Opportunity Information: Apply for RFA OD 15 005
Apply for RFA OD 15 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Chemistry, Toxicology, and Addiction Research on Waterpipe Tobacco (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.077 Family Smoking Prevention and Tobacco Control Act Regulatory Research.
- This funding opportunity was created on Aug 21, 2015 and posted on Aug 21, 2015.
- Applicants must submit their applications by Nov 20, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: For profit organizations other than small businesses City or township governments State governments Independent school districts County governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Chemistry, Toxicology, and Addiction Research on Waterpipe Tobacco (R01) funding opportunity (RFA-OD-15-005) was a discretionary NIH grant program supported with dedicated funds from the FDA Center for Tobacco Products (CTP) to build a stronger evidence base for regulating waterpipe (hookah) tobacco products. The central goal was to stimulate biomedical, behavioral, and social science research that produces data the FDA can actually use when considering or evaluating regulatory actions affecting the manufacture, distribution, and marketing of waterpipe tobacco in order to protect public health. In other words, this FOA was not just about generating general knowledge; it was designed to yield findings directly relevant to FDA tobacco regulatory decisions under the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31.
The opportunity focused on research themes implied by its title: chemistry, toxicology, and addiction. Projects were expected to help clarify what people are exposed to when they use waterpipe products, how harmful or addictive those exposures may be, and what product characteristics or use behaviors drive risk. This can include studying the constituents and emissions generated during waterpipe use, identifying toxicants or harmful and potentially harmful constituents, and examining factors that influence nicotine delivery and dependence. Because waterpipe use involves a device, charcoal heating, flavored tobacco, and distinctive puffing patterns, the FOA aimed to support work that disentangles how these features change chemical output and user exposure compared to other tobacco products, and how that information could support product standards, labeling, marketing restrictions, or other regulatory approaches.
Administratively, awards were made by NIH but funded through FDA CTP tobacco regulatory science resources, reflecting a partnership where NIH manages the grant process and scientific oversight while FDA’s regulatory mission shapes the priority questions. The Funding Instrument Type was a Grant using the R01 mechanism, and the activity category was Health. The FOA anticipated up to 10 awards, with an estimated total funding amount of about $3,000,000 and an award ceiling of $300,000. There was no cost-sharing or matching requirement, which lowered barriers for applicants who might otherwise struggle to meet matching commitments.
Eligibility was broad and included many organization types across the public, private, and nonprofit sectors. Eligible applicants included for-profit organizations (including small businesses and other than small businesses), nonprofits (both 501(c)(3) and certain non-501(c)(3) organizations), public and state-controlled institutions of higher education, private institutions of higher education, and a wide range of governmental entities (state, county, city/township, special district governments). The FOA also allowed applications from Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized tribal governments), public housing authorities/Indian housing authorities, and additional categories such as faith-based or community-based organizations and eligible federal agencies. It explicitly encompassed a variety of minority-serving and specialized institutions, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities (TCCUs). It also permitted non-domestic (non-U.S.) entities and foreign organizations, regional organizations, and U.S. territories or possessions, which signaled an interest in expanding the evidence base beyond a single domestic context when that work could inform U.S. regulatory priorities.
Key administrative dates indicate this was a time-limited opportunity. It was posted and created on August 21, 2015, with an original and current closing date of November 20, 2015, and an archive date of December 21, 2015. The listing referenced CFDA number 93.077 under the Family Smoking Prevention and Tobacco Control Act Regulatory Research category. For applicants or readers needing more details at the time, the FOA directed them to the full announcement on the NIH grants website and provided NIH Office of Extramural Research (OER) webmaster contacts for technical access issues.
Taken together, this FOA was built to fund targeted, regulatory-relevant research on hookah products, prioritizing studies that could translate into practical evidence for FDA decision-making. The emphasis on chemistry, toxicology, and addiction reflects the kinds of core questions regulators need answered: what the product delivers, what harms it can cause, how dependence develops or is maintained, and which product features or use patterns could be addressed through regulation to reduce population-level harm.
FAQs: Chemistry, Toxicology, and Addiction Research on Waterpipe Tobacco (R01) - RFA-OD-15-005
What is this funding opportunity?
