Opportunity Information: Apply for RFA AR 16 001
Apply for RFA AR 16 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers of Research Translation (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
- This funding opportunity was created on Aug 12, 2015 and posted on Aug 12, 2015.
- Applicants must submit their applications by Dec 11, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Private institutions of higher education Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) County governments City or township governments Small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Centers of Research Translation (CORT) (P50) opportunity (RFA-AR-16-001) is a National Institutes of Health program administered through NIAMS (the National Institute of Arthritis and Musculoskeletal and Skin Diseases) designed to fund team-based, translational research centers focused on diseases and conditions within the NIAMS mission area. The intent is to bring together a synergistic group of investigators to tackle a major translational challenge that is too complex for a single lab or a standard single-project grant, and to push discoveries toward tangible clinical impact. A successful CORT is expected to generate new knowledge about human pathophysiology and to advance practical outputs such as new therapeutic targets, diagnostics, prevention approaches, or other clear deliverables that move the field closer to better patient care.
The FOA allows two general structural models. In one model, the center is organized around a disease-targeted translational theme that is addressed through multiple, synergistic translational Research Projects, with Research Cores included as needed to support and integrate the work. In the second model, the center is built around one major collaborative translational Research Project that is enabled by several highly interactive Research Cores; in that approach, the cores are not merely service units, but are deeply integrated and evolve over time alongside the main project as it is developed and implemented. In both cases, the key idea is that the projects and cores collectively create more scientific and translational value than the components could produce on their own.
In terms of required components, each CORT application must include at least three highly meritorious research components total, made up of one or more translational Research Projects and one or more Research Cores. An Administrative Core is mandatory for every application and is expected to provide overall governance, coordination, communication, and operational support to keep the center functioning as a coherent team science enterprise. The program is explicitly designed to promote team science, so the lead investigators across the research components are expected to represent relevant and, when appropriate, different disciplines, and they may come from different departments, divisions, and even different institutions. This multi-investigator, cross-disciplinary setup is central to the CORT concept because translational problems in NIAMS-relevant diseases often require coordinated expertise spanning basic biology, preclinical modeling, clinical research, biostatistics, imaging, omics, informatics, and other specialized capabilities.
From a funding and administrative standpoint, this is a discretionary grant mechanism (P50 center grant) in the NIH health research category. NIAMS anticipated making about 4 awards under this announcement, with an estimated total program funding level of about $6,000,000. The listed award ceiling is $1,000,000. There is no cost-sharing or matching requirement. The opportunity was posted on August 12, 2015, with an original and current closing date of December 11, 2015, and an archive date of January 11, 2016, meaning it is a past/archived solicitation rather than an active one.
Eligibility is broad across U.S.-based organizations and government entities and includes public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) nonprofits), small businesses, for-profit organizations other than small businesses, independent school districts, and various levels of government (city/township, county, state, special district, and certain housing authorities). It also includes tribal governments and tribal organizations, as well as a range of mission-focused institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions, among others. Foreign institutions and non-U.S. organizational components are not eligible to apply directly; however, foreign components (as defined by NIH policy) may be allowed within an otherwise eligible application.
Overall, the CORT (P50) program is best viewed as a center-level investment in translational research where success depends on strong scientific integration, clear translational aims, and a well-structured set of projects and cores that work together to produce clinically meaningful advances in arthritis, musculoskeletal, and skin disease research areas aligned with NIAMS priorities.
Centers of Research Translation (CORT) (P50) - FAQs
What is the CORT (P50) funding opportunity (RFA-AR-16-001)?
The Centers of Research Translation (CORT) (P50) opportunity (RFA-AR-16-001) is a National Institutes of Health (NIH) program administered through NIAMS (the National Institute of Arthritis and Musculoskeletal and Skin Diseases). It is designed to fund team-based, translational research centers focused on diseases and conditions within the NIAMS mission area.
What is the main purpose of a CORT?
The purpose is to bring together a synergistic group of investigators to tackle a major translational challenge that is too complex for a single lab or a standard single-project grant. The goal is to push discoveries toward tangible clinical impact, including generating new knowledge about human pathophysiology and advancing practical deliverables that move the field closer to better patient care.
