Opportunity Information: Apply for RFA DA 09 017
Apply for RFA DA 09 017
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Dec 8, 2008 and posted on Dec 8, 2008.
- Applicants must submit their applications by Jan 28, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,375,000.00 to eligible and selected applicants.
- Eligible applicants include: County governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Small businesses For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Independent school districts Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R01)" (Funding Opportunity Number RFA-DA-09-017) is a National Institutes of Health research funding announcement led jointly by the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (NINDS). Its central goal is to fund research that explains how chronic pain alters the central nervous system (CNS) and how those pain-related brain and spinal cord changes overlap with, resemble, or differ from the CNS changes seen in drug addiction. The announcement is framed as a Request for Applications (RFA), meaning it is a targeted call for research proposals in a specific scientific area rather than an open-ended investigator-initiated topic.
Scientifically, the opportunity is focused on mapping and understanding CNS adaptations across three closely connected domains: chronic pain, analgesia, and substance abuse. A major emphasis is on identifying what chronic pain does to the CNS over time, including how persistent pain states can reshape neural circuits, signaling pathways, and neurobiological processes. The FOA also highlights interest in how analgesic drugs from different classes affect these pain-induced CNS changes, which can include both therapeutic normalization and unintended neuroadaptations. In addition, it explicitly calls for research on what happens when analgesics are used in the absence of pain, which is important because some analgesics have abuse potential and may drive addiction-related CNS changes even without a pain condition present.
A key feature of this initiative is the comparative approach. Applicants are encouraged to directly compare and contrast CNS changes associated with chronic pain versus those associated with addiction, with the aim of teasing apart shared mechanisms (for example, overlapping reward, stress, learning, and motivation circuitry changes) versus unique mechanisms that may distinguish pain pathology from substance use pathology. This comparison is intended to clarify why chronic pain and addiction can become intertwined in real-world clinical settings, and to support the development of better interventions that treat pain effectively while reducing risk for misuse, dependence, and addiction. The FOA also underscores the importance of timing, encouraging studies that look at the temporal course of neurobiological changes, such as which adaptations occur early versus late, which persist after pain resolution or drug discontinuation, and which might predict future vulnerability.
Another specific interest area is the role of influencing factors that can shape CNS responses, including environmental and genetic contributors. This includes the idea that different individuals or populations may show different neurobiological trajectories depending on genetic background, exposures, stressors, context, or other environmental conditions. Projects that can explain variability in vulnerability and resilience across pain, analgesia response, and abuse risk align well with the goals of the announcement.
In terms of funding mechanism, this FOA uses the NIH R01 grant mechanism, which is the standard research project grant intended for more mature, substantial projects with a clear plan and strong preliminary rationale. The R01 announcement is described as running in parallel with two companion FOAs of identical scientific scope that use smaller mechanisms: an R21 (RFA-DA-09-018) for exploratory or developmental work, and an R03 (RFA-DA-09-019) for small research projects. Together, these parallel options allow investigators to propose work that matches the stage and scale of their research program while staying within the same scientific theme.
Administratively, the opportunity falls under the NIH and is categorized as a discretionary grant. The activity category is listed under Education and Health, and it is associated with CFDA numbers 93.279 (Drug Abuse and Addiction Research Programs) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The announcement states that there is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of the award. The posting and creation date are both December 8, 2008, with an original and current closing date of January 28, 2009, and an archive date of February 28, 2009. The estimated total funding amount listed for the program is $2,375,000.
Eligibility is broad and includes a wide range of organization types, reflecting NIH norms for biomedical research funding. Eligible applicants include state and local governments (including counties, cities, townships, special districts, and independent school districts), public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), small businesses, and for-profit organizations (including those other than small businesses). The eligibility section also notes additional eligible entities such as federally recognized and other tribal governments and organizations, Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign (non-U.S.) entities.
For applicants seeking the full official details, the funding announcement points to the NIH Grants Guide page for RFA-DA-09-017, and provides NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking issues. Overall, this R01 opportunity is designed to push forward mechanistic neuroscience that connects chronic pain biology with addiction biology, with a practical long-term aim of improving pain treatment while addressing or preventing addiction-related risks.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Central Nervous System Intersections of Drug Addiction, Chronic Pain and Analgesia (R01)." The Funding Opportunity Number (FON) is RFA-DA-09-017.
Which agencies are leading this funding announcement?