This opportunity, titled Chemistry, Toxicology, and Addiction Research on Waterpipe Tobacco (R01) (FOA RFA-OD-15-005), was a discretionary NIH grant program supported with dedicated funds from the FDA Center for Tobacco Products (CTP). It was designed to strengthen the scientific evidence base used to regulate waterpipe (hookah) tobacco products.
What was the main goal of the program?
The central goal was to stimulate biomedical, behavioral, and social science research that produces data the FDA can use when considering or evaluating regulatory actions affecting the manufacture, distribution, and marketing of waterpipe tobacco to protect public health.
How is this different from a general tobacco research grant?
This FOA was specifically aimed at generating findings that are directly relevant to FDA tobacco regulatory decision-making under the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. It was not intended solely to produce general knowledge; the emphasis was on evidence that could inform potential regulatory approaches.
Which research areas did the FOA emphasize?
The opportunity focused on three themes reflected in the title: chemistry, toxicology, and addiction. Projects were expected to clarify exposures from waterpipe use, assess potential harm and addictive potential, and identify which product characteristics or use behaviors drive risk.
What types of questions were projects expected to answer?
Projects were expected to help answer core regulatory science questions, such as:
- What constituents and emissions are generated during waterpipe use?
- What toxicants or harmful and potentially harmful constituents may be present?
- What are users exposed to, and how harmful or addictive might those exposures be?
- What factors influence nicotine delivery and dependence in waterpipe use?
- How do device design, charcoal heating, flavors, and puffing patterns affect chemical output and exposure?
Why did the FOA highlight device features, charcoal heating, flavors, and puffing patterns?
Waterpipe use is distinct because it involves a device, often uses charcoal heating, commonly includes flavored tobacco, and has distinctive puffing patterns. The FOA sought research that disentangles how these features change chemical emissions and user exposure, compared to other tobacco products, in ways that could inform regulation.
What kinds of regulatory actions could this research support?
The FOA described research intended to support evidence for FDA decision-making, potentially relevant to approaches such as product standards, labeling, marketing restrictions, or other regulatory options that could reduce harms or exposures at a population level.
Who administered the awards and who provided the funds?
Awards were made by NIH but were funded through FDA CTP tobacco regulatory science resources. This reflects a partnership where NIH manages the grant process and scientific oversight while FDA CTP’s regulatory mission helps shape the priority questions.
What funding mechanism was used?
The funding instrument was a Grant using the R01 mechanism. The activity category listed was Health.
How many awards were anticipated?
The FOA anticipated up to 10 awards.
What was the estimated total funding available?
The estimated total funding amount was about $3,000,000.
Was there an award ceiling?
Yes. The award ceiling was listed as $300,000.
Was cost-sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included many types of organizations across public, private, nonprofit, and government sectors, including:
- For-profit organizations (including small businesses and other than small businesses)
- Nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations)
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- State governments, county governments, city/township governments, and special district governments
- Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized tribal governments)
- Public housing authorities/Indian housing authorities
- Faith-based or community-based organizations
- Eligible federal agencies
Were minority-serving and specialized institutions included?
Yes. The FOA explicitly encompassed a variety of minority-serving and specialized institutions, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Asian American and Native American Pacific Islander-Serving Institutions (AANAPISIs)
- Alaska Native and Native Hawaiian-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
Could non-U.S. organizations apply?
Yes. The FOA permitted non-domestic (non-U.S.) entities and foreign organizations, as well as regional organizations and applicants from U.S. territories or possessions, when the work could inform U.S. regulatory priorities.
What was the CFDA number associated with this opportunity?
The listing referenced CFDA 93.077 under the Family Smoking Prevention and Tobacco Control Act Regulatory Research category.
When was the opportunity posted and when did it close?
The opportunity was posted/created on August 21, 2015. The original and current closing date was November 20, 2015.
Is the opportunity still open?
No. The FOA was time-limited and is no longer active. It had an archive date of December 21, 2015.
Where were applicants directed for the full announcement?
The FOA directed applicants to the full announcement on the NIH grants website for complete details.
Who could be contacted for technical access issues?
For technical access issues, the listing referenced contacts through the NIH Office of Extramural Research (OER) webmaster.
What overall impact was this FOA intended to have?
Taken together, the FOA was intended to fund targeted, regulatory-relevant research on hookah products to help answer practical questions regulators face: what the product delivers, what harms it can cause, how dependence develops or is maintained, and which product features or use patterns could be addressed through regulation to reduce public health harm.
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