Opportunity Information: Apply for PAR 16 436
Apply for PAR 16 436
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers of Excellence in Genomic Science (CEGS) (RM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on Sep 19, 2016.
- Applicants must submit their applications by May 20, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,750,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Centers of Excellence in Genomic Science (CEGS) (RM1) grant opportunity (Funding Opportunity Number PAR 16-436) is a National Institutes of Health (NIH) program under the U.S. Department of Health and Human Services designed to establish and support academic Centers that push the boundaries of genome research. The core idea is to fund highly integrated, multi-investigator teams that bring together different disciplines (for example, genomics, engineering, computer science, statistics, molecular biology, and clinical expertise) to create or apply innovative genomic approaches to solve an important biomedical problem. Rather than supporting incremental work, the program is meant for projects that take on a critical challenge in genomic science or genomic medicine and propose a solution that would represent a major leap forward if successful.
A central feature of CEGS is its emphasis on high-risk, high-reward research. The projects are expected to tackle ambitious goals where the path is not fully proven, but the potential payoff is large enough to justify that risk. Because of this, strong scientific rationale alone is not sufficient; applications are expected to pair bold ideas with excellent planning, including clear management structures, well-thought-out milestones, and convincing strategies for coordinating complex, interdisciplinary work. The CEGS model is essentially a center-style effort, meaning it is built around collaborative science at scale rather than isolated individual projects.
In terms of scientific scope, CEGS Centers can focus on developing new technologies or computational methods for generating and analyzing comprehensive genomic datasets, addressing specific genome-scale biomedical questions, or creating other novel ways to use genomics to understand biological systems. This can include work that improves how genomic data are produced (such as advanced sequencing or measurement approaches), how they are processed and interpreted (such as new algorithms, statistical models, or machine learning methods), or how genomic knowledge and tools are translated toward clinical applications. The program language explicitly supports both technology/method development and genome-scale problem solving, as long as the proposed work advances the field in a substantial way and leverages genomic approaches as a central engine of discovery.
Beyond the research aims, each funded Center is expected to strengthen genomics at its home institution by acting as a hub that brings investigators from different fields into sustained interaction. Training is also a key expectation: CEGS Centers are intended to develop talent by providing opportunities for both new and experienced investigators to gain skills in modern genomics and its enabling disciplines. In this way, the program is not only funding a set of research outcomes, but also building long-term capacity by expanding the pool of highly qualified genomics scientists and engineers.
Administratively, this is a discretionary grant opportunity in the health funding activity category (CFDA 93.172). Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), with additional eligibility details referenced in the full announcement. The opportunity was created on September 19, 2016, with an original closing date of May 20, 2019. The listed award ceiling is $1,750,000, and the opportunity anticipated making about two awards, indicating a competitive program aimed at funding a small number of exceptionally strong, center-scale efforts.
Overall, CEGS (RM1) is best understood as NIH support for a concentrated, interdisciplinary genomics center that pursues a big, difficult problem or enabling breakthrough, produces broadly useful methods or insights, and leaves behind stronger institutional and workforce capabilities in genomic science and genomic medicine.
Frequently Asked Questions (FAQs): Centers of Excellence in Genomic Science (CEGS) (RM1) - PAR 16-436
What is the CEGS (RM1) grant opportunity?
The Centers of Excellence in Genomic Science (CEGS) (RM1) program (Funding Opportunity Number PAR 16-436) is a National Institutes of Health (NIH) grant opportunity under the U.S. Department of Health and Human Services that supports academic center-style teams working at the leading edge of genome research.
What is the main purpose of the CEGS program?
The program is designed to establish and support highly integrated, multi-investigator Centers that push the boundaries of genomic science by creating or applying innovative genomic approaches to solve an important biomedical problem. It is intended for efforts that would represent a major leap forward if successful.
What kind of projects is CEGS intended to fund?
CEGS is meant for ambitious, center-scale projects that tackle a critical challenge in genomic science or genomic medicine. The focus is on non-incremental work: projects should aim for significant advances rather than small, stepwise improvements.
What does "high-risk, high-reward" mean in this program?
