Childhood Obesity Prevention and Treatment Research Coordinating Unit (U01) | Apply Online

Opportunity Summary:

The Childhood Obesity Prevention and Treatment Research Coordinating Unit (U01) opportunity (RFA HL 10 005) is a National Institutes of Health cooperative agreement led by the National Heart, Lung, and Blood Institute (NHLBI) in partnership with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its core purpose is to fund a single coordinating unit that provides the organizing and operational backbone for a broader Childhood Obesity Prevention and Treatment Research Consortium. This coordinating unit award is designed to run in parallel with a separate companion announcement (RFA HL 10 004) that supports four clinical trial awards. In other words, the trials generate the intervention evidence, while this U01 coordinating unit keeps the consortium aligned, efficient, and collaborative so the overall program functions as an integrated multi-site research effort rather than a set of disconnected studies.

A central feature of the announcement is how it defines the scope of "prevention" and "treatment" in childhood obesity research. Prevention is framed broadly to include both primary prevention (stopping excess weight gain in youth who are not overweight) and secondary prevention (preventing additional weight gain in children and adolescents who are already overweight or obese). Treatment is defined as achieving weight reduction in children who are obese or severely obese, including approaches where success may look like weight loss or weight maintenance while a child grows taller, thereby improving weight status relative to height over time. This framing recognizes that pediatric obesity outcomes are not always measured the same way as adult outcomes and that healthy growth patterns matter when evaluating intervention impact.

The coordinating unit is expected to carry out "coordinating functions" that support collaboration, communication, and shared scientific progress across the consortium. While the brief description does not list every task, the intent is clear: the coordinating unit serves as the hub for coordination and exchange of scientific information among participating institutions, and it helps build partnerships with local, state, and national agencies. The emphasis on partnerships signals that the program is meant to connect research to real-world systems and stakeholders, which is particularly important for childhood obesity interventions that often involve schools, communities, healthcare settings, and public health agencies. The program is explicitly designed to promote collaboration and coordination, which is a hallmark of cooperative agreements where NIH has substantial involvement and expectations for ongoing program stewardship.

The overarching goal of the entire program is improved childrens health through preventing obesity-related morbidity and mortality, especially impacts tied to cardiovascular disease and other chronic conditions. By positioning NHLBI as a lead institute, the opportunity highlights the long-term cardiometabolic consequences of childhood obesity and aims to support research infrastructure that can generate strong, comparable evidence across multiple trials. The consortium model also suggests a desire for harmonized methods, shared learning, and more rapid translation of findings, since coordinated multi-site programs can standardize measures and accelerate dissemination compared to stand-alone projects.

Administratively, this is a discretionary grant using the Cooperative Agreement funding instrument (U01). No cost sharing or matching is required. The opportunity was posted February 2, 2009, with an application closing date of October 6, 2009, and it was archived November 6, 2009. The CFDA numbers associated with the program reflect its dual-institute nature: 93.837 (Cardiovascular Diseases Research) and 93.865 (Child Health and Human Development Extramural Research). Although the archived status means it is no longer open for applications, the description captures a common NIH approach to complex public health problems: fund multiple trials plus a central coordinating unit to ensure consistency, high-quality operations, and meaningful cross-site collaboration.

Eligibility is broad and spans many organization types, reflecting the community and cross-sector relevance of pediatric obesity work. Eligible applicants include public and state-controlled and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations other than small businesses, state governments, and federally recognized tribal governments, as well as tribal organizations that are not federally recognized. Additional eligible groups explicitly include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, U.S. territories or possessions, and faith-based or community-based organizations, along with eligible federal agencies. This wide eligibility range aligns with the FOA emphasis on partnerships and the need to conduct or support work that spans research institutions and the community contexts where prevention and treatment interventions take place.

For further details, the full announcement was hosted through the NIH grants guide under RFA HL 10 005, with technical assistance available through the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.

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