Opportunity Information: Apply for RFA HL 14 023
Apply for RFA HL 14 023
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical Research in the Prevention, Diagnosis, and Treatment of HIV Related Heart, Lung, and Blood (HLB) Diseases in Adults and Children (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jan 7, 2015 and posted on Oct 24, 2013.
- Applicants must submit their applications by Jan 8, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $499,999.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-HL-14-023, titled "Clinical Research in the Prevention, Diagnosis, and Treatment of HIV Related Heart, Lung, and Blood (HLB) Diseases in Adults and Children (R01)," supports clinical research projects focused specifically on how HIV intersects with diseases of the heart, lungs, and blood in both adult and pediatric populations. The central purpose is to close key scientific and clinical gaps in understanding these HIV-associated HLB conditions and to move the field toward better ways to characterize risk, prevent disease, improve diagnostic approaches, and evaluate treatments. A major emphasis is on generating clinically meaningful evidence that can inform real-world care for people living with HIV who face elevated or unique risks of cardiovascular, pulmonary, and hematologic complications.
This FOA is designed for R01 clinical research projects and is intentionally broad in the types of study designs it will consider appropriate. Applicants may propose observational studies, quasi-experimental approaches, and single-center studies, including pilot clinical trials. While the announcement is not limited to one methodology, it clearly encourages practical, feasible clinical research that can produce actionable insights, particularly where knowledge is limited or where existing findings need validation in HIV-affected populations. Another key feature is the preference for leveraging existing research assets whenever possible, such as established clinical cohorts, biorepositories of biological specimens, and imaging banks. In other words, projects that build efficiently on existing infrastructure, data, and samples are strongly encouraged, both to accelerate progress and to maximize the value of prior investments.
The program also highlights the importance of multidisciplinary collaboration. HIV-related HLB diseases sit at the intersection of infectious disease, cardiology, pulmonology, hematology, pediatrics, epidemiology, imaging, and implementation-focused clinical research. The FOA signals that proposals bringing together complementary expertise across these domains are especially aligned with its intent, since addressing HIV-associated HLB complications often requires integrated thinking about virology, immune activation and inflammation, antiretroviral therapy exposures, comorbidities, social and behavioral determinants, and healthcare delivery factors.
From an administrative standpoint, this is a discretionary NIH grant opportunity in the health category, using the R01 (research project grant) funding mechanism. It was posted on October 24, 2013, with an original closing date of January 8, 2015, a subsequent closing date listed as January 8, 2016, and an archive date of February 8, 2016. The listed award ceiling is $499,999, and the opportunity does not require cost sharing or matching funds. The FOA is associated with multiple CFDA numbers that map to relevant NIH research areas, including sleep disorders research (93.233) and research programs in cardiovascular diseases (93.837), lung diseases (93.838), and blood diseases and resources (93.839), reflecting the broad heart-lung-blood scope within HIV-related clinical complications.
Eligibility is expansive across U.S.-based organizational types and includes public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses as a distinct category, though small businesses are also listed as eligible), state and local governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The eligibility language also explicitly includes a wide range of mission-driven and capacity-building institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions, as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Non-U.S. (foreign) institutions are not eligible to apply as the applicant organization; however, non-U.S. components of U.S. organizations are allowed, and foreign components (as defined under NIH policy) may be included, which provides a pathway for incorporating international expertise or data sources when they are part of a U.S.-led application.
Overall, the FOA is aimed at strengthening the evidence base for HIV-associated heart, lung, and blood disease across the life course, with an emphasis on clinically grounded research and efficient use of existing cohorts and specimen/imaging resources. The complete announcement was hosted by NIH, with an additional information link provided through the NIH grants guide, and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the opportunity.
FAQs: NIH RFA-HL-14-023 (R01) - HIV-Related Heart, Lung, and Blood (HLB) Diseases
What is the funding opportunity called?
The opportunity is NIH RFA-HL-14-023, titled "Clinical Research in the Prevention, Diagnosis, and Treatment of HIV Related Heart, Lung, and Blood (HLB) Diseases in Adults and Children (R01)."
What is the main purpose of this FOA?
