Opportunity Information: Apply for PAR 16 379

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Center of Excellence for Research on Complementary and Integrative Health (P01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
  • This funding opportunity was created on Jul 29, 2016.
  • Applicants must submit their applications by Jan 07, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PAR 16 379

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Opportunity Summary:

The Center of Excellence for Research on Complementary and Integrative Health (CERCIH) (P01) funding opportunity (PAR-16-379) is a National Institutes of Health grant program administered by the Department of Health and Human Services, specifically aligned with the mission priorities of the National Center for Complementary and Integrative Health (NCCIH). The core purpose of this opportunity is to build a coordinated research center that goes beyond what a set of separate, stand-alone grants could accomplish. Instead of funding isolated projects, the program is structured to support a deliberately integrated, multi-project research effort where investigators work together in a way that produces clear scientific added value through collaboration, shared infrastructure, and complementary expertise.

A key requirement of the CERCIH model is that an application must include at least three highly meritorious research projects that are intentionally designed to be synergistic. In practice, this means the projects should not simply sit next to each other under one umbrella; they should actively reinforce one another through shared hypotheses, linked aims, harmonized methods, common populations or datasets where appropriate, and coordinated analysis strategies. The FOA emphasizes multi-disciplinary teams and the blending of multiple research approaches, reflecting the reality that many complementary and integrative health questions involve complex interactions among biological, behavioral, social, and clinical factors. A strong center application, therefore, is expected to demonstrate why the collective, collaborative structure is essential, and to make a convincing case that the combined program will generate insights, efficiencies, or innovations that would be unlikely if the same projects were funded independently.

The scientific scope is anchored to topics of high relevance to NCCIH. While the FOA summary does not list specific scientific areas in the excerpt provided, the intent is clear: proposed research must directly advance NCCIH-aligned questions in complementary and integrative health. In practical terms, this typically means the center should address rigorous, impactful questions about interventions, mechanisms, outcomes, implementation, or other priority areas within complementary and integrative health, with a level of methodological strength appropriate for NIH-supported research. The emphasis on “questions of high relevance” signals that applications should be strategically aligned with NCCIH’s mission rather than broadly health-related or only tangentially connected to complementary and integrative health.

From an administrative standpoint, the opportunity is categorized as a discretionary grant under the NIH umbrella, with a funding activity category of Health and a CFDA number of 93.213. The program anticipated a small number of awards (expected awards: 2), which typically implies a competitive selection process and a strong premium on clear significance, innovation, synergy, and demonstrated capability to manage a complex, multi-project center. The listed award ceiling is $1,250,000, indicating the maximum amount expected per award under this announcement (as provided in the source data). The FOA was created on July 29, 2016, and the original closing date was January 7, 2020, meaning it was time-bound as published in that cycle.

Eligibility is broad and includes many types of applicant organizations that commonly participate in NIH research funding. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed under the FOA’s additional eligibility language. This breadth suggests the program is designed to attract strong, research-capable institutions and consortia, provided they can assemble the leadership, multi-disciplinary expertise, and operational capacity needed to run a coordinated center-style program.

Overall, this CERCIH (P01) opportunity is best understood as a center mechanism intended to accelerate progress in complementary and integrative health by funding integrated clusters of projects that share a coherent scientific theme and gain power through collaboration. It favors applications that can demonstrate true interdependence among projects, strong leadership and team science, and a well-justified argument that the center structure will produce results that are meaningfully greater than the sum of its parts, all while staying tightly aligned with NCCIH’s mission and priorities.

Frequently Asked Questions (FAQs): Center of Excellence for Research on Complementary and Integrative Health (CERCIH) (P01) - PAR-16-379

What is the CERCIH (P01) funding opportunity?

The Center of Excellence for Research on Complementary and Integrative Health (CERCIH) (P01) is a National Institutes of Health (NIH) grant funding opportunity (PAR-16-379) administered by the U.S. Department of Health and Human Services (HHS). It is aligned with the mission priorities of the National Center for Complementary and Integrative Health (NCCIH) and is designed to support a coordinated, integrated research center rather than a set of separate, stand-alone research grants.

Which federal agency and NIH institute/center are associated with this opportunity?

