Opportunity Information: Apply for RFA NS 11 007

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers without Walls for Collaborative Research in the Epilepsies Genetics and Genomics of Human Epilepsies (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
  • This funding opportunity was created on Nov 23, 2010 and posted on Nov 23, 2010.
  • Applicants must submit their applications by Mar 11, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Small businesses Public and State controlled institutions of higher education For profit organizations other than small businesses County governments Public housing authorities/Indian housing authorities State governments Special district governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The funding opportunity titled "Centers without Walls for Collaborative Research in the Epilepsies: Genetics and Genomics of Human Epilepsies (U01)" (Funding Opportunity Number RFA-NS-11-007) is a National Institutes of Health (NIH) cooperative agreement program designed to push epilepsy genetics research forward faster by supporting a large, highly collaborative, multidisciplinary team rather than isolated individual projects. The core aim is to accelerate discovery of genetic factors that contribute to epilepsy syndromes, with an emphasis on coordinated, team-based science that can tackle complex genetic and genomic questions more effectively than any single lab working alone. The "Centers without Walls" concept signals that the center is not meant to be confined to a single institution or location; instead, it is structured to connect investigators across sites into a unified, tightly managed research effort.

This program uses the U01 cooperative agreement mechanism, meaning the funded work is intended to be carried out in partnership with NIH program staff, with an expectation of active scientific involvement and coordination beyond what is typical in a standard research grant. Applicants are encouraged to submit linked applications that collectively form a center-like structure. Those linked components may include an administrative core to manage and coordinate the collaboration, a genetics core to provide centralized expertise and infrastructure for genetic and genomic work, and multiple individual scientific projects proposed for the initial performance period. Taken together, these components are meant to function as an integrated research enterprise, aligning shared resources, harmonized methods, and collective goals to speed progress in gene discovery and related genomic analyses in human epilepsies.

In terms of scope and scale, NIH anticipated making a single award under this announcement, indicating a competitive process aimed at selecting one particularly strong, comprehensive consortium. The estimated total funding level listed for the opportunity is $3,000,000, and there is no cost sharing or matching requirement, which reduces barriers for applicants who might otherwise need to commit institutional funds. The program is categorized under the health activity area and is associated with CFDA number 93.853, which corresponds to Extramural Research Programs in the Neurosciences and Neurological Disorders.

Eligibility is broad and includes many types of organizations that could realistically participate in a complex, multi-institution research collaboration. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, for-profit entities other than small businesses, and various levels of government entities such as state, county, city/township governments, special district governments, independent school districts, and public housing/Indian housing authorities. The eligibility language also explicitly encompasses a wide range of mission-driven institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal organizations and tribal governments (including federally recognized tribes), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and even non-U.S. (foreign) entities. Practically, this breadth supports the idea of a distributed "center without walls," where specialized expertise, patient cohorts, data resources, and analytic capabilities may be spread across many settings.

Key administrative details place the announcement in a specific historical funding cycle. It was posted and created on November 23, 2010, with an original and current closing date of March 11, 2011, and an archive date of April 11, 2011. The funding instrument is explicitly listed as a cooperative agreement, and the opportunity category is discretionary. The NIH listing provides an additional information link to the archived NIH Grants Guide page for the full announcement text, which would contain the detailed scientific expectations, application structure requirements for linked submissions, review criteria, and any program-specific requirements around collaboration, data sharing, governance, or milestones. For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), indicating that questions about accessing or linking to the announcement were directed to NIH OER support.

Overall, this FOA is best understood as NIH support for a single, highly organized, cooperative, multi-project consortium focused on human epilepsy genetics and genomics, built around shared cores and coordinated projects, with the explicit goal of speeding the identification of genetic contributors to epilepsy syndromes through large-scale collaboration.

Frequently Asked Questions (FAQs)

What is the title of this funding opportunity?

The opportunity is titled "Centers without Walls for Collaborative Research in the Epilepsies: Genetics and Genomics of Human Epilepsies (U01)."

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is RFA-NS-11-007.

Which federal agency is offering this opportunity?

This opportunity is offered by the National Institutes of Health (NIH).

What kind of grant mechanism is used (and what does U01 mean here)?

The program uses the U01 cooperative agreement mechanism. In this structure, the funded work is expected to be conducted in partnership with NIH program staff, with active scientific involvement and coordination beyond what is typical for a standard research grant.

What is the main purpose of this program?

The core aim is to accelerate discovery of genetic factors that contribute to epilepsy syndromes by supporting a large, highly collaborative, multidisciplinary team rather than isolated individual projects.

What does "Centers without Walls" mean in this announcement?

"Centers without Walls" indicates the center is not intended to be confined to a single institution or location. Instead, it is designed to connect investigators across sites into a unified, tightly managed research effort.

What scientific area does the program focus on?

The focus is on genetics and genomics of human epilepsies, with emphasis on coordinated, team-based science to address complex genetic and genomic questions.

How is the collaboration expected to be organized?

Applicants are encouraged to submit linked applications that collectively form a center-like structure, aligning shared resources, harmonized methods, and collective goals to speed progress in gene discovery and related genomic analyses.

What kinds of components may be included in linked applications?

Linked components may include an administrative core to manage and coordinate collaboration, a genetics core to provide centralized expertise and infrastructure for genetic and genomic work, and multiple individual scientific projects proposed for the initial performance period.

How many awards did NIH anticipate making?

NIH anticipated making a single award under this announcement.

What is the estimated total funding level for the opportunity?

The estimated total funding level listed is $3,000,000.

Is cost sharing or matching required?

No. The announcement states there is no cost sharing or matching requirement.

What is the funding instrument and opportunity category?

The funding instrument is a cooperative agreement, and the opportunity category is discretionary.

What CFDA number is associated with this opportunity?

The opportunity is associated with CFDA number 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).

What activity area is this opportunity categorized under?

It is categorized under the health activity area.

Who is eligible to apply?

Eligibility is broad and includes: public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); small businesses; for-profit entities other than small businesses; and many government entities (state, county, city/township, special district governments, independent school districts, and public housing/Indian housing authorities).

Are specific institution types explicitly included (such as minority-serving institutions or tribal entities)?

Yes. The eligibility language explicitly includes HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal organizations and tribal governments (including federally recognized tribes), and faith-based or community-based organizations.

Are U.S. territories and regional organizations eligible?

Yes. The eligibility list includes U.S. territories or possessions and regional organizations.

Are federal agencies eligible to apply?

Yes. Eligible federal agencies are included in the eligibility language provided.

Are non-U.S. (foreign) entities eligible to apply?

Yes. The eligibility language explicitly includes non-U.S. (foreign) entities.

When was this opportunity posted and created?

It was posted and created on November 23, 2010.

What was the application closing date?

The original and current closing date listed is March 11, 2011.

When was the opportunity archived?

The archive date listed is April 11, 2011.

Where can applicants find the full announcement text?

The NIH listing references an additional information link to the archived NIH Grants Guide page, which contains the full announcement text and details such as scientific expectations, linked submission requirements, review criteria, and any program-specific requirements.

Who should be contacted for access or technical issues related to the announcement listing?

The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

What is the overall intent of this FOA in practical terms?

The FOA is intended to support a single, highly organized, cooperative, multi-project consortium focused on human epilepsy genetics and genomics, built around shared cores and coordinated projects to speed identification of genetic contributors to epilepsy syndromes through large-scale collaboration.

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