Opportunity Information: Apply for RFA ES 15 010
Apply for RFA ES 15 010
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Childrens Health Exposure Analysis Resource (CHEAR) Data Repository, Analysis and Science Center (U2C)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
- This funding opportunity was created on Feb 26, 2015 and posted on Feb 26, 2015.
- Applicants must submit their applications by Apr 30, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $9,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $6,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Small businesses State governments County governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Childrens Health Exposure Analysis Resource (CHEAR) Data Repository, Analysis and Science Center (U2C) funding opportunity (RFA ES 15 010) is a National Institutes of Health initiative led by the National Institute of Environmental Health Sciences (NIEHS) to build national infrastructure that helps researchers incorporate environmental exposure data into studies of childrens health. The core idea behind CHEAR is to lower the practical barriers that many NIH funded investigators face when they want to measure environmental exposures (such as chemicals, pollutants, or other biomarkers of exposure) and then analyze those exposure data in a statistically sound and reusable way. Rather than each study having to create its own lab and data analysis pipeline from scratch, CHEAR is designed as a shared resource that provides standardized, high quality exposure assessment capabilities to the broader extramural research community.
This specific FOA solicits applications for one major component of the CHEAR network: the Data Repository, Analysis, and Science Center, referred to as the Data Center. CHEAR is described as a multi unit network, and alongside the Data Center it includes (1) a National Exposure Assessment Laboratory Network that focuses on generating exposure measurements and (2) an overall CHEAR Coordinating Center that helps organize and coordinate the program. The Data Center sits at the intersection of those efforts by taking the exposure data generated through CHEAR supported projects and ensuring it can be maintained, curated, analyzed, interpreted, and ultimately reused in ways that maximize scientific value.
The Data Center is expected to provide two distinct, outward facing services to the extramural community. First, it serves as a statistical and methods resource. That includes offering statistical consultation to investigators using CHEAR, conducting statistical analyses for studies that leverage the CHEAR infrastructure, and developing and sharing improved statistical methods and informatics tools tailored to exposure data and childrens health research. This emphasis reflects how complex exposure data can be, especially when studies involve mixtures of chemicals, time varying exposures, multiple biospecimen types, detection limits, batch effects, and the need to connect exposure measures to health outcomes while accounting for confounders and study design constraints. The intent is not only to run analyses for individual projects, but also to strengthen the field by creating methods and tools that can be disseminated and used more broadly.
Second, the Data Center is responsible for building and operating an exposure data repository and related data science resources. In practice, that means putting in place systems and workflows to store exposure datasets, document them thoroughly, manage metadata and data dictionaries, support data quality control and harmonization where appropriate, and enable responsible sharing and reuse. The FOA frames the end goal as maximizing the potential use and impact of exposure data both within CHEAR and outside of it, which implies an emphasis on curation, standardization, discoverability, and long term utility rather than one off data handling. The repository function is meant to help ensure that exposure data produced with CHEAR support do not remain siloed within a single project, but can contribute to future secondary analyses, cross study comparisons, and method development, consistent with applicable privacy, consent, and governance requirements.
From a funding and administrative standpoint, this opportunity is a discretionary NIH cooperative agreement (U2C). A cooperative agreement mechanism typically signals substantial NIH programmatic involvement compared with a standard research grant, meaning the awardee should expect active coordination with NIEHS and the broader CHEAR network to meet shared program goals, align operations across centers, and deliver services to outside investigators. The opportunity anticipated a single award (ExpectedAwards: 1), with an estimated total funding level of about $9,000,000 and an award ceiling listed as $6,000,000. No cost sharing or matching was required. The posting date was February 26, 2015, with an application closing date of April 30, 2015, and an archive date of May 31, 2015.
Eligibility was broad and included many types of domestic organizations such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for profit organizations other than small businesses, and a wide range of governmental entities (state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities). The FOA also explicitly included a range of institution types and community based entities such as HBCUs, Hispanic serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith based or community based organizations, among others. Foreign entities were not eligible to apply, and foreign components of U.S. organizations were not allowed, consistent with NIH policy language in the announcement.
Overall, this FOA is centered on building a national level data and analytics backbone for CHEAR so that childrens health researchers can more readily add robust environmental exposure assessment to their NIH funded studies. By combining advanced statistical support with a carefully managed exposure data repository, the Data Center is meant to increase the quality, comparability, and scientific reach of exposure data, making those data easier to analyze correctly in the short term and more valuable for future discovery over the long term.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is the Childrens Health Exposure Analysis Resource (CHEAR) Data Repository, Analysis and Science Center (U2C) funding opportunity (RFA ES 15 010). It is a National Institutes of Health (NIH) initiative led by the National Institute of Environmental Health Sciences (NIEHS) to build national infrastructure that helps researchers incorporate environmental exposure data into studies of childrens health.
What is CHEAR and what problem is it trying to solve?
CHEAR is designed to lower practical barriers for NIH-funded investigators who want to measure environmental exposures (for example, chemicals, pollutants, or other biomarkers of exposure) and analyze those exposure data in a statistically sound and reusable way. Instead of each study building its own laboratory and data analysis pipeline, CHEAR provides shared, standardized exposure assessment capabilities to the extramural research community.
