Opportunity Information: Apply for RFA AI 14 055
Apply for RFA AI 14 055
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers for Medical Countermeasures against Radiation Consortium (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jun 16, 2014 and posted on Jun 16, 2014.
- Applicants must submit their applications by Oct 3, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $21,000,000.00 to eligible and selected applicants.
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Centers for Medical Countermeasures against Radiation Consortium (CMCRC) (U19) funding opportunity, issued by the National Institutes of Health (NIH), is aimed at building a coordinated national network of research centers focused on preparing the United States to respond medically to radiological or nuclear emergencies. The central idea is to support multidisciplinary teams that can move beyond isolated projects and instead operate as a consortium capable of generating practical, usable medical countermeasures for civilians exposed to radiation, whether from a terrorist incident involving a radiological or nuclear device or from an accidental radiation release. The program emphasizes solutions that work across the full range of the civilian population, meaning applicants are expected to consider diverse ages, health conditions, and other factors that affect how radiation injuries present and how treatments perform.
This FOA specifically calls for basic and translational research designed to produce new medical products and capabilities that can assess, diagnose, mitigate, and treat both the short-term and long-term health effects of radiation exposure. In practical terms, it is not limited to immediate lifesaving interventions after exposure, but also includes longer-horizon challenges such as delayed organ damage, chronic tissue injury, and recovery trajectories that unfold over weeks, months, or longer. The expectation is that funded centers will integrate expertise from multiple disciplines (for example, radiation biology, immunology, hematology, bioengineering, pharmacology, biomarker science, device development, and clinical/translational research) to generate countermeasures that are realistic for emergency use and applicable at population scale.
The FOA lays out three major scientific and product-development goals. First, it seeks new techniques and devices that can measure radiation exposure in the human body, which speaks to biodosimetry and exposure assessment tools that could be deployed during an emergency to quickly determine who was exposed, at what approximate dose, and who needs urgent intervention. Second, it prioritizes approaches to track biomarkers of tissue damage and recovery, recognizing that radiation injury can be complex, multi-organ, and time-dependent; reliable biomarkers can support triage, prognosis, treatment decisions, and monitoring of whether a therapy is working. Third, it supports development of novel therapies intended to reduce tissue damage, speed healing, restore normal physiological function, and improve survival, encompassing both mitigating agents given after exposure and treatments for established injury. Collectively, these goals align with the need for end-to-end readiness: knowing the dose, predicting and tracking injury, and having interventions that measurably improve outcomes.
From an administrative and funding standpoint, this opportunity is offered as a cooperative agreement (U19), which generally means NIH anticipates substantial scientific and/or programmatic involvement during the project period compared with a standard grant. The opportunity category is discretionary and falls under the NIH health-related research area, associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting the NIH institute context for managing the program and the overlap between radiation injury, immune dysfunction, infection risk, and systemic inflammatory responses that can follow high-dose exposure.
The estimated total funding listed for the program is 21,000,000, indicating a sizable investment intended to support multiple centers or a multi-component consortium structure rather than a single small project. The FOA was posted on June 16, 2014, with an original and current closing date of October 3, 2014, and an archive date of November 3, 2014, meaning it was a time-limited solicitation for that cycle and is now closed.
Eligibility is broad and intentionally inclusive to attract the strongest teams and infrastructures capable of radiation countermeasure development. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, and a wide range of government entities such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal governments and tribal organizations are also eligible (including federally recognized tribal governments and other tribal entities), and the FOA explicitly notes categories such as HBCUs, Hispanic-serving institutions, tribal colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions. It also mentions eligible agencies of the federal government and faith-based or community-based organizations. At the same time, it draws clear boundaries around foreign participation: non-U.S. (foreign) institutions and non-domestic components of U.S. organizations are not eligible to apply, although foreign components (as defined by NIH policy) are allowed, which typically means discrete collaborations or performance sites may be permissible under NIH rules even when the applicant organization must be U.S.-based.
No cost sharing or matching is required, reducing barriers to participation and allowing applicants to focus their budgets on the research, development, and consortium operations needed to meet the program goals. For full details, NIH provided an additional information link to the official FOA page (http://grants.nih.gov/grants/guide/rfa files/RFA AI 14 055.html). For technical access or linking issues, the contact route listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the CMCRC (U19) funding opportunity?
The Centers for Medical Countermeasures against Radiation Consortium (CMCRC) (U19) is an NIH funding opportunity intended to build a coordinated national network of research centers focused on developing medical countermeasures for radiological or nuclear emergencies affecting civilians.
What is the main purpose of this program?
The program is designed to move beyond isolated research projects by supporting multidisciplinary teams that operate as a consortium. The goal is to generate practical, usable medical countermeasures that can be used at population scale during a radiological or nuclear incident or an accidental radiation release.
