Chronic Illness Self Management in Children and Adolescents (R01) | Apply Online

Opportunity Summary:

This government grant opportunity, titled Chronic Illness Self Management in Children and Adolescents (R01) (Funding Opportunity Number PA 11-070), is a National Institutes of Health (NIH) research funding announcement designed to expand and strengthen the evidence base on how to help young people with chronic physical illnesses manage their conditions more effectively and maintain a better quality of life over time. Multiple NIH Institutes and Centers jointly issued the announcement, including the National Institute of Nursing Research (NINR), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Heart, Lung, and Blood Institute (NHLBI). The overall focus is on supporting rigorous research projects under the NIH R01 mechanism, meaning investigator-initiated, hypothesis-driven studies that can meaningfully advance knowledge and inform real-world self-management strategies for pediatric and adolescent populations living with chronic illness.

The central purpose of the opportunity is to encourage research that improves self-management and quality of life for children and adolescents who must live day-to-day with chronic disease. The announcement emphasizes that once a child is diagnosed with a chronic illness, both the child and their family typically take on a lifelong responsibility for ongoing self-management. That includes the daily behaviors, decisions, and routines needed to maintain health, reduce symptoms, and prevent complications, as well as the longer-term work of adapting to changing needs as the child grows into adolescence and early adulthood. The FOA is aimed at generating practical, science-based approaches that make self-management more successful, sustainable, and developmentally appropriate across this age span.

A major theme of the announcement is that self-management in youth does not happen in isolation, so studies are encouraged to examine biobehavioral processes in the context of family dynamics and the broader family-community environment. In practice, this means NIH is looking for research that considers how physiological factors and health outcomes intersect with behavior, learning, motivation, stress, coping, social support, communication patterns, and the shared responsibilities between children, caregivers, and sometimes schools or community organizations. Projects can focus on how children and families develop skills for medication adherence, symptom monitoring, diet and activity management, use of medical devices, recognition of warning signs, and appropriate use of healthcare services, while also addressing barriers that commonly undermine consistency over time.

The scope is intentionally broad with respect to the kinds of mechanisms and influences investigators can study. The FOA explicitly welcomes research tied to biological and technological factors, along with sociocultural, environmental, and behavioral mechanisms that contribute to successful self-management. This leaves room for studies that explore, for example, how stress physiology or sleep influences self-management capacity, how health technologies and devices support tracking or adherence, and how factors such as culture, language, family resources, neighborhood conditions, or access to care shape a young person’s ability to manage a chronic condition. The emphasis is on understanding what drives sustained self-management and translating that understanding into interventions or strategies that measurably improve health and quality of life.

The eligible participant population is clearly defined. Proposed studies must focus on chronic illnesses in children and adolescents ages 8 through 21. The FOA allows investigators to group participants by developmental stages at their discretion, which acknowledges that self-management expectations and capabilities change substantially across late childhood, adolescence, and the transition into young adulthood. At the same time, the announcement draws boundaries around what is not included. Studies focused on chronic mental illness or serious cognitive disability are outside the scope of this FOA, so applications centered primarily on those conditions or populations would not be responsive.

From an administrative standpoint, this is a discretionary grant opportunity using the NIH grant funding instrument, with activity areas spanning health-related research domains reflected in the CFDA listings, including nursing research (93.361), cardiovascular diseases research (93.837), arthritis and musculoskeletal and skin diseases research (93.846), diabetes/digestive/kidney diseases extramural research (93.847), and child health and human development extramural research (93.865). The announcement states there is no cost sharing or matching requirement, which is typical for NIH research grants and means applicants are not required to contribute non-federal funds as a condition of the award.

Eligibility is broad and includes many types of applicant organizations, reflecting NIH’s intent to encourage strong proposals from academic, clinical, community, governmental, and private-sector settings. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses), state, county, city/township, and special district governments, independent school districts, public housing authorities/Indian housing authorities, and federally recognized tribal governments and other tribal organizations. The eligibility language also explicitly includes a range of mission-focused and underserved-serving institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This breadth supports the idea that impactful self-management research may be led not only by traditional research universities, but also by community and service organizations embedded in the settings where children and families actually live and manage chronic disease.

Key dates provided in the source reflect the lifecycle of the announcement rather than a currently open competition. The FOA was posted on December 9, 2010, with an archive date of January 11, 2014. The original closing date was January 7, 2014, and the current closing date is listed as December 11, 2013, indicating the opportunity is historical/archived rather than active. The sponsoring agency is NIH, and the full announcement was hosted on the NIH grants site under the provided link. For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

In plain terms, this FOA was meant to fund robust R01-level research that helps children and adolescents with chronic physical illnesses, along with their families, build and sustain the skills and supports needed for lifelong self-management. It prioritizes work that takes development seriously, accounts for family and community context, and investigates a mix of behavioral, environmental, sociocultural, biological, and technological contributors to better health outcomes and quality of life, while excluding chronic mental illness and serious cognitive disability as primary study targets.

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