CEGS emphasizes high-risk, high-reward research where the approach may not be fully proven, but the potential payoff is large enough to justify the risk. Applicants are expected to pursue bold goals while also presenting strong planning and coordination strategies appropriate for complex interdisciplinary work.
Is strong scientific rationale enough to be competitive?
No. In addition to a compelling scientific rationale, applications are expected to include excellent planning, including clear management structures, well-defined milestones, and convincing strategies for coordinating a complex, interdisciplinary Center.
What is meant by a "center-style" effort in the CEGS model?
The CEGS model is built around collaborative science at scale. Rather than isolated projects led by a single investigator, the program supports multi-investigator teams working in an integrated way across disciplines to achieve shared goals.
What disciplines are expected to be involved in a CEGS Center?
The program emphasizes interdisciplinary teams and explicitly highlights combining areas such as genomics, engineering, computer science, statistics, molecular biology, and clinical expertise, among others.
What is the scientific scope of CEGS Centers?
CEGS Centers can focus on developing new technologies or computational methods for generating and analyzing comprehensive genomic datasets, addressing specific genome-scale biomedical questions, or creating other novel ways to apply genomics to understand biological systems.
Can a CEGS project focus on technology or method development?
Yes. The program explicitly supports technology and method development, such as improved sequencing or measurement approaches, new algorithms, statistical models, or machine learning methods, as long as genomics is central and the proposed work substantially advances the field.
Can a CEGS project focus on solving a genome-scale biomedical problem?
Yes. CEGS supports genome-scale problem solving, including addressing specific biomedical questions using genomic approaches, provided the work aims for a substantial advance and is positioned as a major leap forward if successful.
What types of genomic advances are specifically encouraged?
The scope includes improvements in how genomic data are produced (for example, advanced sequencing or measurement approaches), processed and interpreted (for example, new algorithms, statistical models, or machine learning), and translated toward clinical applications.
Does the program support translation toward clinical applications?
Yes. The opportunity language supports work that translates genomic knowledge and tools toward clinical applications, as part of advancing genomic science and genomic medicine.
What are the expectations beyond research aims?
Beyond research outcomes, each funded Center is expected to strengthen genomics at its home institution by acting as a hub that brings investigators from different fields into sustained interaction.
Is training a required or expected part of a CEGS Center?
Training is a key expectation. CEGS Centers are intended to develop talent by providing opportunities for both new and experienced investigators to gain skills in modern genomics and enabling disciplines.
How does CEGS build long-term capacity?
The program is intended to build long-term capacity by strengthening institutional genomics efforts and expanding the pool of highly qualified genomics scientists and engineers through sustained interdisciplinary collaboration and training opportunities.
Which federal agency runs this opportunity?
This is an NIH program under the U.S. Department of Health and Human Services.
What is the funding opportunity number?
The funding opportunity number is PAR 16-436.
What grant mechanism is used for CEGS?
The opportunity is described as CEGS (RM1), indicating an RM1 mechanism for supporting the Center-style, integrated effort.
What is the funding activity category and CFDA listing?
The opportunity is listed under the health funding activity category and includes CFDA 93.172.
What type of grant opportunity is this?
It is described as a discretionary grant opportunity.
Who is eligible to apply?
Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations, including both 501(c)(3) and non-501(c)(3) entities. Additional eligibility details are referenced in the full announcement.
When was this opportunity created and when did it close?
The opportunity was created on September 19, 2016, and the original closing date was May 20, 2019.
What is the award ceiling for this opportunity?
The listed award ceiling is $1,750,000.
How many awards were anticipated?
The opportunity anticipated making about two awards, suggesting a highly competitive program designed to fund a small number of exceptionally strong Center-scale projects.
What makes an application a good fit for CEGS based on the program description?
A good fit is a highly integrated, interdisciplinary, center-style proposal that uses genomics as a central engine of discovery, targets a critical challenge in genomic science or medicine, pursues a high-risk/high-reward leap forward, and includes strong management, milestones, and coordination plans, along with institutional hub-building and training components.
What outcomes is CEGS intended to leave behind?
In addition to research advances and broadly useful methods or insights, the program aims to leave behind stronger institutional capabilities in genomics and a better-trained workforce in genomic science and genomic medicine.
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