative agreement?
Based on the FOA description, NIH programmatic involvement may include coordination related to priorities, milestones, collaborations, and dissemination efforts during the award period.
Which NIH category or CFDA listing is associated with this opportunity?
This discretionary grant opportunity is issued under CFDA 93.213, Research and Training in Complementary and Integrative Health.
How much total funding is estimated for this FOA?
The FOA lists an estimated total funding amount of $2,000,000.
What is the award ceiling?
The FOA lists an award ceiling of $750,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and includes public and private institutions of higher education, nonprofit organizations (501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations other than small businesses, and various levels of government (state, county, city/township, and special districts), as well as eligible tribal governments and tribal organizations.
Are minority-serving institutions explicitly included?
Yes. The FOA explicitly includes categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander serving institutions.
Are foreign institutions eligible to apply?
No. Foreign institutions and non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
What are the key defining features NIH emphasizes for this center?
The opportunity is defined by (1) technology and methods innovation aimed at removing entrenched limitations in natural products research, (2) a leadership role in coordinating the community and spreading best practices, and (3) active collaboration and demonstration work with NIH-supported botanical and natural products researchers, including through companion centers and Technology Demonstration Projects.
When was this funding opportunity posted and when did it close?
The opportunity was posted on December 5, 2013. The original and current closing date listed is June 27, 2014, and the archive date is July 28, 2014.
Is this opportunity still open?
Based on the dates provided, the closing date was June 27, 2014 and the archive date was July 28, 2014, indicating the opportunity is not currently open.
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