What component of CHEAR is being funded under this FOA?
This FOA solicits applications for the CHEAR Data Repository, Analysis, and Science Center, referred to as the Data Center. It is one major component of the overall CHEAR network.
How does the Data Center fit into the broader CHEAR network?
CHEAR is described as a multi-unit network that includes: (1) a National Exposure Assessment Laboratory Network focused on generating exposure measurements, (2) a CHEAR Coordinating Center that helps organize and coordinate the program, and (3) the Data Center. The Data Center sits at the intersection by taking exposure data generated through CHEAR-supported projects and ensuring it can be maintained, curated, analyzed, interpreted, and reused to maximize scientific value.
What are the two main outward-facing services the Data Center must provide?
The Data Center is expected to provide two distinct services to the extramural community: (1) statistical and methods support, and (2) an exposure data repository with related data science resources.
What does the statistical and methods resource service include?
It includes providing statistical consultation to investigators using CHEAR, conducting statistical analyses for studies leveraging CHEAR infrastructure, and developing and sharing improved statistical methods and informatics tools tailored to exposure data and childrens health research.
Why does the FOA emphasize statistical methods for exposure data?
The FOA highlights that exposure data can be complex, including issues like mixtures of chemicals, time-varying exposures, multiple biospecimen types, detection limits, batch effects, and the challenge of connecting exposure measures to health outcomes while accounting for confounders and study design constraints.
Is the Data Center only expected to analyze data for individual projects?
No. The intent includes running analyses for individual projects and also strengthening the field by creating methods and tools that can be disseminated and used more broadly.
What does the exposure data repository function involve?
The Data Center is responsible for building and operating an exposure data repository and related data science resources. This includes establishing systems and workflows to store exposure datasets, document them thoroughly, manage metadata and data dictionaries, support data quality control and harmonization where appropriate, and enable responsible sharing and reuse.
What is the end goal of the data repository, as described in the FOA?
The stated end goal is to maximize the potential use and impact of exposure data both within CHEAR and outside of it. That implies a focus on curation, standardization, discoverability, and long-term utility rather than one-off data handling.
Does the FOA expect the repository to support data reuse beyond the original study?
Yes. The repository is meant to help ensure that exposure data produced with CHEAR support do not remain siloed within a single project, but can contribute to future secondary analyses, cross-study comparisons, and method development, consistent with applicable privacy, consent, and governance requirements.
What funding mechanism is used for this award?
This opportunity uses a discretionary NIH cooperative agreement mechanism (U2C).
What does it mean that this is a cooperative agreement (U2C)?
A cooperative agreement typically signals substantial NIH programmatic involvement compared with a standard research grant. The awardee should expect active coordination with NIEHS and the broader CHEAR network to meet shared program goals, align operations across centers, and deliver services to outside investigators.
How many awards were anticipated?
The FOA anticipated a single award (ExpectedAwards: 1).
What was the estimated total funding level and the award ceiling?
The estimated total funding level was about $9,000,000, and the award ceiling was listed as $6,000,000.
Was cost sharing or matching required?
No cost sharing or matching was required.
When was the FOA posted and what were the key dates?
The posting date was February 26, 2015. The application closing date was April 30, 2015. The archive date was May 31, 2015.
Who was eligible to apply?
Eligibility was broad and included many types of domestic organizations, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, and a wide range of governmental entities (including state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities).
Does the FOA mention specific institution types or community-based entities as eligible?
Yes. The FOA explicitly included a range of institution types and community-based entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, among others.
Are foreign entities eligible to apply?
No. Foreign entities were not eligible to apply.
Are foreign components of U.S. organizations allowed?
No. Foreign components of U.S. organizations were not allowed, consistent with NIH policy language in the announcement.
What kinds of data is CHEAR focused on supporting?
CHEAR focuses on environmental exposure data relevant to childrens health, including measurements related to chemicals, pollutants, and other biomarkers of exposure, along with the associated information needed to analyze and interpret those exposure data.
What is the overall purpose of funding the Data Center?
The FOA is centered on building a national-level data and analytics backbone for CHEAR so that childrens health researchers can more readily add robust environmental exposure assessment to their NIH-funded studies.
How is the Data Center expected to increase the scientific value of exposure data?
By combining advanced statistical support with a carefully managed exposure data repository, the Data Center is meant to increase the quality, comparability, and scientific reach of exposure data, making those data easier to analyze correctly in the short term and more valuable for future discovery over the long term.
Who leads this NIH initiative?
The CHEAR initiative is led by the National Institute of Environmental Health Sciences (NIEHS) within NIH.
Who are the primary users of the Data Centers services?
The Data Centers outward-facing services are intended for the extramural research community, particularly investigators using or leveraging CHEAR-supported infrastructure.
Browse more opportunities from the same category: Environment Health
Next opportunity: Childrens Health Exposure Analysis Resource (CHEAR) Coordinating Center (U24)
Previous opportunity: Childrens Health Exposure Analysis Resource (CHEAR) National Exposure Assessment Laboratory Network (U2C)
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