Opportunity Information: Apply for RFA AT 10 002

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers of Excellence for Research on CAM (CERC) for Pain (P01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
  • This funding opportunity was created on Mar 18, 2010 and posted on Mar 18, 2010.
  • Applicants must submit their applications by Aug 13, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,750,000.00 to eligible and selected applicants.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments) County governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public housing authorities/Indian housing authorities.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Centers of Excellence for Research on CAM (CERC) for Pain (P01) funding opportunity (RFA-AT-10-002) was a National Institutes of Health grant announcement, administered through what was then NCCAM (now known as NCCIH), aimed at strengthening the evidence base for complementary, alternative, and integrative medicine (CAM/IM) approaches for chronic pain. The core idea was to move beyond isolated studies by supporting coordinated, center-style research programs that could answer the most important basic, mechanistic, and translational questions needed to understand how these interventions work, for whom they work best, and how to apply them optimally in real-world pain care. In practical terms, the FOA was designed to accelerate progress in chronic pain by encouraging multidisciplinary teams to investigate promising CAM/IM modalities in a rigorous, integrated way, tying together biological mechanisms, clinical outcomes, and translational pathways.

The award mechanism was the NIH P01 Program Project Grant, which is intended for complex, multi-project efforts that share a unifying theme and benefit from close scientific coordination. Under this FOA, applicants were expected to propose a “Center” composed of three or four synergistic projects, each comparable in scope and rigor to an R01-level project. The emphasis on synergy is important: the projects were meant to reinforce each other scientifically (for example, a mechanistic laboratory project informing biomarkers or hypotheses tested in a clinical/translational project), rather than functioning as separate, loosely related studies. The FOA specifically called for multidisciplinary research teams, which typically implies collaboration across relevant domains such as pain medicine, neuroscience, psychology, rehabilitation science, epidemiology, biostatistics, and CAM/IM-specific expertise, depending on the chosen interventions and research questions.

From a funding standpoint, NIH indicated that total funds awarded would depend on application quality, project duration, and budgets proposed, but it anticipated making up to three awards in fiscal year 2011. Each pain-focused CERC was expected to be funded at approximately $1.25 million per year, with an estimated total program funding level around $3.75 million. Cost sharing or matching was not required, which aligns with typical NIH research grant structures where the emphasis is on scientific merit and feasibility rather than applicant-provided matching funds.

Eligibility was broad and included many types of domestic organizations that commonly participate in federal biomedical research, including public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and certain non-501(c)(3) entities), small businesses, and for-profit organizations other than small businesses, as well as state, county, city/township, and special district governments. It also extended to tribal governments and tribally controlled institutions, public housing authorities/Indian housing authorities, and a number of specifically noted institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs), along with U.S. territories or possessions and certain eligible federal agencies. This wide eligibility reflects an intent to draw strong pain and CAM/IM research teams from across the research ecosystem, including community-based and faith-based organizations where appropriate, provided they could meet NIH expectations for research capability and oversight.

In terms of timing and status, the opportunity was posted on March 18, 2010, with an application closing date of August 13, 2010, and it was later archived (archive date September 13, 2010). The CFDA listing associated with the program was 93.213, labeled “Research and Training in Complementary and Integrative Health.” The official NIH announcement was accessible through the NIH grants guide (via the link provided in the source), and NIH offered standard technical contact support through the NIH Office of Extramural Research (OER) web team for applicants who had trouble accessing or linking to the full FOA text.

Overall, this FOA can be summed up as a targeted, center-based NIH investment in high-quality, coordinated research on CAM/IM interventions for chronic pain, structured around multiple interlocking R01-level projects under a P01 umbrella, with the goal of producing more definitive mechanistic and translational knowledge to guide the effective use of integrative approaches in pain management.

Frequently Asked Questions (FAQs)

What is the CERC for Pain (P01) funding opportunity (RFA-AT-10-002)?

It was a National Institutes of Health (NIH) funding opportunity titled Centers of Excellence for Research on CAM (CERC) for Pain (P01). It was administered through what was then NCCAM (now NCCIH) and focused on strengthening the evidence base for complementary, alternative, and integrative medicine (CAM/IM) approaches for chronic pain.

