Opportunity Information: Apply for RFA TR 14 009
Apply for RFA TR 14 009
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical and Translational Science Award (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350 National Center for Advancing Translational Sciences.
- This funding opportunity was created on Sep 18, 2014 and posted on Sep 12, 2014.
- Applicants must submit their applications by Jan 15, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $110,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $10,000,000.00 in funding.
- The number of recipients for this funding is limited to 21 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) The CTSA application may include domestic institutions of higher education, universities, academic health centers, or non profit research organizations other than institutions of higher education that conduct clinical and translational research however, a graduate school accredited to award higher degrees in clinical or translational science must be included (e.g., M.S. or Ph.D. in topics such as Clinical Research, Public Health, Pharmacology, Nursing, Informatics, Health Economics, or Epidemiology. Partnerships are encouraged among various disciplines including medicine, dentistry, nursing, pharmacy, osteopathy, public health, engineering and others). Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Clinical and Translational Science Award (CTSA) (U54) opportunity, issued by the National Institutes of Health through the National Center for Advancing Translational Sciences (NCATS), is a cooperative agreement designed to strengthen and expand the national infrastructure for clinical and translational research. The core goal is to support high-quality translational and clinical research at the local, regional, and national levels while also driving innovation in the methods, tools, training models, and career development approaches that make translational science more efficient and impactful. In practice, this FOA is meant to help institutions build or enhance coordinated programs that move discoveries along the pipeline from basic science toward clinical applications and improvements in patient and population health, while also improving how that pipeline functions.
This funding opportunity is identified as RFA-TR-14-009 and falls under the health activity category, using the cooperative agreement mechanism (U54). A cooperative agreement indicates that NIH expects to have substantial involvement in the project beyond standard grant oversight, typically through collaborative programmatic input, coordination expectations, and alignment with broader CTSA program goals. The FOA projected a large national investment, with an estimated total funding amount of about $110,000,000 and an anticipated 21 awards. The award ceiling listed is $10,000,000, and there is no cost sharing or matching requirement, which can reduce barriers for applicants proposing ambitious infrastructure and programmatic elements.
Eligible applicants include a wide range of U.S.-based organizations, particularly institutions that can demonstrate the capacity to conduct clinical and translational research and to support robust education and workforce development in related fields. Eligible entities include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both with and without 501(c)(3) status) that are not institutions of higher education. The FOA also explicitly recognizes and includes several categories of institutions that serve historically underrepresented communities, such as Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). This emphasis aligns with broader translational science priorities, including expanding participation, strengthening workforce diversity, and ensuring that research benefits are broadly distributed.
A key eligibility condition is that the CTSA application must include a graduate school accredited to award higher degrees in clinical or translational science, such as an M.S. or Ph.D., in areas that support translational research. Examples listed include Clinical Research, Public Health, Pharmacology, Nursing, Informatics, Health Economics, and Epidemiology. This requirement reflects the program's strong focus on training and career development, ensuring that funded hubs are not only conducting research but also producing the next generation of translational scientists and research professionals. The FOA encourages partnerships across disciplines and professions, highlighting medicine, dentistry, nursing, pharmacy, osteopathy, public health, engineering, and other related areas, which underscores the expectation that applicants will build integrated, cross-cutting programs rather than isolated departmental efforts.
In terms of geographic eligibility, non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components, as defined under the NIH Grants Policy Statement, are allowed. This typically means a primarily U.S.-led application can include certain international elements if they are justified, compliant with NIH policy, and relevant to the project, while the applicant organization and primary program infrastructure remain domestic.
From an applicant's standpoint, the CTSA (U54) announcement is essentially a call to create or strengthen a comprehensive translational science “hub” that can support multiple functions at once: enabling high-quality clinical and translational research, improving the processes and methodologies that make translational science faster and more reliable, and building structured training and career development pathways. The program’s scope implies institution-wide coordination and a commitment to serve broader communities of investigators, trainees, and partners. Because it is designed to foster innovation in methods and training, a competitive application would typically be expected to propose not only solid research support capacity but also forward-looking approaches that improve how studies are designed, conducted, analyzed, and translated into real-world impact.