What types of emergencies is this program focused on?
The focus is on civilian medical response to radiation exposure from a terrorist incident involving a radiological or nuclear device, as well as from accidental radiation releases.
What kinds of research does the FOA support?
The FOA calls for basic and translational research aimed at producing new medical products and capabilities to assess, diagnose, mitigate, and treat both short-term and long-term health effects of radiation exposure.
Does the program focus only on immediate, short-term radiation injuries?
No. In addition to immediate lifesaving interventions, the FOA includes longer-horizon challenges such as delayed organ damage, chronic tissue injury, and recovery trajectories that develop over weeks, months, or longer.
Who is the target population for the countermeasures developed under this program?
The countermeasures are intended for the full range of the civilian population. Applicants are expected to consider diverse ages, health conditions, and other factors that influence how radiation injuries present and how treatments perform.
What are the major scientific and product-development goals described in the FOA?
The FOA highlights three major goals: (1) develop new techniques and devices to measure radiation exposure in the human body (biodosimetry/exposure assessment); (2) develop approaches to track biomarkers of tissue damage and recovery; and (3) develop novel therapies to reduce tissue damage, speed healing, restore physiological function, and improve survival.
What is biodosimetry in the context of this FOA?
In this FOA, biodosimetry and exposure assessment refer to techniques and devices that can help determine who was exposed to radiation, at approximately what dose, and who needs urgent intervention during an emergency.
Why are biomarkers emphasized in this opportunity?
The FOA emphasizes biomarkers because radiation injury can be multi-organ, complex, and time-dependent. Reliable biomarkers can support triage, prognosis, treatment decisions, and monitoring whether a therapy is working.
What kinds of therapies are within scope for this program?
The FOA supports development of novel therapies intended to mitigate radiation injury after exposure and to treat established injury, including therapies that reduce tissue damage, promote healing, restore normal physiological function, and improve survival.
What disciplines or expertise areas are expected to be integrated?
The FOA expects funded centers to integrate expertise across multiple disciplines, such as radiation biology, immunology, hematology, bioengineering, pharmacology, biomarker science, device development, and clinical/translational research.
What does it mean that this award uses a cooperative agreement mechanism (U19)?
This opportunity is offered as a cooperative agreement (U19), which generally indicates NIH anticipates substantial scientific and/or programmatic involvement during the project period compared with a standard grant mechanism.
Which agency and program area are associated with this FOA?
The funding opportunity is issued by the National Institutes of Health (NIH) and falls under the NIH health-related research area.
What CFDA numbers are associated with this opportunity?
The FOA is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Why are infectious disease and immunology-related areas relevant to radiation countermeasures?
The FOA context reflects overlap between radiation injury and immune dysfunction, infection risk, and systemic inflammatory responses that can follow high-dose exposure.
How much total funding was estimated for the program?
The estimated total funding listed for the program is 21,000,000.
Does the estimated total funding suggest how the program is structured?
Based on the FOA description, the listed total funding level indicates an investment intended to support multiple centers or a multi-component consortium structure rather than a single small project.
When was this FOA posted, and what were the closing and archive dates?
The FOA was posted on June 16, 2014. The original and current closing date was October 3, 2014, and the archive date was November 3, 2014.
Is this funding opportunity currently open?
No. Based on the provided dates and the note that it is archived, this solicitation is closed.
What types of organizations are eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, and many government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized tribal governments and other tribal entities, as well as tribal organizations, among eligible applicants.
Does the FOA encourage participation by specific categories of institutions?
The FOA explicitly notes eligibility categories such as HBCUs, Hispanic-serving institutions, tribal colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions.
Are faith-based or community-based organizations eligible to apply?
Yes. The FOA mentions faith-based or community-based organizations among eligible applicants.
Are federal government agencies eligible to apply?
Yes. The FOA includes eligible agencies of the federal government among eligible applicants.
Are foreign (non-U.S.) institutions eligible to apply?
No. Non-U.S. (foreign) institutions and non-domestic components of U.S. organizations are not eligible to apply under this FOA.
Are foreign components allowed in any form?
Yes. The FOA states that foreign components (as defined by NIH policy) are allowed, even though the applicant organization must be U.S.-based.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
Where can applicants find the official FOA details?
NIH provided an official FOA page at: http://grants.nih.gov/grants/guide/rfa_files/RFA-AI-14-055.html
Who should be contacted for technical access or linking issues related to the FOA page?
The FOA lists the NIH Office of Extramural Research (OER) Webmaster as the contact for technical access or linking issues: FBOWebmaster@OD.NIH.GOV.
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