Opportunity Information: Apply for RFA HD 13 004
Apply for RFA HD 13 004
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Centers for Collaborative Research in Fragile X (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 2, 2012 and posted on Oct 2, 2012.
- Applicants must submit their applications by Jan 30, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Native American tribal governments (Federally recognized) Small businesses Special district governments Public and State controlled institutions of higher education For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Centers for Collaborative Research in Fragile X (U01) opportunity (Funding Opportunity Number RFA-HD-13-004) is an NIH discretionary grant program designed to support multi-investigator research Centers focused on Fragile X syndrome and conditions related to the FMR1 gene. The core idea behind the announcement is to fund collaborative, transdisciplinary teams that work in a coordinated way to answer clearly defined scientific questions, rather than funding isolated projects that operate independently. NIH framed these Centers as a way to close key research gaps, accelerate discovery, and strengthen the pipeline of research that can improve understanding, diagnosis, and ultimately intervention strategies for Fragile X syndrome and FMR1-related conditions.
This FOA uses the cooperative agreement mechanism (U01), which typically means the funded Centers would carry out their research with substantial scientific or programmatic involvement from NIH staff compared to a standard investigator-initiated grant. In practice, a U01 often emphasizes active coordination, shared milestones, and a structured plan for collaboration and data/resource sharing, consistent with the Center model described in the announcement. The Centers are expected to be built around targeted research areas selected to address unmet needs in the field, with teams intentionally composed across disciplines so that complex Fragile X questions can be tackled using complementary expertise (for example, integrating clinical insights with neuroscience, genetics, molecular biology, or other relevant fields).
From an administrative standpoint, the opportunity falls under NIH health-related research categories and is listed under multiple CFDA numbers: 93.242 (Mental Health Research Grants), 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), and 93.865 (Child Health and Human Development Extramural Research). The FOA does not require cost sharing or matching funds, lowering the barrier for participation by eligible institutions that may not have the ability to provide institutional matching support.
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include state, county, city/township, special district governments, and federally recognized tribal governments, along with a wide range of nonprofit and educational organizations. Both public and state-controlled institutions of higher education and private institutions of higher education are eligible, as are independent school districts, public housing authorities/Indian housing authorities, and certain for-profit entities (including small businesses, and for-profit organizations other than small businesses). The eligibility language also explicitly includes a range of mission-focused and community-anchored institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. At the same time, the FOA clearly restricts foreign participation: non-U.S. (non-domestic) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them) are not allowed under this announcement.
Timing details indicate that the opportunity was posted and created on October 2, 2012, with an original and current closing date of January 30, 2013, and an archive date of March 2, 2013. That means this specific announcement is no longer active, but it remains a useful reference point for understanding NIH’s Center-based approach to Fragile X research and the types of collaborative, gap-driven projects NIH has sought to stimulate in this area.
For applicants or researchers looking for the full original requirements, expectations, and any special instructions that were included in the complete FOA, NIH provided an additional information link to the archived announcement page: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-13-004.html. For access or technical issues related to the electronic announcement, the contact point listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, including help for difficulties accessing the full announcement or problems linking to the funding notice.
Frequently Asked Questions (FAQs)
What is the "Centers for Collaborative Research in Fragile X (U01)" opportunity?
It is an NIH discretionary grant program designed to support multi-investigator research Centers focused on Fragile X syndrome and conditions related to the FMR1 gene. The opportunity is associated with Funding Opportunity Number (FON) RFA-HD-13-004.
What is the main goal of this funding opportunity?
The goal is to fund collaborative, transdisciplinary research Centers that work in a coordinated way to answer clearly defined scientific questions in Fragile X and FMR1-related conditions. NIH framed these Centers to help close key research gaps, accelerate discovery, and strengthen the research pipeline that can improve understanding, diagnosis, and ultimately intervention strategies.
How is this different from funding separate, independent projects?
The announcement emphasizes coordinated Center-based work rather than isolated projects operating independently. The expectation is that teams collaborate intentionally, share plans and milestones, and approach Fragile X questions using complementary expertise across disciplines.
What funding mechanism does this FOA use?
This FOA uses the cooperative agreement mechanism (U01).
What does the U01 cooperative agreement mechanism generally imply for applicants?
A U01 typically involves substantial scientific or programmatic involvement from NIH staff compared to a standard investigator-initiated grant. In practice, this often means active coordination, shared milestones, and a structured plan for collaboration and data/resource sharing, consistent with the Center model described in the announcement.
What scientific areas or topics are the Centers expected to focus on?
The Centers are expected to be built around targeted research areas selected to address unmet needs in the field of Fragile X syndrome and FMR1-related conditions. The FOA describes an intent to tackle complex questions through integrated, cross-disciplinary approaches (for example, integrating clinical insights with neuroscience, genetics, molecular biology, or other relevant fields).
Is this opportunity focused only on Fragile X syndrome?
No. It focuses on Fragile X syndrome and conditions related to the FMR1 gene.
What kinds of research teams does NIH want to support under this Center model?
NIH describes an interest in collaborative, transdisciplinary teams intentionally composed across disciplines so that complex Fragile X questions can be addressed using complementary expertise.
What CFDA numbers are associated with this opportunity?
The opportunity is listed under multiple CFDA numbers: 93.242 (Mental Health Research Grants), 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), and 93.865 (Child Health and Human Development Extramural Research).
Is cost sharing or matching required?
No. The FOA does not require cost sharing or matching funds.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include various levels of government (state, county, city/township, special district governments, and federally recognized tribal governments) and a wide range of nonprofit, educational, and other organizations.
Are institutions of higher education eligible?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are eligible.
Are school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. Certain for-profit entities are eligible, including small businesses and for-profit organizations other than small businesses.
Are minority-serving or mission-focused institutions included in eligibility?
Yes. The eligibility language explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. It also includes faith-based or community-based organizations and regional organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly included in the eligibility language.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the eligibility language.
Are foreign organizations eligible to apply?
No. Non-U.S. (non-domestic) entities are not eligible to apply under this announcement.
Can a U.S. organization include a non-domestic component in its application?
No. Non-domestic components of U.S. organizations are not eligible under this announcement.
Are "foreign components" allowed?
No. Foreign components (as NIH defines them) are not allowed under this announcement.
When was this funding opportunity posted?
The opportunity was posted and created on October 2, 2012.
What were the application due date and closing date?
The original and current closing date listed is January 30, 2013.
Is this funding opportunity still active?
No. The archive date is March 2, 2013, and the closing date has passed, so this specific announcement is no longer active.
Why might this archived opportunity still be useful?
It can serve as a reference point for understanding NIH's Center-based approach to Fragile X research and the kinds of collaborative, gap-driven projects NIH has sought to stimulate in this area.
Where can I find the full archived FOA text and requirements?
The FOA points to an archived announcement page for full original requirements, expectations, and any special instructions: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-13-004.html.
Who should I contact if I have trouble accessing the electronic announcement?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What types of issues is the OER Webmaster contact intended to help with?
The FOA indicates this contact can help with difficulties accessing the full announcement or problems linking to the funding notice.
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