Opportunity Information: Apply for PAR 15 304

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical and Translational Science Award (U54)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350 National Center for Advancing Translational Sciences.
  • This funding opportunity was created on Jul 23, 2015 and posted on Jul 23, 2015.
  • Applicants must submit their applications by May 25, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Clinical and Translational Science Award (CTSA) program (U54) is a National Institutes of Health funding opportunity designed to build and strengthen institutional “hubs” that can accelerate the movement of scientific discoveries into real-world improvements in health. The program focuses on supporting high-quality clinical and translational research at the local, regional, and national levels, while also encouraging innovation in the way translational research is conducted. In practice, this means awardees are expected to create or enhance the infrastructure, expertise, and collaborative environment needed to make research more efficient, more rigorous, and more likely to translate into patient and community benefit.

This opportunity is offered as a cooperative agreement (U54), which generally signals substantial involvement by the NIH in the funded project compared with a standard grant mechanism. The administering NIH component is the National Center for Advancing Translational Sciences (NCATS), and the activity falls under the Health category (CFDA 93.350). The FOA emphasizes not only research capacity, but also the development of better research methods and systems, including innovative approaches to study design, implementation, recruitment, data management, and other operational elements that affect the speed and quality of translational science. Alongside research support, the CTSA program places strong attention on training and career development, aiming to cultivate a skilled translational workforce and strengthen the pipeline of investigators who can bridge basic science, clinical investigation, and community or population health impact.

Eligibility is broad across U.S.-based organizations that can serve as strong translational research hubs. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and certain nonprofit organizations (including both 501(c)(3) nonprofits and nonprofits without 501(c)(3) status, as specified). The FOA also explicitly recognizes several categories of institutions as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations are not eligible to apply; however, “foreign components” may be allowed as defined under the NIH Grants Policy Statement, which typically means a discrete element of the overall project that is performed outside the U.S. under specific justification and oversight.

There is no cost sharing or matching requirement stated for this opportunity, which reduces the need for applicants to provide non-federal funds as a condition of the award. The opportunity was posted on July 23, 2015, and the final application due date listed is May 25, 2018, with an archive date of June 25, 2018, meaning it is no longer open for new submissions under that specific announcement. For applicants or stakeholders seeking the official archived announcement and full requirements, the FOA is identified as PAR-15-304 and is available through NIH’s grants policy and funding announcement system. For technical access issues, the NIH Office of Extramural Research (OER) webmaster contact is provided in the source information.

Clinical and Translational Science Award (CTSA) Program (U54) FAQs

1) What is the Clinical and Translational Science Award (CTSA) program (U54)?

The CTSA program (U54) is a National Institutes of Health (NIH) funding opportunity designed to build and strengthen institutional "hubs" that accelerate the movement of scientific discoveries into real-world improvements in health. It supports clinical and translational research capacity and encourages innovation in how translational research is carried out.

2) What is the main purpose of the CTSA "hub" model?

The hub model is intended to create or enhance the infrastructure, expertise, and collaborative environment needed to make translational research more efficient, more rigorous, and more likely to produce patient and community benefit.

3) Which NIH organization administers this opportunity?

This opportunity is administered by the National Center for Advancing Translational Sciences (NCATS), an NIH component focused on advancing translational science.

4) What type of funding mechanism is the CTSA U54 award?

The CTSA is offered as a cooperative agreement (U54). This generally indicates substantial NIH involvement in the funded project compared with a standard grant mechanism.

5) What does "cooperative agreement" (U54) mean for applicants and awardees?

Because it is a cooperative agreement, the NIH is typically expected to have a more active role in the project than under traditional grant mechanisms. The opportunity description notes that U54 "generally signals substantial involvement by the NIH" in the funded project.

6) What kinds of activities does the FOA emphasize supporting?

The FOA emphasizes supporting high-quality clinical and translational research at local, regional, and national levels, while also encouraging innovation in translational research operations and systems.

7) Does the CTSA program support innovation in research methods and operations?

Yes. The FOA highlights improving research methods and systems, including innovative approaches to study design, implementation, recruitment, data management, and other operational elements that affect the speed and quality of translational science.

8) Beyond research capacity, what else is a priority for the CTSA program?

In addition to research support and capacity-building, the CTSA program places strong attention on training and career development to cultivate a skilled translational workforce and strengthen the pipeline of investigators.

9) Who is eligible to apply?

Eligibility is broad across U.S.-based organizations that can serve as strong translational research hubs. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and certain nonprofit organizations (including 501(c)(3) nonprofits and specified nonprofits without 501(c)(3) status).

10) Are minority-serving institutions explicitly included as eligible applicants?

Yes. The FOA explicitly recognizes eligibility for multiple categories of institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

11) Are non-U.S. (foreign) institutions eligible to apply directly?

No. Non-U.S. (foreign) institutions are not eligible to apply under this opportunity.

12) Are non-U.S. components of U.S. organizations eligible to apply?

No. Non-U.S. components of U.S. organizations are not eligible to apply under this opportunity.

13) Are "foreign components" allowed at all under this opportunity?

Potentially, yes. While foreign institutions and non-U.S. components are not eligible to apply, "foreign components" may be allowed as defined under the NIH Grants Policy Statement. In general terms, this refers to a discrete element of the overall project performed outside the U.S. with appropriate justification and oversight.

14) Is cost sharing or matching required?

No cost sharing or matching requirement is stated for this opportunity.

15) What is the CFDA number and category for this opportunity?

The opportunity is listed under the Health category with CFDA 93.350.

16) When was this funding opportunity posted?

The opportunity was posted on July 23, 2015.

17) What was the final application due date?

The final application due date listed is May 25, 2018.

18) Is this FOA still open for new applications?

No. The archive date is June 25, 2018, and the described announcement is no longer open for new submissions under that specific FOA.

19) What is the FOA identifier for the archived announcement?

The FOA is identified as PAR-15-304.

20) Where can applicants find the official archived announcement and full requirements?

The official archived announcement and full requirements are available through NIH's grants policy and funding announcement system under FOA number PAR-15-304.

21) Who should be contacted for technical access issues related to the FOA?

For technical access issues, the source information references the NIH Office of Extramural Research (OER) webmaster contact.

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