Opportunity Information: Apply for PAR 14 195
Apply for PAR 14 195
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers of Excellence in Genomic Science (CEGS) (RM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research 93.242 Mental Health Research Grants.
- This funding opportunity was created on Apr 28, 2014 and posted on Apr 28, 2014.
- Applicants must submit their applications by May 20, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Centers of Excellence in Genomic Science (CEGS) (RM1) funding opportunity, issued by the National Institutes of Health (NIH) under PAR-14-195, is designed to establish and support academic Centers that push the frontiers of genome research. The core idea is to fund large, multi-investigator, interdisciplinary teams that can bring together expertise across areas like genomics, molecular biology, engineering, computation, statistics, and clinical research to tackle a clearly defined biomedical problem using genomic approaches. Rather than supporting incremental work, the program is meant for projects that take on a critical challenge in genomic science or genomic medicine and propose a solution that would represent a major leap forward.
A key feature of CEGS is its emphasis on high-risk, high-reward research. NIH expects these Centers to pursue ambitious directions that may be technically or conceptually challenging, where success would have an outsized impact. That risk is meant to be balanced by exceptionally strong scientific rationale, careful planning, and credible management structures, so the work is bold but not careless. The intended payoff is the creation of transformative methods, resources, or insights that can change what is possible in genomic research and, importantly, accelerate the translation of genomic knowledge into clinical application.
In terms of scientific scope, a CEGS can focus on developing novel technologies or computational methods for generating or analyzing comprehensive genomic-scale datasets, or it can center on a particular genome-scale biomedical problem where genomics is the driving approach. This includes, for example, new platforms or pipelines for measuring genomic information, advanced computational frameworks for integrating and interpreting large multi-omic datasets, or innovative strategies for using genomic data to understand biological systems and disease mechanisms. The program also explicitly values work that significantly advances the application of genomic data and methods toward clinical outcomes, meaning that successful projects should not just produce data, but should also improve how genomic information can be used to inform diagnosis, prognosis, prevention, or treatment.
Beyond the research itself, the CEGS program is structured to strengthen genomics capacity at the funded institution. Each Center is expected to act as a hub that promotes collaboration across disciplines, making it easier for investigators with different skill sets to interact, share tools, and jointly solve problems that no single lab could address alone. Training is also a central mission: CEGS Centers are expected to provide meaningful development opportunities for both new and established investigators, expanding the pipeline of highly trained genomics scientists and engineers who can sustain and grow the field over time.
Administratively, this opportunity is a discretionary NIH grant using the RM1 activity code. It falls under the Health funding activity category and is associated with CFDA numbers 93.172 (Human Genome Research) and 93.242 (Mental Health Research Grants). There is no cost-sharing or matching requirement. The opportunity was posted on April 28, 2014, with an original and current closing date of May 20, 2016, and an archive date of June 20, 2016.
Eligibility includes a range of U.S.-based organizations, including public and state-controlled institutions of higher education, private institutions of higher education, and certain nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified in the listing). The eligible applicant pool also explicitly includes several categories of institutions that serve specific communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible. Foreign components, as defined by NIH policy, are not allowed under this announcement.
For applicants looking for the full official announcement and requirements, NIH provided an additional information link at http://grants.nih.gov/grants/guide/pa-files/PAR-14-195.html. For technical issues accessing the announcement or problems with linking, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Centers of Excellence in Genomic Science (CEGS) (RM1) - FAQs
What is the CEGS (RM1) funding opportunity?
The Centers of Excellence in Genomic Science (CEGS) is an NIH funding opportunity (PAR-14-195) that supports the creation and operation of academic Centers focused on pushing the frontiers of genome research. It is intended to fund large, multi-investigator, interdisciplinary teams that use genomic approaches to tackle a clearly defined biomedical problem in a way that represents a major leap forward rather than incremental progress.
Which agency runs this program?
This opportunity is issued by the National Institutes of Health (NIH).
What is the activity code for this grant mechanism?
The activity code is RM1.
What kind of research is the program meant to support?
The program is designed for ambitious projects that address a critical challenge in genomic science or genomic medicine. NIH is looking for work where genomics is the driving approach and where the outcomes could be transformative, such as new methods, resources, or insights that materially change what is possible in genomic research and help accelerate translation into clinical application.
Is this opportunity intended for incremental research projects?
No. The CEGS program is explicitly positioned to avoid incremental work and instead support projects aiming for major leaps forward in genomic science or genomic medicine.
Does NIH encourage high-risk, high-reward approaches under CEGS?
Yes. A central feature of the program is an emphasis on high-risk, high-reward research, including directions that are technically or conceptually challenging. That risk is expected to be balanced by strong scientific rationale, careful planning, and credible management structures.
What are examples of scientific scope areas that a CEGS Center may cover?
Based on the description provided, a CEGS Center may focus on one or more of the following broad directions:
- Developing novel technologies for generating comprehensive genomic-scale datasets
- Developing computational methods for analyzing genomic-scale data
- Building advanced computational frameworks to integrate and interpret large multi-omic datasets
- Creating new platforms, pipelines, or strategies for measuring genomic information
- Addressing a genome-scale biomedical problem where genomics is the driving approach
- Using genomic data to better understand biological systems and disease mechanisms
How important is clinical translation in this program?
The program explicitly values research that significantly advances the application of genomic data and methods toward clinical outcomes. Successful projects are expected to do more than produce datasets; they should improve how genomic information can be used to inform diagnosis, prognosis, prevention, or treatment.
What types of expertise are expected to be included on a CEGS team?
The opportunity is designed for interdisciplinary teams and highlights bringing together expertise across areas such as genomics, molecular biology, engineering, computation, statistics, and clinical research.
What is the core organizational concept behind a CEGS Center?
A CEGS Center is expected to function as a hub that strengthens genomics capacity at the funded institution by promoting collaboration across disciplines, enabling investigators to share tools and work jointly on problems that are difficult or impossible for a single lab to solve alone.
Is training part of what CEGS Centers are expected to do?
Yes. Training is described as a central mission. Centers are expected to provide meaningful development opportunities for both new and established investigators to expand the pipeline of highly trained genomics scientists and engineers.
What is the funding activity category for this opportunity?
The opportunity falls under the Health funding activity category.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.172 (Human Genome Research) and CFDA 93.242 (Mental Health Research Grants).
Is there a cost-sharing or matching requirement?
No. The opportunity states there is no cost-sharing or matching requirement.
When was this opportunity posted?
The opportunity was posted on April 28, 2014.
What were the closing dates for this opportunity?
The original closing date and the current closing date listed are both May 20, 2016.
When was the opportunity archived?
The archive date listed is June 20, 2016.
Who is eligible to apply?
Eligibility includes a range of U.S.-based organizations, including public and state-controlled institutions of higher education, private institutions of higher education, and certain nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified in the listing).
Are institutions serving specific communities explicitly included in the eligible applicant pool?
Yes. The listing explicitly includes several categories of institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply under this announcement.
Are non-U.S. components of U.S. organizations allowed to apply?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under this announcement?
No. Foreign components, as defined by NIH policy, are not allowed under this announcement.
Where can applicants find the official NIH announcement and full requirements?
The official announcement and full details are available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-195.html
Who should be contacted for technical issues accessing the announcement or link problems?
For technical issues accessing the announcement or problems with linking, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the main expected payoff of a funded CEGS Center?
The intended payoff is the creation of transformative methods, resources, or insights that can change what is possible in genomic research and accelerate the translation of genomic knowledge into clinical application.
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