Opportunity Information: Apply for RFA HL 09 012
Apply for RFA HL 09 012
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Circadian Coupled Cellular Function in Heart, Lung, and Blood Tissue (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Oct 10, 2008 and posted on Oct 10, 2008.
- Applicants must submit their applications by Jan 6, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity "Circadian Coupled Cellular Function in Heart, Lung, and Blood Tissue (R01)" (Funding Opportunity Number RFA-HL-09-012) is a National Institutes of Health (NIH) grant announcement led by the National Heart, Lung, and Blood Institute (NHLBI). It is focused on advancing early-stage translation, specifically Phase I translation (often described as T1), of recent discoveries about circadian biology into a clearer understanding of disease mechanisms affecting heart, lung, and blood systems. In practical terms, the announcement is looking for research that connects modern molecular insights about the body s internal daily timing system to real questions about how cardiovascular, pulmonary, and hematologic diseases start, progress, or differ across time of day.
The scientific emphasis is on endogenous, self-sustaining circadian cycles that shape cellular function and gene expression. The intent is not simply to study circadian rhythms as an observational phenomenon, but to use contemporary molecular and cellular knowledge about circadian regulation to illuminate disease pathogenesis. Applications are expected to leverage advances in understanding how circadian clocks operate within cells and tissues, and then translate those insights toward mechanisms that matter for human health in heart, lung, and blood related conditions. The overall theme is "circadian coupled cellular function," meaning the institute is interested in how time-of-day biology is linked to, coordinated with, or drives cellular programs relevant to these tissues and disease states.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is the standard NIH vehicle for investigator-initiated research projects with defined aims and a multi-year plan. The announcement is categorized as discretionary funding and falls under the broader health activity area. No cost sharing or matching is required, which aligns with typical NIH research grant structures.
On funding scope, NHLBI indicated an expected total investment of about 12 million dollars spread across four years, contingent on the availability of funds and the submission of enough high-quality, competitive proposals. The anticipated number of awards is relatively small, estimated at roughly 4 to 6 grants, which signals a selective program aiming to fund a limited set of strong projects rather than a large portfolio of smaller studies. The listing also shows an estimated total funding figure of 3,000,000 dollars, which is consistent with the idea that the overall 12 million is distributed over multiple years while the estimate may reflect a single-year or annualized planning number in the database record.
Eligibility is broad and includes a wide range of public and private organizations. Eligible applicants include federal, state, local, and tribal government entities; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses and other for-profit entities); and various specialized governmental units such as special district governments, independent school districts, and public housing authorities. The announcement also explicitly includes categories frequently noted in NIH eligibility language, such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, it also allows non-U.S. entities (foreign organizations), expanding the applicant pool internationally where appropriate.
The opportunity is associated with several CFDA numbers tied to NHLBI and related NIH research areas, including cardiovascular, lung, and blood disease research, as well as human genome research and sleep disorders research, reflecting the cross-cutting nature of circadian science across genetics, sleep biology, and organ-specific disease mechanisms. The posting date and creation date are both October 10, 2008. The original and current closing date listed is January 6, 2009, and the archive date is February 6, 2009, indicating that this was a time-limited request for applications with a fixed submission window.
For applicants or institutions that have trouble accessing the full text of the announcement online, the contact route provided is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is also the point of contact for technical issues linking to the announcement. The full announcement was hosted through the NIH grants guide website at the provided link.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Circadian Coupled Cellular Function in Heart, Lung, and Blood Tissue (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-HL-09-012.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) grant announcement led by the National Heart, Lung, and Blood Institute (NHLBI).
What is the main purpose of this RFA?
The purpose is to advance early-stage translation (Phase I translation, often called T1) of recent circadian biology discoveries into a clearer understanding of disease mechanisms affecting heart, lung, and blood systems.
What does the program mean by "circadian coupled cellular function"?
The theme focuses on how endogenous, self-sustaining circadian cycles are linked to, coordinate with, or drive cellular programs relevant to heart, lung, and blood tissues and related disease states.
What kinds of scientific questions is NHLBI trying to support?
NHLBI is looking for research that uses modern molecular and cellular understanding of circadian clocks to illuminate disease pathogenesis in cardiovascular, pulmonary, and hematologic conditions, including how diseases start, progress, or differ across time of day.
Is the opportunity focused on observational studies of circadian rhythms?
No. The stated intent is not simply to study circadian rhythms as an observational phenomenon, but to use contemporary molecular and cellular knowledge about circadian regulation to understand mechanisms of disease.
Which tissues and disease areas are in scope?
The scientific scope centers on heart, lung, and blood tissues, with an emphasis on mechanisms relevant to cardiovascular, pulmonary, and hematologic diseases.
What grant mechanism is being used?
The opportunity uses the NIH Research Project Grant (R01) mechanism.
What does using an R01 mechanism imply about the type of project?
An R01 is NIH's standard mechanism for investigator-initiated research projects with defined aims and a multi-year research plan.
Is this discretionary funding?
Yes. The announcement is categorized as discretionary funding and falls under the broader health activity area.
Is cost sharing or matching required?
No. The opportunity states that no cost sharing or matching is required.
How much funding does NHLBI expect to invest overall?
NHLBI indicated an expected total investment of about $12 million spread across four years, contingent on the availability of funds and the submission of sufficient high-quality, competitive applications.
How many awards are anticipated?
The anticipated number of awards is relatively small, estimated at roughly 4 to 6 grants.
Why does the listing also show an estimated total funding figure of $3,000,000?
The information provided notes that this is consistent with the idea that the overall $12 million is distributed over multiple years, while the $3,000,000 figure may reflect a single-year or annualized planning number in the database record.
Who is eligible to apply?
Eligibility is broad and includes public and private organizations. Eligible applicants include federal, state, local, and tribal government entities; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; and for-profit organizations (including small businesses and other for-profit entities).
Are specialized government entities eligible (for example, school districts or housing authorities)?
Yes. The eligible applicant types listed include specialized governmental units such as special district governments, independent school districts, and public housing authorities.
Are minority-serving institutions specifically included in the eligibility language?
Yes. The announcement explicitly includes categories often highlighted in NIH eligibility language, including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian serving institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included in the listed eligible applicant categories.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly included among eligible applicants.
Are foreign (non-U.S.) organizations allowed to apply?
Yes. The opportunity allows non-U.S. entities (foreign organizations), expanding the applicant pool internationally where appropriate.
What CFDA program areas are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers tied to NHLBI and related NIH research areas, including cardiovascular, lung, and blood disease research, as well as human genome research and sleep disorders research.
When was this opportunity posted?
The posting date and creation date are both October 10, 2008.
What was the application due date (closing date)?
The original and current closing date listed is January 6, 2009.
When was the opportunity archived?
The archive date is February 6, 2009.
Is this a time-limited funding opportunity?
Yes. The dates provided indicate it was a time-limited request for applications with a fixed submission window.
Where was the full announcement hosted?
The full announcement was hosted through the NIH grants guide website at the provided link referenced in the opportunity information.
Who should be contacted for technical issues accessing the announcement text online?
For institutions or applicants who have trouble accessing the full text online, the contact route provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Is the contact listed meant for scientific questions about the program?
The information provided describes this contact as a point of contact for technical issues linking to the announcement and for trouble accessing the full text online.
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