Chemical and Biological Defense Innovations and Technologies | Apply Online

Opportunity Summary:

This grant opportunity, titled Chemical and Biological Defense Innovations and Technologies (Funding Opportunity No. N66001 12 X 2002), was issued by the Space and Naval Warfare Systems Center, Pacific (SSC Pacific), on behalf of the Defense Threat Reduction Agency (DTRA). It is structured as a Broad Agency Announcement (BAA) with a specific call under it, Call Opportunity No. R001 (XCEL Program). The overall aim is to fund science and technology research that strengthens Department of Defense capabilities for chemical, biological, and pandemic disease defense, spanning basic research, applied research, and advanced research.

A central focus of Call No. R001 is proof-of-concept work to build an in vitro testing platform made of human organ constructs (often thought of as organ-like tissue models). The intent is for these constructs to mimic real human responses to threat agents closely enough to help predict how people would respond, without relying solely on traditional animal models or late-stage human testing. In practical terms, the government is looking for systems that can recapitulate human response to chemical and biological threats and that can be used to evaluate candidate medical countermeasures (MCMs), including therapeutics and pharmaceuticals. The platform is expected to support more accurate prediction of human safety, efficacy, and pharmacokinetics (how a drug is absorbed, distributed, metabolized, and cleared).

Beyond the organ-construct platform emphasis in the R001 call, the broader BAA scope covers innovative approaches for rapid detection and diagnosis of chemical and biological threats. This includes threats from chemical agents as well as viral, bacterial, and protozoan organisms. The opportunity also highlights the importance of timely dissemination of information to local, state, and federal authorities so they can act quickly, which suggests interest not only in sensors and assays but also in concepts that improve reporting, decision support, and operational coordination during an incident. Overall, the government is seeking next-generation capabilities that move the needle on speed, accuracy, and usefulness of threat detection, characterization, and response.

The solicitation allows multiple funding instruments, including cooperative agreements, grants, contracts, and other procurement mechanisms, depending on the nature of the proposed work and the government role anticipated. There is no stated cost sharing or matching requirement in the provided listing. Eligibility is described as unrestricted, meaning it is broadly open to a wide range of applicant types, subject to any additional eligibility clarifications that may appear in the full announcement.

For submissions, SSC Pacific indicates it is soliciting both White Papers and Full Proposals, with specific requirements and deadlines located in the downloadable Call No. R001 XCEL Program document available through the SSC Pacific e-commerce announcement portal (https://e-commerce.sscno.nmci.navy.mil/). The posting date in the record is December 12, 2011, with an original and current closing date of December 11, 2012, and an archive date of January 10, 2013, which signals this particular posting is historical, even though it remains useful as a reference for the type of work DTRA and SSC Pacific have sought under this BAA framework.

Administrative and regulatory context is tied to DoD assistance and acquisition rules, specifically DoDGARS 22.315(a) and FAR 35.016, which are commonly cited for BAAs supporting research and development. The CFDA listing referenced is 12.335 (Navy Command, Control, Communications, Computers, Intelligence, Surveillance, and Reconnaissance), reflecting the defense-oriented R&D environment supporting the program. For access issues with the announcement materials, the listed point of contact is David Hill, Contract Specialist, at 619-553-4349.

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