Opportunity Information: Apply for PA 11 072

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Chronic Illness Self Management in Children and Adolescents (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.837 Cardiovascular Diseases Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 11, 2013 and posted on Dec 9, 2010.
  • Applicants must submit their applications by Dec 11, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Independent school districts Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Public and State controlled institutions of higher education State governments County governments City or township governments Special district governments Private institutions of higher education For profit organizations other than small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Chronic Illness Self Management in Children and Adolescents (R21) funding opportunity (PA 11-072) is a National Institutes of Health (NIH) research grant designed to spur early-stage, exploratory studies that can strengthen self-management and improve quality of life for young people living with chronic physical health conditions. It is sponsored by multiple NIH institutes, including the National Institute of Nursing Research (NINR), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Heart, Lung, and Blood Institute (NHLBI). The central idea behind the announcement is that children and adolescents with chronic illnesses, along with their families, face a long-term and often lifelong need to manage symptoms, treatments, and daily health behaviors in order to stay well and prevent complications, and that better science is needed to understand what helps self-management succeed over time.

The FOA encourages research that looks beyond medical treatment alone and digs into how self-management actually happens in real life for youth ages 8 through 21. Applicants are expected to focus on chronic illness self-management in this age range and can group participants by developmental stages in ways that make sense for the proposed science (for example, middle childhood, early adolescence, late adolescence, and emerging adulthood). A key emphasis is on biobehavioral research and on studies that consider the child in context, meaning projects that examine interactions among the child or adolescent, their family routines and relationships, and the broader community environments that shape health behaviors. The announcement also highlights interest in mechanisms that drive successful self-management, including behavioral factors (such as adherence, motivation, coping skills, and habit formation), sociocultural influences (such as beliefs about illness, family roles, language, and culturally shaped practices), environmental conditions (such as school policies, neighborhood resources, or access to care), and biological or technological factors (such as biomarkers related to disease control or the role of health technologies that support monitoring and decision-making).

Although the announcement is broad in the chronic illnesses it can cover, it is explicit about what is not included: studies focused on chronic mental illness or serious cognitive disability fall outside the scope of this particular opportunity. The grant mechanism is an R21, which generally signals support for innovative, pilot, or proof-of-concept projects that can open up new directions, generate preliminary data, or test promising approaches that may later be expanded through larger research awards. The listed award ceiling is $200,000, and there is no cost-sharing or matching requirement.

Eligibility is intentionally wide to allow strong ideas to come from many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (including faith-based or community-based organizations), small businesses, for-profit organizations other than small businesses, independent school districts, and a range of government entities such as state, county, city or township, special district governments, and U.S. territories or possessions. The FOA also includes eligibility for tribal governments and tribal organizations (including federally recognized tribes and other tribal entities), tribally controlled colleges and universities, and several institution types that serve specific populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, and Alaska Native and Native Hawaiian-serving institutions. Public housing authorities and Indian housing authorities are also listed as eligible, reflecting the FOA's openness to community-rooted settings where chronic disease self-management challenges and solutions may be especially visible.

From an administrative standpoint, the opportunity is categorized as a discretionary grant within the broad activity areas of education, health, income security, and social services, and it is associated with multiple CFDA numbers reflecting the participating NIH institutes and relevant research domains (nursing research, cardiovascular disease research, arthritis and musculoskeletal/skin diseases research, and child health and human development research). The FOA was originally posted in December 2010 and reflects an archived opportunity with closing and archive dates in 2013-2014, but the core description clarifies the NIH program intent: to build the evidence base for practical, sustainable, developmentally appropriate self-management strategies for children and adolescents living with chronic physical illnesses, while accounting for the family and community systems that shape everyday health behavior. For full details, NIH points applicants to the archived program announcement page at http://grants.nih.gov/grants/guide/pa-files/PA-11-072.html.

Frequently Asked Questions (FAQs)

What is the Chronic Illness Self Management in Children and Adolescents (R21) funding opportunity (PA 11-072)?

This is an NIH research grant opportunity intended to spur early-stage, exploratory studies focused on improving chronic illness self-management and quality of life for children, adolescents, and young adults living with chronic physical health conditions. It uses the NIH R21 mechanism, which is commonly used for innovative, pilot, or proof-of-concept projects.

What is the main purpose of this FOA?

