Opportunity Information: Apply for RFA NR 15 001
Apply for RFA NR 15 001
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Chronic Wounds Advancing the Science from Prevention to Healing (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on May 6, 2014 and posted on May 6, 2014.
- Applicants must submit their applications by Jul 24, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public and State controlled institutions of higher education Special district governments County governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Chronic Wounds Advancing the Science from Prevention to Healing (R01) is a National Institutes of Health (NIH) funding opportunity designed to push chronic wound research forward, from understanding why wounds become chronic in the first place to testing practical ways to prevent them and help them heal faster. The focus is on common and costly chronic wounds such as diabetic foot ulcers, pressure injuries, and venous or arterial ulcers. The FOA is built around the idea that chronic wounds are not just a local skin problem but a complex condition shaped by biological processes and real-world psychosocial factors that influence risk, progression, symptoms, healing, and long-term outcomes. The overarching goal is to generate findings that help identify who is most at risk and to support the development of more tailored, effective strategies that improve healing, reduce complications, and protect quality of life.
From a scientific standpoint, the announcement invites research that strengthens the evidence base on the mechanisms behind chronic wound development, persistence, and repair. That includes biological contributors such as impaired perfusion, inflammation and immune dysregulation, infection and biofilms, neuropathy, metabolic dysfunction (including diabetes-related effects), tissue oxygenation, cellular senescence, or other physiologic barriers that slow or prevent healing. At the same time, it explicitly recognizes psychosocial and behavioral drivers that can influence outcomes, such as symptom burden (pain, itching, odor, exudate), adherence to offloading or compression, mobility limitations, self-care capacity, stress, depression, social support, and the broader care environment. In practice, projects could range from studies that clarify risk pathways and markers for chronicity to research that explains why some patients do poorly despite receiving standard wound care.
A major emphasis of the FOA is intervention development and testing. The opportunity supports work aimed at preventing chronic wounds before they start (for example, prevention strategies for high-risk patients with diabetes, limited mobility, vascular disease, or sensory loss), accelerating the healing process once a wound exists (such as approaches that address underlying biological barriers, optimize local wound conditions, or improve adherence to evidence-based care), and reducing or managing wound-related symptoms that affect daily functioning and well-being. The announcement frames these intervention goals broadly, allowing for innovations that could be clinical, behavioral, educational, systems-level, or technology-enabled, as long as they are grounded in a strong rationale and are designed to improve patient-centered outcomes.
This FOA uses the NIH R01 grant mechanism, meaning it is intended for substantial, hypothesis-driven research projects that can produce generalizable knowledge. The funding opportunity number is RFA-NR-15-001, and it falls under CFDA 93.361 (Nursing Research), signaling that while applicants may come from many disciplines, the program aligns strongly with nursing science priorities such as symptom science, self-management, care delivery, and quality-of-life outcomes. The total estimated funding for the opportunity is $3,000,000, with an award ceiling of $350,000. There is no cost-sharing or matching requirement, which lowers a common barrier for many institutions and community-based partners.
Eligibility is broad and includes many types of U.S. organizations and governments, such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) entities), small businesses and other for-profit organizations, state and local governments, special districts, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes a wide range of mission-driven and underrepresented-serving institutions and organizations, including faith-based and community-based organizations; Historically Black Colleges and Universities (HBCUs); Hispanic-serving institutions; Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, non-U.S. entities are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed. That structure supports multinational collaboration and inclusion of diverse populations, settings, and health systems where chronic wounds are a significant burden.
Key dates for this specific archived opportunity reflect its original competition cycle: it was posted and created on May 6, 2014, with an original and current closing date of July 24, 2014, and an archive date of August 24, 2014. Even though this particular FOA is archived, its description still provides a useful blueprint for the kinds of chronic wound research NIH has sought to stimulate: work that links mechanisms to meaningful clinical endpoints, identifies patients at highest risk, and produces actionable interventions that prevent wounds, speed healing, and reduce symptoms and downstream harms.
For applicants, the practical takeaway is that NIH was looking for well-designed R01 projects that connect chronic wound science to outcomes that matter for patients and caregivers. Successful projects under this type of announcement typically make a clear case for the clinical significance of the wound problem being targeted, define the biological and psychosocial factors under study, use rigorous methods to measure wound outcomes and adverse events, and demonstrate how the intervention or discovery could translate into improved care. The intended impact is a stronger evidence base for risk stratification and personalized or tailored treatment approaches, ultimately improving outcomes and quality of life for the large population living with or vulnerable to chronic wounds.
The full announcement and related details were hosted by NIH at: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-15-001.html, and the NIH Office of Extramural Research webmaster contact listed for access or linking issues was FBOWebmaster@OD.NIH.GOV.
FAQs: Chronic Wounds Advancing the Science from Prevention to Healing (R01)
What is this funding opportunity?
This is an NIH funding opportunity titled Chronic Wounds Advancing the Science from Prevention to Healing (R01). It is designed to advance research on chronic wounds, spanning prevention, understanding why wounds become chronic, and testing approaches to help wounds heal faster and with fewer complications.
What chronic wound types are emphasized?
The opportunity highlights common, costly chronic wounds, including diabetic foot ulcers, pressure injuries, and venous or arterial ulcers.