The purpose is to support clinical research that closes key scientific and clinical gaps in understanding HIV-associated heart, lung, and blood diseases, and to move the field toward better risk characterization, prevention, diagnosis, and treatment approaches for people living with HIV.
What populations are the focus of this program?
The FOA supports research in both adult and pediatric populations, with a focus on people living with HIV who may face elevated or unique risks of cardiovascular, pulmonary, and hematologic complications.
What disease areas are included under "HLB" in this FOA?
What kinds of research questions is the FOA trying to address?
It emphasizes clinically meaningful evidence to inform real-world care, including improving how risk is characterized, how disease is prevented, how diagnoses are made, and how treatments are evaluated in HIV-affected populations.
What funding mechanism does this announcement use?
This is an NIH R01 (research project grant) opportunity intended for clinical research projects.
Is this FOA limited to a single type of study design?
No. The FOA is intentionally broad and will consider multiple study designs. It specifically mentions observational studies, quasi-experimental approaches, single-center studies, and pilot clinical trials as examples of designs that may be proposed.
Does the FOA support pilot clinical trials?
Yes. Pilot clinical trials are explicitly listed among the types of studies that may be proposed (including as single-center studies).
Is the FOA focused on feasibility and real-world applicability?
Yes. It encourages practical, feasible clinical research that can produce actionable insights, particularly in areas where knowledge is limited or where existing findings need validation specifically in HIV-affected populations.
Does the FOA encourage the use of existing cohorts and resources?
Yes. A stated preference is to leverage existing research assets whenever possible, including established clinical cohorts, biorepositories of biological specimens, and imaging banks.
Why does the FOA encourage leveraging existing infrastructure?
Projects that build on existing infrastructure, data, and samples are encouraged to accelerate progress and maximize the value of prior investments.
Is multidisciplinary collaboration important for this program?
Yes. The FOA highlights the importance of multidisciplinary collaboration because HIV-related HLB diseases sit at the intersection of multiple fields.
What disciplines are described as relevant to this FOA?
The FOA references infectious disease, cardiology, pulmonology, hematology, pediatrics, epidemiology, imaging, and implementation-focused clinical research as relevant areas of expertise.
What factors does the FOA suggest researchers may need to consider when studying HIV-associated HLB complications?
It points to the need for integrated thinking about virology, immune activation and inflammation, antiretroviral therapy exposures, comorbidities, social and behavioral determinants, and healthcare delivery factors.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $499,999.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching funds.
When was this funding opportunity posted?
It was posted on October 24, 2013.
What are the closing dates shown for this FOA?
The information provided lists an original closing date of January 8, 2015, and a subsequent closing date of January 8, 2016.
When was the FOA archived?
The archive date listed is February 8, 2016.
What general category is this opportunity in?
It is described as a discretionary NIH grant opportunity in the health category.
Which CFDA numbers are associated with this FOA?
The FOA is associated with multiple CFDA numbers, including sleep disorders research (93.233) and NIH research programs in cardiovascular diseases (93.837), lung diseases (93.838), and blood diseases and resources (93.839).
Who is eligible to apply?
Eligibility is expansive across U.S.-based organizational types, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (and small businesses are also listed), state and local governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, tribal governments, and tribal organizations.
Are mission-driven and capacity-building institutions included in the eligibility language?
Yes. The eligibility language explicitly includes HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions, among others.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included among eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly listed as eligible.
Are eligible federal agencies included?
Yes. Eligible federal agencies are listed among the eligible applicants.
Can a non-U.S. (foreign) institution apply as the applicant organization?
No. Non-U.S. (foreign) institutions are not eligible to apply as the applicant organization under this FOA.
Can a U.S. applicant include foreign or international components in the project?
Yes. The information provided states that non-U.S. components of U.S. organizations are allowed, and foreign components (as defined under NIH policy) may be included, enabling international expertise or data sources within a U.S.-led application.
Where was the complete announcement hosted, and where could additional information be found?
The complete announcement was hosted by NIH, and an additional information link was provided through the NIH grants guide.
Who was listed as a contact for technical access issues?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the opportunity.
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