Opportunity Information: Apply for RFA DK 16 010
Apply for RFA DK 16 010
- The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "Clinical Centers to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847,.
- This funding opportunity was created on Dec 22, 2015 and posted on Dec 22, 2015.
- Applicants must submit their applications by Mar 02, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity titled "Clinical Centers to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium (U01)" (RFA-DK-16-010) is a National Institutes of Health program from HHS/NIH (specifically NIDDK, listed under HHS-NIH11) designed to support a clinical research center that will participate in the NIDDK Gastroparesis Consortium. The overall purpose is to strengthen and coordinate clinical and translational research on gastroparesis (GP), with an emphasis on understanding why the disease develops and persists, how it presents in different patients, how it affects daily functioning and quality of life, and how to move toward better treatments. Because it uses a U01 cooperative agreement mechanism, the work is expected to be carried out in close collaboration with NIH program staff and within the structure and priorities of the broader consortium, rather than operating as a fully investigator-initiated standalone grant.
In practical terms, the FOA calls for a Clinical Center (CC) capable of conducting human-subjects research focused on gastroparesis, including studies that can connect clinical findings to underlying biology. The research scope is broad but targeted: applicants are expected to investigate cellular and molecular mechanisms implicated in GP, explore disease expression (how symptoms, severity, and clinical patterns vary across individuals and subgroups), address patient-centered outcomes such as quality of life, and support the development and testing of new therapeutic interventions. The emphasis on pathogenesis and etiology signals interest in identifying root causes and mechanistic drivers, not only describing symptoms. At the same time, the explicit reference to treatment development indicates that the consortium intends to translate mechanistic insights into practical interventions, potentially including novel therapeutics, improved clinical strategies, or other approaches that can be evaluated in a rigorous clinical research framework.
The opportunity is categorized under discretionary funding and falls within the health and food/nutrition-related NIH activity area, with CFDA numbers 93.847 listed. Eligibility is broad and includes multiple types of domestic organizations that can operate a clinical research program: state, county, and local governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses and other for-profit entities); and eligible Native American tribal governments and tribal organizations, as well as public housing authorities/Indian housing authorities. This wide eligibility reflects NIH's intent to attract strong clinical research infrastructures regardless of organizational type, as long as the applicant can meet the scientific, operational, and compliance requirements typical for NIH-supported clinical studies.
From an administrative standpoint, the FOA was posted on December 22, 2015, and had a closing date of March 2, 2016. The listed award ceiling is $250,000, and the expected number of awards is 1, indicating a highly competitive solicitation aimed at selecting a single Clinical Center award under this specific announcement. In summary, the opportunity is meant to stand up or support a key clinical site within the NIDDK Gastroparesis Consortium to conduct coordinated, mechanism-informed clinical research on gastroparesis, while also addressing real-world patient impact and accelerating progress toward better therapies.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Clinical Centers to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium (U01)" and is identified as RFA-DK-16-010.
Which agency is offering this opportunity?
This is a National Institutes of Health (NIH) opportunity under the U.S. Department of Health and Human Services (HHS), specifically through NIDDK (listed under HHS-NIH11).
What is the main purpose of the opportunity?
The purpose is to support a Clinical Center that will participate in the NIDDK Gastroparesis Consortium, strengthening and coordinating clinical and translational research on gastroparesis. The focus includes understanding why gastroparesis develops and persists, how it presents across different patients, how it impacts daily functioning and quality of life, and how to move toward improved treatments.
What kind of award mechanism is this (and why does it matter)?
This opportunity uses a U01 cooperative agreement mechanism. That means the funded work is expected to be carried out in close collaboration with NIH program staff and aligned with the structure and priorities of the broader consortium, rather than operating as a fully investigator-initiated standalone grant.
What is being funded: a project, a network, or a site?
The FOA calls for a Clinical Center (CC) capable of conducting human-subjects research focused on gastroparesis and contributing to the NIDDK Gastroparesis Consortium.
What research areas are emphasized in this FOA?
The scope is broad but targeted. Applicants are expected to address (1) pathogenesis and etiology (root causes and mechanistic drivers), (2) disease expression (how symptoms, severity, and clinical patterns vary across individuals and subgroups), (3) patient-centered outcomes such as daily functioning and quality of life, and (4) development and testing of new therapeutic interventions.
Does this opportunity support human-subjects research?
Yes. The Clinical Center is expected to be capable of conducting human-subjects research focused on gastroparesis, including studies that can connect clinical findings to underlying biology.
Is the focus only on describing symptoms, or also on underlying biology?
The FOA emphasizes understanding pathogenesis and etiology, signaling interest in identifying root causes and mechanistic drivers, not only describing symptoms.
Is treatment development part of the expected work?
Yes. The FOA explicitly references treatment development and indicates an intent to translate mechanistic insights into practical interventions that can be evaluated within a rigorous clinical research framework.
What types of interventions or treatments are implied?
The FOA describes moving toward better treatments and mentions the potential for novel therapeutics, improved clinical strategies, or other approaches that can be tested in coordinated clinical research. Specific intervention types are not detailed in the provided information.