What was the main purpose of this FOA?

The goal was to accelerate progress in chronic pain research by supporting coordinated, center-style programs rather than isolated studies. The FOA emphasized rigorous, integrated investigation of promising CAM/IM modalities to answer key basic, mechanistic, and translational questions, including how interventions work, who benefits most, and how to apply them effectively in real-world pain care.

Which NIH institute or center administered the opportunity?

The announcement was administered through NCCAM, which is now known as the National Center for Complementary and Integrative Health (NCCIH).

What grant mechanism did this FOA use?

The award mechanism was the NIH P01 Program Project Grant, designed for complex, multi-project research efforts that share a unifying theme and benefit from close scientific coordination.

What did applicants have to propose under the P01 "Center" structure?

Applicants were expected to propose a Center composed of three or four synergistic projects. Each project was expected to be comparable in scope and rigor to an R01-level project.

What does "synergy" mean in the context of this FOA?

Synergy meant the projects were expected to reinforce each other scientifically rather than operate as separate, loosely connected studies. An example described in the opportunity was a mechanistic laboratory project informing biomarkers or hypotheses that would be tested in a clinical or translational project.

What kinds of research questions was the FOA trying to address?

It targeted major basic, mechanistic, and translational questions needed to understand CAM/IM interventions for chronic pain, including how they work biologically, for whom they work best, and how to apply them optimally in real-world pain care.

Was multidisciplinary collaboration expected?

Yes. The FOA specifically called for multidisciplinary research teams, commonly involving collaboration across domains such as pain medicine, neuroscience, psychology, rehabilitation science, epidemiology, biostatistics, and CAM/IM-specific expertise, depending on the intervention and research questions.

How many awards did NIH anticipate making?

NIH anticipated making up to three awards in fiscal year 2011, with the final number dependent on application quality, project duration, and proposed budgets.

What was the expected funding level per Center?

Each pain-focused CERC was expected to be funded at approximately $1.25 million per year.

What was the estimated total program funding level?

The estimated total program funding level was around $3.75 million (based on the expectation of up to three awards at approximately $1.25 million per year each).

Was cost sharing or matching required?

No. The FOA stated that cost sharing or matching was not required.

Who was eligible to apply?

Eligibility was broad and included many types of domestic organizations, such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, and for-profit organizations other than small businesses. Eligible applicants also included state, county, city/township, and special district governments, as well as tribal governments and tribally controlled institutions.

Did eligibility include specific institution categories like HBCUs and Tribal Colleges?

Yes. The FOA specifically noted eligibility for categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs), among others.

Were U.S. territories or possessions included in eligibility?

Yes. Eligibility extended to U.S. territories or possessions, as well as certain eligible federal agencies.

Could community-based or faith-based organizations apply?

The opportunity indicated wide eligibility and noted that community-based and faith-based organizations could be included where appropriate, provided they could meet NIH expectations for research capability and oversight.

When was the opportunity posted and when did it close?

It was posted on March 18, 2010, and the application closing date was August 13, 2010.

What is the archive date and what does it mean here?

The archive date listed was September 13, 2010. Based on the information provided, the opportunity was later archived after the submission period.

What CFDA number was associated with this program?

The CFDA listing associated with the program was 93.213, labeled "Research and Training in Complementary and Integrative Health."

Where could applicants find the official announcement?

The official NIH announcement was accessible through the NIH grants guide (via the link referenced in the source description of the opportunity).

What support was mentioned for technical issues accessing the FOA?

NIH offered standard technical contact support through the NIH Office of Extramural Research (OER) web team for applicants who had trouble accessing or linking to the full FOA text.

How can this FOA be summarized in plain terms?

It was a targeted NIH investment in coordinated, center-based research on CAM/IM interventions for chronic pain, built around multiple interlocking R01-level projects under a P01 umbrella, aimed at producing stronger mechanistic and translational evidence to guide integrative approaches in pain management.

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