What is the overall goal of the program?
The overarching goal is to generate findings that help identify who is most at risk for chronic wounds and to support the development of more tailored, effective strategies to improve healing, reduce complications, and protect quality of life.
How does the FOA conceptualize chronic wounds?
The FOA frames chronic wounds as more than a local skin problem. It emphasizes that chronic wounds are shaped by complex biological processes and real-world psychosocial factors that influence risk, progression, symptoms, healing, and long-term outcomes.
What kinds of biological mechanisms does the FOA encourage applicants to study?
The announcement invites research to strengthen evidence on mechanisms behind chronic wound development, persistence, and repair. Examples listed include impaired perfusion, inflammation and immune dysregulation, infection and biofilms, neuropathy, metabolic dysfunction (including diabetes-related effects), tissue oxygenation, cellular senescence, and other physiologic barriers to healing.
Are psychosocial and behavioral factors within scope?
Yes. The FOA explicitly recognizes psychosocial and behavioral drivers that can influence outcomes, such as symptom burden (pain, itching, odor, exudate), adherence to offloading or compression, mobility limitations, self-care capacity, stress, depression, social support, and the broader care environment.
What kinds of research projects would fit this FOA?
Projects could range from studies that clarify risk pathways and markers for chronicity to research that explains why some patients do poorly despite receiving standard wound care. The FOA also supports intervention development and testing aimed at prevention, improved healing, and symptom reduction.
Is intervention research a major emphasis?
Yes. A major emphasis is intervention development and testing, including approaches to prevent chronic wounds before they start, accelerate healing once a wound exists, and reduce or manage wound-related symptoms that affect daily functioning and well-being.
What prevention topics are considered responsive?
The FOA supports prevention strategies for high-risk patients, including those with diabetes, limited mobility, vascular disease, or sensory loss.
What treatment or healing-focused topics are considered responsive?
The FOA supports work to accelerate healing once a wound exists, including approaches that address underlying biological barriers, optimize local wound conditions, and improve adherence to evidence-based care.
Does the FOA support symptom management research?
Yes. Reducing or managing wound-related symptoms is explicitly included, particularly symptoms that affect functioning and well-being (for example, pain, itching, odor, and exudate).
What kinds of interventions are allowed under this FOA?
The FOA frames intervention goals broadly. Innovations can be clinical, behavioral, educational, systems-level, or technology-enabled, as long as they are grounded in a strong rationale and designed to improve patient-centered outcomes.
What grant mechanism is used?
This FOA uses the NIH R01 mechanism, intended for substantial, hypothesis-driven research projects that can produce generalizable knowledge.
What is the funding opportunity number and CFDA listing?
The funding opportunity number is RFA-NR-15-001. It is listed under CFDA 93.361 (Nursing Research).
Does this FOA align with nursing science priorities?
Yes. The CFDA designation signals alignment with nursing research priorities such as symptom science, self-management, care delivery, and quality-of-life outcomes, while still allowing applicants from many disciplines.
How much total funding was estimated for this opportunity?
The total estimated funding described is $3,000,000.
What is the award ceiling?
The award ceiling stated is $350,000.
Is there a cost-sharing or matching requirement?
No. The FOA states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and governments, such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), small businesses and other for-profit organizations, state and local governments, special districts, independent school districts, and public housing authorities/Indian housing authorities.
Are community-based and faith-based organizations included?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicant types.
Are underrepresented-serving institutions explicitly included?
Yes. The FOA explicitly includes institutions such as HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Can non-U.S. organizations apply?
Yes. The FOA states that non-U.S. entities are eligible to apply. It also states that non-U.S. components of U.S. organizations are eligible and that foreign components (as defined by NIH policy) are allowed.
What does allowing foreign components mean in practical terms?
Based on the FOA language, the program structure supports multinational collaboration and inclusion of diverse populations, settings, and health systems where chronic wounds are a significant burden.
What were the key dates for this opportunity?
The FOA was posted/created on May 6, 2014. The original and current closing date listed is July 24, 2014. The archive date is August 24, 2014.
Is this FOA still active?
No. The information provided indicates this FOA is archived.
Why might an archived FOA still be useful?
Even though it is archived, the description provides a blueprint for the kinds of chronic wound research NIH sought to stimulate: work linking mechanisms to meaningful clinical endpoints, identifying patients at highest risk, and producing actionable interventions to prevent wounds, speed healing, and reduce symptoms and downstream harms.
What does NIH appear to have been looking for in strong applications?
Based on the description, competitive projects under this type of announcement typically: (1) make a clear case for the clinical significance of the wound problem being targeted; (2) define the biological and psychosocial factors under study; (3) use rigorous methods to measure wound outcomes and adverse events; and (4) show how the intervention or discovery could translate into improved care.
What outcomes and impacts are emphasized?
The intended impact is a stronger evidence base for risk stratification and personalized or tailored treatment approaches, ultimately improving outcomes and quality of life for people living with or vulnerable to chronic wounds.
Where was the full announcement hosted?
The FOA was hosted by NIH at: http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-15-001.html
Who was listed as the contact for access or linking issues?
The NIH Office of Extramural Research webmaster contact listed was FBOWebmaster@OD.NIH.GOV.
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