How does the consortium structure affect what the Clinical Center can do?
Because the award is a U01 cooperative agreement within the NIDDK Gastroparesis Consortium, the Clinical Center is expected to work within consortium priorities and collaborate closely with NIH program staff rather than operating independently.
How is this opportunity categorized (funding type and activity area)?
The opportunity is categorized under discretionary funding and falls within a health and food/nutrition-related NIH activity area. The CFDA number listed is 93.847.
Who is eligible to apply?
Eligibility is broad and includes domestic organizations such as state, county, and local governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses and other for-profit entities); eligible Native American tribal governments and tribal organizations; and public housing authorities/Indian housing authorities.
Are for-profit organizations allowed to apply?
Yes. For-profit organizations, including small businesses and other for-profit entities, are included in the eligibility list.
Are tribal governments and tribal organizations eligible?
Yes. Eligible Native American tribal governments and tribal organizations are included in the eligibility list.
Are government entities (state, county, local) eligible?
Yes. State, county, and local governments are listed as eligible applicants.
Are universities and colleges eligible?
Yes. Public and private institutions of higher education are listed as eligible applicants.
Are nonprofits required to have 501(c)(3) status?
No. The eligibility list includes nonprofit organizations with or without 501(c)(3) status.
Does the FOA specify whether applicants must be domestic?
The eligibility description provided specifies multiple types of domestic organizations that can operate a clinical research program.
What is the award ceiling?
The listed award ceiling is $250,000.
How many awards are expected?
The expected number of awards is 1, indicating a single Clinical Center award under this announcement.
When was the FOA posted, and what was the closing date?
The FOA was posted on December 22, 2015, and had a closing date of March 2, 2016.
How competitive is this opportunity likely to be?
Based on the information provided, it is likely to be highly competitive because only one award is expected under this solicitation.
What does a "Clinical Center (CC)" need to be capable of doing?
The FOA calls for a Clinical Center capable of conducting human-subjects gastroparesis research, including clinical and translational studies that connect clinical findings to underlying cellular and molecular mechanisms, while also supporting patient-centered outcomes research and therapeutic development/testing within a consortium framework.
What is the overall goal in plain terms?
The goal is to establish or support a key clinical site within the NIDDK Gastroparesis Consortium to run coordinated, mechanism-informed clinical research on gastroparesis, address real-world patient impact (including quality of life), and accelerate progress toward better therapies.
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| Silvio O. Conte Digestive Diseases Research Core Centers (P30) Apply for RFA DK 16 019 Funding Number: RFA DK 16 019 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $750,000 |
| NIDDK Program Projects (P01) Apply for PAR 16 127 Funding Number: PAR 16 127 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $6,250,000 |
| High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2) Apply for PAR 16 126 Funding Number: PAR 16 126 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Early-Stage Preclinical Validation of Therapeutic Leads for Diseases of Interest to the NIDDK (R01) Apply for PAR 16 121 Funding Number: PAR 16 121 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 16 148 Funding Number: PAR 16 148 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $50,000 |
| Advances in Polycystic Kidney Disease (R01) Apply for PA 16 159 Funding Number: PA 16 159 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Human Islet Distribution Coordinating Center (UC4) Apply for RFA DK 16 023 Funding Number: RFA DK 16 023 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $1,300,000 |
| Limited Competition: Rare Diseases Clinical Research Network (RDCRN) Project Supplements for Clinical Trials to Repurpose Drugs in Collaboration with E-Rare Awardees (Admin Supp) Apply for PA 16 183 Funding Number: PA 16 183 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Short-Term Research Experience Program for Underrepresented Persons (STEP-UP) (R25) Apply for RFA DK 16 021 Funding Number: RFA DK 16 021 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Mentored Research Scientist Development Award (K01) Apply for PAR 16 211 Funding Number: PAR 16 211 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Nutrition Obesity Research Centers (NORCs) (P30) Apply for RFA DK 16 006 Funding Number: RFA DK 16 006 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Standardization of C-peptide and HbA1c Measurements Program (UC4) Apply for RFA DK 16 011 Funding Number: RFA DK 16 011 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Diabetes Research Centers (P30) Apply for RFA DK 16 020 Funding Number: RFA DK 16 020 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01) Apply for PAR 16 304 Funding Number: PAR 16 304 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Collaborative Islet Transplantation Registry (UC4) Apply for RFA DK 16 503 Funding Number: RFA DK 16 503 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Neurocognitive Effects of Glycemic Dysregulation in Type 1 Diabetes (DP3) Apply for RFA DK 16 007 Funding Number: RFA DK 16 007 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: $3,000,000 |
| Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01) Apply for PAR 16 333 Funding Number: PAR 16 333 Agency: HHS-NIH11 Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pediatric Centers of Excellence in Nephrology (P50) Apply for RFA DK 16 032 Funding Number: RFA DK 16 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| George M. O'Brien Kidney Research Core Centers (P30) Apply for RFA DK 16 031 Funding Number: RFA DK 16 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 16 022 Funding Number: RFA DK 16 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
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