Opportunity Information: Apply for CDC RFA DD14 1406
Apply for CDC RFA DD14 1406
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.184 Disabilities Prevention.
- This funding opportunity was created on Apr 4, 2014 and posted on Apr 4, 2014.
- Applicants must submit their applications by May 12, 2014 Dates 1. Letter of Intent (LOI) Deadline April 25, 2014, 1159 p.m. U.S. Eastern Standard Time 2. Application Deadline May 12, 2014, 1159 p.m. U.S. Eastern Standard Time, on www.grants.gov 3. Informational conference call for potential applicants April 17, 2014, 100 p.m. U.S. Eastern Standard Time. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,750,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $550,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- A. Eligibility Information 1. Eligible Applicants Government Organizations State or their bona fide agents (includes the District of Columbia) Local governments or their bona fide agents Territorial governments or their bona fide agents in the Commonwealth of Puerto Rico, the Virgin Islands, the Commonwealth of the Northern Marianna Islands, American Samoa, Guam, the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau State controlled institutions of higher education American Indian or Alaska Native tribal governments (federally recognized or state recognized) Public Housing Authorities/Indian Housing Authorities Non government Organizations American Indian or Alaska native tribally designated organizations Nonprofit with 501C3 IRS status (other than institution of higher education) Nonprofit without 501C3 IRS status (other than institution of higher education) Private colleges and universities Community based organizations Faith based organizations For profit organizations (other than small business) Small businesses
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Opportunity Summary:
The grant opportunity titled "Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies" is a CDC discretionary funding announcement (Funding Opportunity Number: CDC RFA DD14-1406) focused on improving public health knowledge about harms and risks linked to therapeutic blood transfusions in people with hemoglobinopathies. Hemoglobinopathies are inherited blood disorders such as sickle cell disease and thalassemia, and many patients require repeated transfusions over long periods of time. Because transfusions can be lifesaving but also carry cumulative risks, the CDC is using this award to strengthen the evidence base on major transfusion-related complications and to build a structure that can support broader, scalable monitoring in the future.
The central purpose of the announcement is to fund a single coordinating center that will develop and manage projects aimed at better characterizing transfusion-related complications. Rather than simply supporting one narrowly defined study, the award is designed to organize and coordinate work that improves understanding of three key complication areas associated with transfusions: alloimmunization (the development of antibodies against transfused blood), iron overload (excess iron accumulation from repeated transfusions that can damage organs), and transfusion-associated infections (infectious risks tied to blood products). A major emphasis is not only on measuring or describing these complications, but also on improving how they are monitored and analyzed across patient populations over time.
A distinct feature of this funding opportunity is its focus on comparing information sources. The coordinating center is expected to help determine how useful pre-existing datasets are for studying alloimmunization, iron overload, and transfusion-associated infections, and to compare those findings against information obtained through primary data collection directly from study participants. In practice, that means the work should examine whether existing records and databases (for example, clinical records, surveillance systems, administrative claims data, blood bank data, registries, or other compiled datasets) can reliably answer key questions, or whether collecting new data from patients is necessary for accuracy and completeness. The CDC frames this comparison as important because if existing datasets can be shown to be valid and informative, monitoring can be expanded more efficiently to larger and more diverse populations in later efforts.
The mechanism for funding is a cooperative agreement, which typically indicates substantial involvement by the CDC in the project beyond standard grant oversight. In cooperative agreements, the awardee usually works closely with the federal agency on planning, methods, and deliverables, making the project more collaborative and aligned with CDC public health priorities. The activity category is listed as Health, and it falls under CFDA number 93.184 (Disabilities Prevention), reflecting the CDC program context in which hemoglobinopathy-related complications are considered.
Funding for the opportunity was structured around one expected award, with an estimated total funding amount of $2,750,000. The award ceiling is $550,000, and the award floor is listed as $0, meaning there is no stated minimum award amount. There is no cost sharing or matching requirement, which lowers financial barriers for applicants that may not have access to non-federal funds to meet match expectations.
The eligibility criteria are broad and include both government and non-government organizations. Eligible governmental applicants include states (and their agents), local governments, and U.S. territorial governments and their agents, as well as state-controlled institutions of higher education and federally or state-recognized American Indian or Alaska Native tribal governments. Eligible non-government applicants include tribally designated organizations, nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those categories), private colleges and universities, community-based organizations, faith-based organizations, for-profit organizations (other than small business), and small businesses. This wide eligibility range suggests the CDC intended to attract applicants with strong clinical, data, and coordination capacity, whether based in public agencies, academic centers, healthcare networks, or other organizations capable of managing multi-partner work.
Key dates for the opportunity reflect a standard federal grant timeline. The announcement was posted on April 4, 2014, with a letter of intent deadline of April 25, 2014 (11:59 p.m. Eastern), and the application deadline of May 12, 2014 (11:59 p.m. Eastern) submitted through Grants.gov. An informational conference call for potential applicants was scheduled for April 17, 2014 at 1:00 p.m. Eastern. The opportunity closed on May 12, 2014 and was archived on June 11, 2014, indicating it is no longer open for applications, but the record remains available for reference.