The FOA aims to strengthen the science of how young people (and their families) successfully manage chronic physical illnesses over time in real life, beyond medical treatment alone. The emphasis is on building an evidence base for practical, sustainable, developmentally appropriate self-management strategies that can help prevent complications and support long-term well-being.

Which NIH institutes sponsor or participate in this opportunity?

The opportunity is sponsored by multiple NIH institutes, including the National Institute of Nursing Research (NINR), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Heart, Lung, and Blood Institute (NHLBI).

Who is the target population for the research supported by this FOA?

The FOA targets youth ages 8 through 21 who are living with chronic physical health conditions. The announcement also recognizes the important role of families and encourages research that includes family context and broader community environments.

Can applicants divide participants by age or developmental stage?

Yes. Applicants can group participants by developmental stages in ways that fit the proposed science, such as middle childhood, early adolescence, late adolescence, and emerging adulthood.

What kinds of research approaches does the FOA encourage?

The FOA encourages biobehavioral research and studies that examine self-management as it occurs in everyday settings. It highlights work that considers the child or adolescent in context, including interactions among the youth, family routines and relationships, and community environments that shape health behaviors.

What does "self-management" mean in the context of this FOA?

In this FOA, self-management refers to the ongoing, long-term activities involved in managing symptoms, treatments, and daily health behaviors to stay well and prevent complications. This includes what the child or adolescent does and how families and environments support or hinder those behaviors.

What types of mechanisms or drivers of successful self-management are of interest?

The FOA highlights interest in mechanisms that support successful self-management, including behavioral factors (such as adherence, motivation, coping skills, and habit formation), sociocultural influences (such as beliefs about illness, family roles, language, and culturally shaped practices), environmental conditions (such as school policies, neighborhood resources, or access to care), and biological or technological factors (such as biomarkers related to disease control or health technologies that support monitoring and decision-making).

Is this FOA limited to specific chronic illnesses?

The announcement is broad with respect to which chronic physical illnesses may be studied, as long as the research is focused on chronic illness self-management in youth ages 8 to 21 and aligns with the overall intent of the FOA.

Are studies on chronic mental illness included?

No. Studies focused on chronic mental illness fall outside the scope of this opportunity.

Are studies involving serious cognitive disability included?

No. The FOA explicitly notes that studies focused on serious cognitive disability are outside the scope of this particular opportunity.

What grant mechanism is used, and what does it imply about project scope?

This is an R21 mechanism, which generally supports innovative, early-stage studies such as pilot work or proof-of-concept research. The intent is often to generate preliminary data, test promising approaches, or open new research directions that may later be expanded under larger awards.

What is the award ceiling for this opportunity?

The listed award ceiling is $200,000.

Is cost sharing or matching required?

No. The FOA states there is no cost-sharing or matching requirement.

What types of organizations are eligible to apply?

Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (including faith-based or community-based organizations); small businesses; for-profit organizations other than small businesses; independent school districts; and government entities such as state, county, city or township, special district governments, and U.S. territories or possessions.

Are tribal governments and tribal organizations eligible?

Yes. The FOA includes eligibility for tribal governments and tribal organizations, including federally recognized tribes and other tribal entities, as well as tribally controlled colleges and universities.

Are minority-serving institutions specifically included in eligibility?

Yes. The FOA lists several institution types that serve specific populations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, and Alaska Native and Native Hawaiian-serving institutions.

Are community-rooted or housing-related public entities eligible?

Yes. Public housing authorities and Indian housing authorities are listed among eligible applicants, reflecting openness to community-based settings where chronic disease self-management challenges and solutions may be especially visible.

How is this opportunity categorized from an administrative perspective?

It is categorized as a discretionary grant and is associated with broad activity areas including education, health, income security, and social services. It is also linked to multiple CFDA numbers reflecting participating NIH institutes and relevant research domains (for example, nursing research, cardiovascular disease research, arthritis and musculoskeletal/skin diseases research, and child health and human development research).

Is this FOA current or archived?

The FOA was originally posted in December 2010 and is described as an archived opportunity with closing and archive dates in 2013-2014. The archived listing still describes the NIH program intent and research priorities for this announcement.

Where can the official archived NIH program announcement be found?

The archived program announcement page is available at http://grants.nih.gov/grants/guide/pa-files/PA-11-072.html.

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