This is an NIH grant program under HHS and is specifically aligned with NCCIH (National Center for Complementary and Integrative Health).

What is the main purpose of this program?

The purpose is to build a deliberately integrated, multi-project research center that can accomplish more than independent projects could accomplish on their own. The program expects clear added scientific value from collaboration, shared infrastructure, and complementary expertise across projects.

How is a CERCIH center different from submitting multiple separate research grants?

Instead of funding isolated projects that happen to be related, this mechanism supports a coordinated program where projects are intentionally interdependent. The expectation is that the center structure creates measurable scientific and operational advantages (for example: shared resources, harmonized methods, coordinated analyses, and strengthened team science) that would be unlikely if the projects were funded independently.

How many research projects are required in a CERCIH application?

An application must include at least three highly meritorious research projects.

Do the required projects need to be related to each other?

Yes. The projects must be intentionally designed to be synergistic, meaning they should actively reinforce each other rather than simply being grouped together under one umbrella.

What does “synergy” mean in the context of this FOA?

Synergy means the projects are connected in a way that produces clear added scientific value through collaboration. Examples described in the opportunity include shared hypotheses, linked aims, harmonized methods, common populations or datasets where appropriate, and coordinated analysis strategies.

Is a multidisciplinary approach expected?

Yes. The FOA emphasizes multi-disciplinary teams and blending multiple research approaches, reflecting the complex biological, behavioral, social, and clinical factors often involved in complementary and integrative health research questions.

What kinds of research topics are appropriate for this opportunity?

Proposed research must directly advance questions aligned with NCCIH priorities in complementary and integrative health. While the excerpt does not list specific topic areas, it emphasizes that projects should address rigorous, impactful questions relevant to NCCIH rather than being broadly health-related or only loosely connected to complementary and integrative health.

Does the FOA require strong research methods and rigor?

Yes. The opportunity highlights the need for methodological strength appropriate for NIH-supported research and for proposing impactful questions of high relevance to NCCIH.

What is the CFDA number for this funding opportunity?

The CFDA number listed is 93.213.

How is this opportunity categorized in terms of grant type and activity area?

It is described as a discretionary grant under the NIH umbrella, with a funding activity category of Health.

How many awards were expected under this announcement?

The opportunity anticipated a small number of awards, with expected awards listed as 2.

What does the small expected number of awards imply for applicants?

With only about two expected awards, the selection process is likely to be competitive. The FOA places emphasis on significance, innovation, synergy among projects, and demonstrated capability to manage a complex, multi-project center.

What is the maximum award amount (award ceiling) mentioned?

The listed award ceiling is $1,250,000 (the maximum amount expected per award under this announcement, as provided in the source information).

When was this FOA created and when did it close?

The FOA was created on July 29, 2016. The original closing date was January 7, 2020, indicating the published cycle was time-bound.

Who is eligible to apply?

Eligibility is broad and includes: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed under the FOA’s additional eligibility language.

Are both nonprofit and for-profit organizations eligible?

Yes. The eligibility list explicitly includes nonprofit organizations (with or without 501(c)(3) status, with certain exclusions noted) as well as for-profit organizations other than small businesses, and also small businesses.

Are tribal entities eligible to apply?

Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are included in the eligibility list.

Are government entities eligible to apply?

Yes. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts.

What does the FOA expect regarding the “center” structure?

The FOA expects applicants to justify why a center structure is essential, showing that collaboration, shared infrastructure, and complementary expertise will produce outcomes that are meaningfully greater than the sum of individual projects.

What are common characteristics of a strong CERCIH center application based on this description?

Based on the information provided, a strong application would: (1) include at least three highly meritorious projects; (2) demonstrate true synergy and interdependence among projects; (3) present a coherent scientific theme; (4) show multi-disciplinary team science and complementary expertise; (5) include shared approaches such as harmonized methods, linked aims, and coordinated analyses where appropriate; and (6) stay tightly aligned with NCCIH mission priorities in complementary and integrative health.

Does the opportunity prioritize research that is only broadly related to health?

No. The emphasis on “questions of high relevance” to NCCIH signals that applications should be strategically aligned with complementary and integrative health priorities rather than being broadly health-related or only tangentially connected.

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