Opportunity Information: Apply for RFA HL 09 010
Apply for RFA HL 09 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Characterizing the Blood Stem Cell Niche (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Oct 17, 2008 and posted on Oct 17, 2008.
- Applicants must submit their applications by Jan 6, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $12,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses Private institutions of higher education Special district governments For profit organizations other than small businesses County governments Independent school districts Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH) offered this funding opportunity, titled "Characterizing the Blood Stem Cell Niche (R01)," to support focused research on the hematopoietic (blood-forming) stem cell niche. The central goal was to deepen understanding of the local tissue environment that regulates blood stem cells, which is considered essential for moving stem cell biology forward and improving real-world cellular therapies, especially hematopoietic stem cell transplantation. In practice, the opportunity aimed to push the field beyond broad descriptions of bone marrow microenvironments and toward clearer, experimentally supported explanations of which niche cells and molecular signals actually control stem cell maintenance, behavior, and successful engraftment.
A major emphasis of the announcement was encouraging collaborative, insight-driven projects that can dissect the niche into its functional parts. Applicants were expected to propose approaches that identify and test the roles of specific cellular components (for example, distinct stromal, vascular, or lineage-defined support cells) and the factors they produce that influence stem cell quiescence, self-renewal, differentiation, homing, and long-term repopulating capacity. The FOA highlighted two enabling capabilities as particularly integral: first, development and use of conditional genetic knockout models that allow investigators to remove or alter specific genes in specific cell lineages to prove causal roles in niche function; and second, use of imaging technologies that make it possible to observe or track stem cell engraftment and behavior within the niche in vivo. Together, these priorities point to an expectation for mechanistic work, not just descriptive profiling, and for experiments that can link molecular and cellular changes to measurable stem cell outcomes in a living system.
The mechanism of support was the NIH Research Project Grant (R01), which is the standard investigator-initiated award used to fund mature, hypothesis-driven biomedical research programs. Under this FOA, NHLBI indicated it planned to commit up to $3.0 million in fiscal year 2009, with an anticipated 5 to 8 awards for projects judged meritorious and responsive to the announcement. As with typical NIH language, funding was contingent on the availability of appropriations and on receiving a sufficient number of high-quality applications that fit the FOA's scope. The opportunity was categorized as discretionary, used the grant funding instrument type, and fell under the health funding activity category. The associated CFDA number listed was 93.839, Blood Diseases and Resources Research, and the FOA stated there was no cost sharing or matching requirement.
Eligibility was broad and included many organizational types across the public, nonprofit, and private sectors. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), small businesses, and for-profit organizations other than small businesses. Governmental entities were also eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement also explicitly included a range of mission- and population-focused institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and tribal governments and tribal organizations (both federally recognized and other than federally recognized). U.S. territories or possessions and regional organizations were also noted, along with eligible federal agencies, and faith-based or community-based organizations.
Administrative details place this as a time-limited solicitation from the 2008-2009 cycle. The opportunity (Funding Opportunity Number RFA-HL-09-010) was posted and created on October 17, 2008, with an original and current closing date of January 6, 2009, and an archive date of February 6, 2009. The estimate of total funding shown in the source data was $12,000,000, which reflects a broader estimate across the life of awards rather than only the FY2009 commitment amount described in the narrative. For full details, the announcement referenced the NIH Grants Guide page for the RFA, and provided contact information through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Characterizing the Blood Stem Cell Niche (R01)."
Which agency and institute offered this opportunity?
This opportunity was offered by the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH).
What is the main scientific focus of the opportunity?
The focus is on the hematopoietic (blood-forming) stem cell niche, specifically the local tissue environment that regulates blood stem cell maintenance and behavior.
What is the central goal of the research supported by this FOA?
The central goal is to deepen understanding of how the local tissue environment controls blood stem cells, with the intent of advancing stem cell biology and improving real-world cellular therapies, particularly hematopoietic stem cell transplantation.
What kind of progress did the FOA aim to drive in the field?
The FOA aimed to move the field beyond broad, descriptive accounts of bone marrow microenvironments and toward clearer, experimentally supported, mechanistic explanations of which niche cells and molecular signals control stem cell maintenance, behavior, and successful engraftment.
What type of projects were encouraged?
The announcement emphasized collaborative, insight-driven projects designed to dissect the niche into functional components and test the roles of specific niche elements.
What kinds of niche components were applicants expected to investigate?
Applicants were expected to identify and test specific cellular components of the niche, such as distinct stromal cells, vascular cells, or other lineage-defined support cells, along with the factors these cells produce that influence hematopoietic stem cell function.
Which stem cell behaviors and outcomes were highlighted as important to study?
The FOA highlighted studying how niche cells and signals influence stem cell quiescence, self-renewal, differentiation, homing, long-term repopulating capacity, and successful engraftment.
Did the FOA prioritize mechanistic studies over descriptive profiling?
Yes. The priorities indicated an expectation for mechanistic work that links molecular and cellular changes to measurable stem cell outcomes in a living system, rather than studies limited to descriptive profiling.
What enabling capabilities were specifically emphasized in the FOA?
Two enabling capabilities were highlighted as particularly integral: (1) developing and using conditional genetic knockout models to alter specific genes in specific cell lineages to demonstrate causal niche roles, and (2) using imaging technologies to observe or track stem cell engraftment and behavior within the niche in vivo.
What is the funding mechanism for this opportunity?
The mechanism of support was the NIH Research Project Grant (R01), typically used for mature, hypothesis-driven biomedical research programs.
How much funding did NHLBI plan to commit, and in what fiscal year?
NHLBI indicated it planned to commit up to $3.0 million in fiscal year 2009, contingent on appropriations and the availability of high-quality, responsive applications.
How many awards were anticipated?
The FOA anticipated making approximately 5 to 8 awards.
Was funding guaranteed?
No. As with typical NIH language, funding was contingent on the availability of appropriations and on receiving a sufficient number of meritorious applications that were responsive to the FOA.
What is the Funding Opportunity Number?
The Funding Opportunity Number was RFA-HL-09-010.
What type of opportunity category was this?
The opportunity was categorized as discretionary, used the grant funding instrument type, and fell under the health funding activity category.
What is the associated CFDA number and program name?
The associated CFDA number listed was 93.839, Blood Diseases and Resources Research.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (501(c)(3) and non-501(c)(3)), small businesses, and for-profit organizations other than small businesses.
Were government entities eligible applicants?
Yes. Eligible governmental entities included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Did the FOA explicitly include specific institution types such as HBCUs and tribal organizations?
Yes. The announcement explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments, and tribal organizations (both federally recognized and other than federally recognized).
Were U.S. territories and regional organizations included in eligibility?
Yes. U.S. territories or possessions and regional organizations were noted as eligible. The announcement also noted eligible federal agencies as potential applicants.
Were faith-based or community-based organizations eligible?
Yes. The FOA included faith-based and community-based organizations among eligible applicants.
When was the opportunity posted and created?
The opportunity was posted and created on October 17, 2008.
What were the application due date and closing date?
The original and current closing date listed was January 6, 2009.
When was the opportunity archived?
The archive date was February 6, 2009.
Is this an active funding opportunity?
No. The administrative details place it as a time-limited solicitation from the 2008-2009 cycle, and it has an archive date of February 6, 2009.
What total funding estimate was shown in the source data?
The estimate of total funding shown in the source data was $12,000,000, described as reflecting a broader estimate across the life of awards rather than only the FY2009 commitment amount.
Where were applicants directed for full details about the announcement?
The announcement referenced the NIH Grants Guide page for the RFA for full details.
Who was listed as a contact for access or linking issues?
Contact information was provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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