What kinds of outputs or deliverables are expected from a successful CORT?
A successful CORT is expected to advance practical outputs such as new therapeutic targets, diagnostics, prevention approaches, or other clear deliverables tied to clinically meaningful advances, in addition to generating new knowledge about human pathophysiology.
What grant mechanism is used for this program?
This opportunity uses the P50 center grant mechanism and is described as a discretionary grant mechanism in the NIH health research category.
How is a CORT center allowed to be structured?
The FOA allows two general structural models:
- Model 1: A disease-targeted translational theme addressed through multiple synergistic translational Research Projects, with Research Cores included as needed to support and integrate the work.
- Model 2: One major collaborative translational Research Project enabled by several highly interactive Research Cores. In this model, the cores are deeply integrated (not merely service units) and are expected to evolve over time alongside the main project.
What is the key concept behind combining projects and cores in a CORT?
The central idea is that the projects and cores should collectively create more scientific and translational value than the components could produce on their own. Scientific integration and synergy are core expectations.
What are the required components of a CORT application?
Each CORT application must include at least three highly meritorious research components total, made up of one or more translational Research Projects and one or more Research Cores. An Administrative Core is mandatory for every application.
Is an Administrative Core required, and what does it do?
Yes. An Administrative Core is mandatory and is expected to provide overall governance, coordination, communication, and operational support to keep the center functioning as a coherent team science enterprise.
Are Research Cores optional or required?
The FOA requires at least three research components total consisting of Research Projects and/or Research Cores. Research Cores can be included as needed to support and integrate work, and under the second model, several highly interactive cores enable one major collaborative project.
In the second structural model, are cores just service units?
No. In the model built around one major collaborative translational Research Project, the Research Cores are expected to be highly interactive, deeply integrated, and to evolve over time alongside the main project as it is developed and implemented.
What kind of research emphasis does the CORT program have?
The program emphasizes translational research and team science aimed at NIAMS-relevant diseases and conditions, with a focus on moving discoveries toward tangible clinical impact.
Does the program encourage team science and cross-disciplinary collaboration?
Yes. The program is explicitly designed to promote team science. Lead investigators across research components are expected to represent relevant and, when appropriate, different disciplines, and may come from different departments, divisions, and even different institutions.
Can multiple institutions participate in a single application?
Yes. The FOA states that investigators may come from different institutions, reflecting the expectation for multi-investigator and cross-disciplinary collaboration when appropriate.
What types of expertise might be involved in a CORT?
The opportunity notes that translational problems may require coordinated expertise spanning areas such as basic biology, preclinical modeling, clinical research, biostatistics, imaging, omics, informatics, and other specialized capabilities.
How many awards were anticipated and what was the overall funding level?
NIAMS anticipated making about 4 awards under this announcement, with an estimated total program funding level of about $6,000,000.
What is the listed award ceiling?
The listed award ceiling is $1,000,000.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement stated for this opportunity.
When was this opportunity posted and when did it close?
The opportunity was posted on August 12, 2015. The original and current closing date listed is December 11, 2015, and the archive date is January 11, 2016.
Is this an active funding opportunity?
No. Based on the listed closing and archive dates, it is a past/archived solicitation rather than an active one.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) nonprofits), small businesses, for-profit organizations other than small businesses, independent school districts, and various levels of government (including city/township, county, state, special district, and certain housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list includes tribal governments and tribal organizations.
Are mission-focused institution types included in eligibility?
Yes. The eligibility description includes institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions, among others.
Can foreign institutions apply directly?
No. Foreign institutions and non-U.S. organizational components are not eligible to apply directly under this opportunity.
Are foreign components allowed in any way?
Yes. The FOA indicates that foreign components (as defined by NIH policy) may be allowed within an otherwise eligible application.
What NIAMS research areas does the program align with?
The program is aligned with NIAMS priorities and focuses on arthritis, musculoskeletal, and skin disease research areas within the NIAMS mission area.
How should applicants think about what makes a strong CORT concept?
The opportunity frames CORT as a center-level investment where success depends on strong scientific integration, clear translational aims, and a well-structured set of projects and cores that work together to produce clinically meaningful advances.
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