Overall, this FOA is best understood as an infrastructure-and-evidence building effort: it funds a coordinating center to organize projects that deepen understanding of major transfusion complications in hemoglobinopathies while also testing whether scalable surveillance can be built from existing datasets. The stated long-term goal is to position the CDC to expand monitoring of these complications to a broader population in future projects, using what is learned about data quality, feasibility, and the strengths and limitations of different information sources. For technical assistance accessing the announcement, the CDC Procurement and Grants Office Technical Information Management Section (TIMS) was listed as the contact point (phone 770-488-2700; email pgotim@cdc.gov).
FAQs: Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies (CDC RFA DD14-1406)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies." The Funding Opportunity Number (FON) is CDC RFA DD14-1406.
Which agency is offering this funding?
This is a CDC discretionary funding announcement offered by the U.S. Centers for Disease Control and Prevention (CDC).
What public health issue is this funding meant to address?
The award is aimed at improving public health knowledge about harms and risks linked to therapeutic blood transfusions in people with hemoglobinopathies (inherited blood disorders such as sickle cell disease and thalassemia), particularly where patients may need repeated transfusions over long periods.
What is the main purpose of the funding announcement?
The central purpose is to fund a single coordinating center that will develop and manage projects to better characterize transfusion-related complications in people with hemoglobinopathies and to strengthen the evidence base needed for future, broader monitoring efforts.
Is this grant funding a single research study or something broader?
It is designed to be broader than one narrowly defined study. The award supports organizing and coordinating work across key complication areas and building a structure that can support scalable monitoring in the future.
How many awards were expected under this opportunity?
The funding was structured around one expected award.
What is the funding mechanism?
The mechanism is a cooperative agreement. This typically indicates substantial CDC involvement beyond standard grant oversight, with the awardee working closely with CDC on planning, methods, and deliverables.
What complication areas are specifically highlighted in the announcement?
The announcement highlights three key transfusion-related complication areas: alloimmunization (development of antibodies against transfused blood), iron overload (excess iron accumulation from repeated transfusions that can damage organs), and transfusion-associated infections (infectious risks tied to blood products).
What does alloimmunization mean in the context of this grant?
Alloimmunization is described as the development of antibodies against transfused blood, which can complicate future transfusions for patients who require repeated blood products.
What does iron overload mean in the context of this grant?
Iron overload is described as excess iron accumulation from repeated transfusions, which can damage organs over time.
What does the grant mean by transfusion-associated infections?
Transfusion-associated infections refer to infectious risks tied to blood products. The announcement includes this as one of the three major complication areas to be characterized and monitored.
What is a distinctive feature of this funding opportunity?
A distinctive feature is the focus on comparing information sources. The coordinating center is expected to assess how useful pre-existing datasets are for studying the three complication areas and to compare those findings against information obtained through primary data collection directly from study participants.
What kinds of pre-existing datasets are mentioned as potential information sources?
The announcement gives examples such as clinical records, surveillance systems, administrative claims data, blood bank data, registries, and other compiled datasets.
Why does the CDC emphasize comparing existing datasets with primary data collection?
The CDC frames this comparison as important for determining whether existing records and databases can reliably answer key questions. If existing datasets can be shown to be valid and informative, monitoring can be expanded more efficiently to larger and more diverse populations in later efforts.
What is the long-term goal described for this work?
The long-term goal is to position the CDC to expand monitoring of transfusion-related complications to a broader population in future projects, using what is learned about data quality, feasibility, and the strengths and limitations of different information sources.
What is the activity category for this opportunity?
The activity category is listed as Health.
What CFDA number is associated with this announcement?
The opportunity is associated with CFDA number 93.184 (Disabilities Prevention).
What was the estimated total funding amount?
The estimated total funding amount was $2,750,000.
What was the award ceiling?
The award ceiling was $550,000.
What was the award floor?
The award floor was listed as $0, meaning there was no stated minimum award amount.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement for this opportunity.
Who was eligible to apply as a government applicant?
Eligible governmental applicants included states (and their agents), local governments, U.S. territorial governments and their agents, state-controlled institutions of higher education, and federally or state-recognized American Indian or Alaska Native tribal governments.
Who was eligible to apply as a non-government applicant?
Eligible non-government applicants included tribally designated organizations; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); private colleges and universities; community-based organizations; faith-based organizations; for-profit organizations (other than small business); and small businesses.
What does the broad eligibility suggest about the types of organizations the CDC wanted to attract?
The wide eligibility range suggests the CDC intended to attract applicants with strong clinical, data, and coordination capacity, including organizations based in public agencies, academic centers, healthcare networks, or other entities capable of managing multi-partner work.
When was the announcement posted?
The announcement was posted on April 4, 2014.
Was a letter of intent required, and when was it due?
A letter of intent deadline was listed for April 25, 2014 (11:59 p.m. Eastern).
When was the application due?
The application deadline was May 12, 2014 (11:59 p.m. Eastern), with submission through Grants.gov.
Was there an informational conference call for potential applicants?
Yes. An informational conference call was scheduled for April 17, 2014 at 1:00 p.m. Eastern.
Is this funding opportunity still open?
No. The opportunity closed on May 12, 2014 and was archived on June 11, 2014, meaning it is no longer open for applications (though the record remains available for reference).
Where were applications submitted?
Applications were submitted through Grants.gov.
Who was the listed technical assistance contact for accessing the announcement?
Technical assistance was listed through the CDC Procurement and Grants Office Technical Information Management Section (TIMS), phone 770-488-2700, email pgotim@cdc.gov.
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