This is a National Institutes of Health (NIH) funding announcement led jointly by the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (NINDS).
What is the main purpose of this grant opportunity?
The main goal is to fund research that explains how chronic pain alters the central nervous system (CNS) and how those pain-related changes overlap with, resemble, or differ from CNS changes seen in drug addiction.
Is this an open-ended NIH opportunity or a targeted solicitation?
It is a Request for Applications (RFA), meaning it is a targeted call for research proposals in a specific scientific area (rather than an open-ended, investigator-initiated topic).
What scientific areas does the FOA emphasize?
The FOA emphasizes CNS adaptations across three connected domains: chronic pain, analgesia, and substance abuse. It focuses on how persistent pain reshapes neural circuits, signaling pathways, and neurobiological processes, and how these changes relate to addiction-associated CNS changes.
What types of CNS changes in chronic pain are of interest?
The announcement highlights interest in understanding how chronic pain alters the brain and spinal cord over time, including changes in neural circuits, signaling pathways, and broader neurobiological processes that develop with persistent pain states.
Does the FOA encourage research on analgesic drugs?
Yes. It highlights interest in how analgesic drugs from different classes affect pain-induced CNS changes, including both therapeutic effects (such as normalization of pain-related adaptations) and unintended neuroadaptations.
Does the FOA include interest in analgesic use when no pain condition is present?
Yes. It explicitly calls for research on what happens when analgesics are used in the absence of pain, noting the importance of this topic given that some analgesics have abuse potential and may drive addiction-related CNS changes even without pain.
What does the FOA mean by a comparative approach?
Applicants are encouraged to directly compare and contrast CNS changes associated with chronic pain versus those associated with addiction. The intent is to identify shared mechanisms (for example, overlapping reward, stress, learning, and motivation circuitry changes) as well as mechanisms unique to either pain pathology or substance use pathology.
Why is the overlap between chronic pain and addiction a focus?
The FOA frames this comparison as a way to clarify why chronic pain and addiction can become intertwined in clinical settings and to support development of interventions that treat pain effectively while reducing risk for misuse, dependence, and addiction.
Does the opportunity emphasize timing or the progression of neurobiological changes?
Yes. It underscores the importance of timing and encourages studies on the temporal course of neurobiological changes, such as which adaptations occur early versus late, which persist after pain resolution or drug discontinuation, and which might predict future vulnerability.
Are genetic and environmental factors within the scope of this announcement?
Yes. The FOA notes interest in influencing factors that shape CNS responses, including environmental and genetic contributors, and supports research that explains variability in vulnerability and resilience across pain, analgesia response, and abuse risk.
What funding mechanism is being used?
This FOA uses the NIH R01 mechanism, which is the standard research project grant intended for more mature, substantial projects with a clear plan and strong preliminary rationale.
Are there companion opportunities related to this R01?
Yes. The R01 runs in parallel with two companion FOAs of identical scientific scope that use smaller mechanisms: an R21 (RFA-DA-09-018) for exploratory or developmental work, and an R03 (RFA-DA-09-019) for small research projects.
What is the estimated total funding amount for the program?
The estimated total funding amount listed is $2,375,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What type of grant is this categorized as?
It is an NIH discretionary grant. The activity category is listed under Education and Health.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.279 (Drug Abuse and Addiction Research Programs) and CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
When was this opportunity posted?
The posting and creation date are both December 8, 2008.
What are the closing and archive dates for this opportunity?
The original and current closing date is January 28, 2009, and the archive date is February 28, 2009.
Who is eligible to apply?
Eligibility is broad and includes state and local governments (including counties, cities, townships, special districts, and independent school districts), public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education), small businesses, and for-profit organizations (including those other than small businesses).
Are tribal organizations and U.S. territories included in eligible applicants?
Yes. The eligibility list includes federally recognized and other tribal governments and organizations, as well as U.S. territories or possessions.
Are specific minority-serving institutions mentioned as eligible?
Yes. The eligibility section references Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included in the eligibility section.
Are federal agencies eligible to apply?
Yes. The eligibility section includes eligible federal agencies.
Are non-U.S. (foreign) entities eligible to apply?
Yes. Foreign (non-U.S.) entities are explicitly included as eligible applicants.
Where can applicants find the official full announcement?
The announcement points to the NIH Grants Guide page for RFA-DA-09-017 for full official details.
Who should be contacted for access or technical linking issues related to the announcement?
The opportunity provides NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking issues.
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