Key dates for this archived opportunity include a posted date of September 12, 2014, an original closing date of December 16, 2014, and a current closing date of January 15, 2015, with an archive date of February 14, 2015. The CFDA number associated with the program is 93.350, and further details were provided through the NIH grants guide link included in the announcement. For access issues or technical problems with the listing, the contact point referenced is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the Clinical and Translational Science Award (CTSA) (U54) opportunity?
The CTSA (U54) is a National Institutes of Health (NIH) cooperative agreement opportunity issued through the National Center for Advancing Translational Sciences (NCATS). It is designed to strengthen and expand the national infrastructure for clinical and translational research by supporting coordinated programs that move discoveries from basic science toward clinical applications and improvements in patient and population health.
What is the main goal of this funding opportunity?
The core goal is to support high-quality translational and clinical research at local, regional, and national levels, while also driving innovation in methods, tools, training models, and career development approaches that make translational science more efficient and impactful.
What is the funding opportunity announcement (FOA) number?
The FOA is identified as RFA-TR-14-009.
Which NIH institute/center is sponsoring this FOA?
This FOA is issued by NIH through the National Center for Advancing Translational Sciences (NCATS).
What type of award mechanism is used?
The award uses the cooperative agreement mechanism, U54.
What does it mean that this is a cooperative agreement (U54)?
A cooperative agreement indicates that NIH expects substantial involvement in the project beyond standard grant oversight. This typically includes collaborative programmatic input, coordination expectations, and alignment with broader CTSA program goals.
What is the estimated total funding amount for this FOA?
The FOA projected an estimated total funding amount of about $110,000,000.
How many awards were anticipated?
The FOA anticipated approximately 21 awards.
What is the award ceiling?
The listed award ceiling is $10,000,000.
Is cost sharing or matching required?
No. The FOA indicates there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligible applicants include U.S.-based organizations such as public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (with or without 501(c)(3) status) that are not institutions of higher education.
Are institutions serving historically underrepresented communities explicitly included?
Yes. The FOA explicitly recognizes several categories of institutions, including Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Is there a specific training-related eligibility requirement?
Yes. A key condition is that the CTSA application must include a graduate school accredited to award higher degrees in clinical or translational science (such as an M.S. or Ph.D.) in areas that support translational research.
What degree areas are examples of acceptable clinical or translational science fields?
Examples listed include Clinical Research, Public Health, Pharmacology, Nursing, Informatics, Health Economics, and Epidemiology.
Does the FOA encourage cross-disciplinary partnerships?
Yes. The FOA encourages partnerships across disciplines and professions, including medicine, dentistry, nursing, pharmacy, osteopathy, public health, engineering, and other related areas, reflecting an expectation for integrated, cross-cutting programs.
Are non-U.S. (foreign) institutions eligible to apply?
No. Non-U.S. (foreign) institutions are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible to apply.
Are any international elements allowed at all?
Yes. Foreign components, as defined under the NIH Grants Policy Statement, are allowed. This generally means a primarily U.S.-led application may include certain international elements if they are justified, compliant with NIH policy, and relevant to the project, while the applicant organization and primary program infrastructure remain domestic.
What kinds of activities is this FOA meant to support?
This FOA is meant to help institutions create or strengthen a comprehensive translational science "hub" that supports multiple functions at once, including enabling high-quality clinical and translational research, improving processes and methodologies that make translational science faster and more reliable, and building structured training and career development pathways.
What does "hub" mean in the context of this CTSA opportunity?
Based on the FOA description, a hub refers to an institution-wide, coordinated program that supports a broader community of investigators, trainees, and partners and helps move discoveries along the pipeline from basic science to clinical applications and health impact, while improving how that pipeline functions.
What is the activity category for this opportunity?
The opportunity falls under the health activity category.
What are the key dates listed for this (archived) opportunity?
Key dates include a posted date of September 12, 2014; an original closing date of December 16, 2014; a current closing date of January 15, 2015; and an archive date of February 14, 2015.
Is this opportunity archived?
Yes. An archive date of February 14, 2015 is provided, indicating the listing is archived.
What is the CFDA number associated with this program?
The CFDA number associated with the program is 93.350.
Where were additional details provided?
Further details were provided through the NIH grants guide link included in the announcement.
Who should be contacted for access issues or technical problems with the listing?
The contact referenced for access issues or technical problems is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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